SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		4 / 6 LEU A 227
VAL A 264
VAL A 252
ILE A 243
 None
 1.11A 2hyyB-5w15A:
undetectable		 2hyyB-5w15A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8F_A_DM1A127_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 10 ALA A  95
VAL A 120
ALA A 263
VAL A  52
TRP A  39
 None
 0.99A 3f8fA-5w15A:
undetectable
3f8fB-5w15A:
0.2		 3f8fA-5w15A:
16.98
3f8fB-5w15A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 11 GLY A  61
PHE A  34
ASP A  56
ALA A  16
ARG A   7
 None
 1.04A 3g88A-5w15A:
2.0		 3g88A-5w15A:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 11 GLY A  61
PHE A  34
ASP A  56
ALA A  16
ARG A   7
 None
 1.03A 3g88B-5w15A:
undetectable		 3g88B-5w15A:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		6 / 12 GLY A  61
PHE A  34
ASP A  56
ALA A  16
ARG A   7
ALA A 177
 None
 1.28A 3g89A-5w15A:
undetectable		 3g89A-5w15A:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		6 / 11 GLY A  61
PHE A  34
ASP A  56
ALA A  16
ARG A   7
ALA A 177
 None
 1.27A 3g89B-5w15A:
undetectable		 3g89B-5w15A:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 12 GLY A  61
PHE A  34
ASP A  56
ALA A  16
ARG A   7
 None
 1.09A 3g8bA-5w15A:
undetectable		 3g8bA-5w15A:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		6 / 12 GLY A  61
PHE A  34
ASP A  56
ALA A  16
ARG A   7
ALA A 177
 None
 1.31A 3g8bB-5w15A:
undetectable		 3g8bB-5w15A:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		4 / 8 TYR A  55
VAL A  29
GLN A 191
GLY A  99
 None
 0.74A 3hjoA-5w15A:
undetectable		 3hjoA-5w15A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		4 / 6 LEU A 227
VAL A 264
VAL A 252
ILE A 243
 None
 1.12A 3k5vA-5w15A:
undetectable		 3k5vA-5w15A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		4 / 6 LEU A 227
VAL A 264
VAL A 252
ILE A 243
 None
 1.05A 3k5vB-5w15A:
undetectable		 3k5vB-5w15A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 10 VAL A 163
TYR A 175
GLY A 249
GLY A 219
TRP A 218
 None
 1.29A 3ls4H-5w15A:
undetectable		 3ls4H-5w15A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		4 / 8 TRP A 179
VAL A 155
HIS A 151
PHE A 132
 None
 1.23A 3v35A-5w15A:
undetectable		 3v35A-5w15A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 12 LEU A  94
ALA A  95
LEU A  83
HIS A 107
LEU A 104
 None
 1.23A 4j24D-5w15A:
undetectable		 4j24D-5w15A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 12 GLU A 201
ALA A 124
ASP A 202
ALA A 203
TYR A 207
 None
 1.21A 5kvaA-5w15A:
undetectable		 5kvaA-5w15A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		4 / 6 GLN A 194
HIS A  30
VAL A  70
LEU A  78
 None
 1.33A 5xdhA-5w15A:
undetectable
5xdhC-5w15A:
undetectable		 5xdhA-5w15A:
19.70
5xdhC-5w15A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		4 / 4 HIS A  13
VAL A  70
LEU A  58
ALA A  68
 None
 1.33A 6d8pB-5w15A:
3.5		 6d8pB-5w15A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Burkholderia
ambifaria) 		5 / 12 LEU A  46
LEU A  94
ILE A 243
ALA A 263
ASP A 116
 None
 1.16A 6n91B-5w15A:
undetectable		 6n91B-5w15A:
15.56