SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 11 HIS A 178
THR A 119
THR A 116
GLY A 175
THR A 177
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
None
DGL  A 301 (-2.9A)
 1.06A 1c9sP-5w16A:
undetectable
1c9sQ-5w16A:
undetectable		 1c9sP-5w16A:
undetectable
1c9sQ-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 1gtfJ-5w16A:
undetectable
1gtfK-5w16A:
undetectable		 1gtfJ-5w16A:
undetectable
1gtfK-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 11 HIS A 178
THR A 119
THR A 116
GLY A 175
THR A 177
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
None
DGL  A 301 (-2.9A)
 1.05A 1gtfQ-5w16A:
undetectable
1gtfR-5w16A:
undetectable		 1gtfQ-5w16A:
undetectable
1gtfR-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 11 HIS A 178
THR A 119
THR A 116
GLY A 175
THR A 177
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
None
DGL  A 301 (-2.9A)
 1.07A 1gtfS-5w16A:
undetectable
1gtfT-5w16A:
undetectable		 1gtfS-5w16A:
undetectable
1gtfT-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 11 HIS A 178
THR A 119
THR A 116
GLY A 175
THR A 177
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
None
DGL  A 301 (-2.9A)
 1.08A 1gtnT-5w16A:
undetectable
1gtnU-5w16A:
undetectable		 1gtnT-5w16A:
undetectable
1gtnU-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 HIS A 178
THR A 119
THR A 116
GLY A 175
THR A 177
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
None
DGL  A 301 (-2.9A)
 1.12A 1utdE-5w16A:
undetectable
1utdF-5w16A:
undetectable		 1utdE-5w16A:
undetectable
1utdF-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 HIS A 178
THR A 119
THR A 116
GLY A 175
THR A 177
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
None
DGL  A 301 (-2.9A)
 1.11A 1utdH-5w16A:
undetectable
1utdI-5w16A:
undetectable		 1utdH-5w16A:
undetectable
1utdI-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 11 HIS A 178
THR A 119
THR A 116
GLY A 175
THR A 177
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
None
DGL  A 301 (-2.9A)
 1.08A 1utdS-5w16A:
undetectable
1utdT-5w16A:
undetectable		 1utdS-5w16A:
undetectable
1utdT-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 11 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.10A 1utdL-5w16A:
undetectable
1utdV-5w16A:
undetectable		 1utdL-5w16A:
undetectable
1utdV-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		4 / 5 LEU A 210
PHE A  33
VAL A  72
ALA A  70
 None
 1.20A 2cizA-5w16A:
undetectable		 2cizA-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		4 / 8 VAL A  42
LEU A  18
TYR A  35
HIS A 178
 NO3  A 302 (-4.9A)
None
None
DGL  A 301 ( 3.9A)
 1.00A 3af0A-5w16A:
undetectable		 3af0A-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 12 TYR A 179
GLY A  14
GLU A 145
VAL A  15
GLY A  16
 None
NO3  A 302 (-3.3A)
NO3  A 302 ( 4.0A)
NO3  A 302 (-3.6A)
None
 1.28A 3f8wB-5w16A:
undetectable		 3f8wB-5w16A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A  61
GLU A  58
LEU A  63
LEU A  64
ILE A  71
 None
 0.92A 3kvrB-5w16A:
undetectable		 3kvrB-5w16A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 12 LEU A 131
LEU A 169
GLY A 175
LEU A 174
ALA A 105
 None
 0.80A 3tbgB-5w16A:
undetectable		 3tbgB-5w16A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 12 LEU A 131
LEU A 169
GLY A 175
LEU A 174
ALA A 105
 None
 0.82A 3tbgD-5w16A:
undetectable		 3tbgD-5w16A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 12 PHE A 140
LEU A 172
GLY A 115
GLY A 175
ALA A 134
 None
 1.10A 4a6dA-5w16A:
undetectable		 4a6dA-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 12 PHE A 140
LEU A 172
GLY A 115
GLY A 175
ALA A 134
 None
 1.09A 4a6eA-5w16A:
undetectable		 4a6eA-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		3 / 3 HIS A 178
TRP A 149
SER A  13
 DGL  A 301 ( 3.9A)
None
DGL  A 301 (-2.6A)
 1.17A 4lrhD-5w16A:
undetectable		 4lrhD-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		4 / 5 ASN A  76
GLY A 175
ASP A 150
ASP A 197
 DGL  A 301 (-4.3A)
None
None
None
 1.13A 4n48B-5w16A:
undetectable		 4n48B-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5eevA-5w16A:
undetectable
5eevB-5w16A:
undetectable		 5eevA-5w16A:
undetectable
5eevB-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5eewA-5w16A:
undetectable
5eewB-5w16A:
undetectable		 5eewA-5w16A:
undetectable
5eewB-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5eexA-5w16A:
undetectable
5eexB-5w16A:
undetectable		 5eexA-5w16A:
undetectable
5eexB-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5eeyA-5w16A:
undetectable
5eeyB-5w16A:
undetectable		 5eeyA-5w16A:
undetectable
5eeyB-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5eezA-5w16A:
undetectable
5eezB-5w16A:
undetectable		 5eezA-5w16A:
undetectable
5eezB-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5ef0A-5w16A:
undetectable
5ef0B-5w16A:
undetectable		 5ef0A-5w16A:
undetectable
5ef0B-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5ef1A-5w16A:
undetectable
5ef1B-5w16A:
undetectable		 5ef1A-5w16A:
undetectable
5ef1B-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5ef2A-5w16A:
undetectable
5ef2B-5w16A:
undetectable		 5ef2A-5w16A:
undetectable
5ef2B-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		5 / 10 GLY A 175
THR A 177
HIS A 178
THR A 119
THR A 116
 None
DGL  A 301 (-2.9A)
DGL  A 301 ( 3.9A)
None
DGL  A 301 (-3.5A)
 1.15A 5ef3A-5w16A:
undetectable
5ef3B-5w16A:
undetectable		 5ef3A-5w16A:
undetectable
5ef3B-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		3 / 3 VAL A  42
TYR A  44
GLU A 145
 NO3  A 302 (-4.9A)
DGL  A 301 (-4.9A)
NO3  A 302 ( 4.0A)
 0.87A 5zmqD-5w16A:
undetectable
5zmqE-5w16A:
undetectable		 5zmqD-5w16A:
undetectable
5zmqE-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		4 / 7 VAL A  97
LEU A 113
GLY A  17
GLY A 115
 None
 0.70A 6eu9D-5w16A:
undetectable		 6eu9D-5w16A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5w16 GLUTAMATE RACEMASE
(Thermus
thermophilus) 		4 / 5 GLY A 115
THR A 116
SER A  79
SER A  80
 None
DGL  A 301 (-3.5A)
None
None
 1.15A 6jmjA-5w16A:
2.9		 6jmjA-5w16A:
undetectable