SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w19'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 6 LEU A 316
ILE A 250
ASP A 267
PRO A 268
 None
 0.84A 1ditH-5w19A:
undetectable
1ditP-5w19A:
undetectable		 1ditH-5w19A:
15.10
1ditP-5w19A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 4 VAL A 201
PHE A 167
SER A 189
VAL A 191
 None
 1.44A 1e7cA-5w19A:
undetectable		 1e7cA-5w19A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 4 LEU A 339
VAL A 357
CYH A 359
ALA A 373
 None
 1.18A 1mz9E-5w19A:
undetectable		 1mz9E-5w19A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 THR A 261
SER A 224
TYR A 254
VAL A 209
PHE A 167
 None
 1.40A 1q23C-5w19A:
undetectable		 1q23C-5w19A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 THR A 261
SER A 224
TYR A 254
VAL A 209
PHE A 167
 None
 1.47A 1q23D-5w19A:
undetectable
1q23E-5w19A:
undetectable		 1q23D-5w19A:
18.78
1q23E-5w19A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 HIS A  98
GLY A 102
ASN A 105
HIS A 138
LYS A 265
 None
None
None
None
9TD  A 502 (-4.8A)
 1.31A 1qu3A-5w19A:
undetectable		 1qu3A-5w19A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 PRO A 268
GLY A 351
ASN A 230
ILE A 250
LEU A  88
 None
 1.21A 1r30A-5w19A:
undetectable		 1r30A-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 PRO A 268
GLY A 351
ASN A 230
ILE A 250
LEU A  88
 None
 1.21A 1r30B-5w19A:
undetectable		 1r30B-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 8 VAL A 150
SER A 224
VAL A 209
VAL A 201
 None
 1.32A 2y05A-5w19A:
3.5
2y05B-5w19A:
2.9		 2y05A-5w19A:
20.48
2y05B-5w19A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 VAL A 221
ALA A 213
VAL A 276
ILE A 278
THR A 261
 None
 0.86A 3czhA-5w19A:
undetectable		 3czhA-5w19A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 VAL A 221
ALA A 257
VAL A 276
ILE A 278
THR A 261
 None
 0.84A 3czhA-5w19A:
undetectable		 3czhA-5w19A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 ALA A 257
ALA A 213
VAL A 276
ILE A 278
THR A 261
 None
 1.05A 3czhB-5w19A:
undetectable		 3czhB-5w19A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 VAL A 221
ALA A 257
VAL A 276
ILE A 278
THR A 261
 None
 0.85A 3dl9A-5w19A:
undetectable		 3dl9A-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 VAL A 221
ALA A 257
ALA A 213
ILE A 278
THR A 261
 None
 1.02A 3dl9B-5w19A:
undetectable		 3dl9B-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 ILE A 329
GLY A 352
PRO A 200
ILE A 417
PRO A 349
 None
 1.10A 3jayA-5w19A:
undetectable		 3jayA-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 GLY A 315
LEU A 269
GLN A 314
ASP A  59
SER A  58
 None
 1.34A 3tbgA-5w19A:
undetectable		 3tbgA-5w19A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 GLY A 315
LEU A 269
GLN A 314
ASP A  59
SER A  58
 None
 1.35A 3tbgC-5w19A:
undetectable		 3tbgC-5w19A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 10 THR A 261
SER A 224
TYR A 254
VAL A 209
PHE A 167
 None
 1.41A 3u9fE-5w19A:
undetectable		 3u9fE-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 10 THR A 261
SER A 224
TYR A 254
VAL A 209
PHE A 167
 None
 1.44A 3u9fD-5w19A:
undetectable
3u9fF-5w19A:
undetectable		 3u9fD-5w19A:
undetectable
3u9fF-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 10 THR A 261
SER A 224
TYR A 254
VAL A 209
PHE A 167
 None
 1.46A 3u9fI-5w19A:
0.6		 3u9fI-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 4 ASN A  77
ALA A 310
GLY A  68
THR A  67
 None
 0.91A 4bboC-5w19A:
undetectable		 4bboC-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 11 ILE A 417
THR A 416
ALA A 388
LEU A  48
LEU A 335
 None
 1.03A 4g1bB-5w19A:
undetectable		 4g1bB-5w19A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 9 ILE A 417
THR A 416
LEU A  48
VAL A 386
VAL A 357
 None
 1.08A 4g1bC-5w19A:
undetectable		 4g1bC-5w19A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 PHE A 227
ALA A 277
MET A 262
GLY A 274
LEU A 275
 None
 1.15A 4j7xB-5w19A:
undetectable		 4j7xB-5w19A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 11 LEU A 437
LEU A 380
ALA A 379
LEU A 444
VAL A 357
 None
 1.08A 4p65C-5w19A:
undetectable
4p65D-5w19A:
undetectable
4p65J-5w19A:
undetectable
4p65L-5w19A:
undetectable		 4p65C-5w19A:
undetectable
4p65D-5w19A:
undetectable
4p65J-5w19A:
undetectable
4p65L-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 11 LEU A 444
VAL A 357
LEU A 437
LEU A 380
ALA A 379
 None
 1.01A 4p65B-5w19A:
undetectable
4p65D-5w19A:
undetectable
4p65G-5w19A:
undetectable
4p65H-5w19A:
undetectable		 4p65B-5w19A:
undetectable
4p65D-5w19A:
undetectable
4p65G-5w19A:
undetectable
4p65H-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 6 ARG A   4
ILE A   5
GLN A 331
ASP A 428
 None
 1.13A 4w5tA-5w19A:
undetectable		 4w5tA-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 GLY A 319
ILE A 106
GLY A 302
LEU A  81
PHE A  89
 None
 1.15A 4zdyA-5w19A:
undetectable		 4zdyA-5w19A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 GLY A 351
THR A 350
GLU A 229
ILE A 329
ILE A 417
 None
 1.23A 4zvmA-5w19A:
undetectable
4zvmB-5w19A:
2.5		 4zvmA-5w19A:
16.96
4zvmB-5w19A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 GLY A 319
ILE A 106
GLY A 302
LEU A  81
PHE A  89
 None
 1.11A 5eqbA-5w19A:
undetectable		 5eqbA-5w19A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 ALA A 137
LEU A 456
ILE A 417
PHE A 356
GLY A 351
 None
 1.14A 5eshA-5w19A:
undetectable		 5eshA-5w19A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 6 ILE A 218
PHE A 219
PHE A 167
THR A 190
 None
None
None
9TD  A 502 ( 4.5A)
 1.17A 5g08A-5w19A:
undetectable		 5g08A-5w19A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		5 / 12 GLU A 411
GLY A 397
ALA A 146
PHE A 130
ASN A 148
 None
 1.10A 5kc4E-5w19A:
undetectable		 5kc4E-5w19A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 7 GLU A   7
PHE A   9
GLY A 330
TYR A 334
 None
 0.98A 5uxdA-5w19A:
undetectable		 5uxdA-5w19A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 6 ASN A 194
CYH A 193
PHE A 356
LEU A 395
 9TD  A 502 (-3.4A)
None
None
None
 1.10A 6a7pB-5w19A:
undetectable		 6a7pB-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5w19 TRYPTOPHANASE
(Proteus
vulgaris) 		4 / 6 ARG A   4
ILE A   5
GLN A 331
ASP A 428
 None
 1.17A 6cbdA-5w19A:
undetectable		 6cbdA-5w19A:
undetectable