SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 0.90A 1k6cB-5w1aA:
undetectable		 1k6cB-5w1aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		6 / 10 GLY A 259
ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 1.31A 1muiA-5w1aA:
undetectable		 1muiA-5w1aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ILE A 423
VAL A 605
LEU A 394
GLN A 374
PHE A 363
 None
 1.49A 1p5zB-5w1aA:
undetectable		 1p5zB-5w1aA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		4 / 6 LEU A 533
TRP A 593
LEU A 475
PHE A 577
 None
 1.48A 1ru9H-5w1aA:
undetectable
1ru9L-5w1aA:
undetectable		 1ru9H-5w1aA:
undetectable
1ru9L-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.92A 1t3rA-5w1aA:
undetectable		 1t3rA-5w1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		4 / 7 LEU A 663
PHE A 246
LEU A 176
PHE A 455
 None
 0.98A 1wrlE-5w1aA:
undetectable
1wrlF-5w1aA:
undetectable		 1wrlE-5w1aA:
20.22
1wrlF-5w1aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		3 / 3 GLY A 471
GLU A 473
ASN A 589
 None
 0.58A 1zq9A-5w1aA:
undetectable		 1zq9A-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
GLY A 457
ILE A 456
VAL A 219
 None
 1.03A 2b7zA-5w1aA:
undetectable		 2b7zA-5w1aA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
GLY A 457
ILE A 456
VAL A 219
 None
 0.97A 2b7zB-5w1aA:
undetectable		 2b7zB-5w1aA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ILE A 423
CYH A 427
LEU A 617
VAL A 383
LEU A 394
 None
 1.16A 2bxfA-5w1aA:
undetectable		 2bxfA-5w1aA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.90A 2idwB-5w1aA:
undetectable		 2idwB-5w1aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 GLY A 230
LEU A 438
ALA A 228
LEU A 338
THR A 331
 None
 1.22A 2npnA-5w1aA:
1.3		 2npnA-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 0.85A 2q5kA-5w1aA:
undetectable		 2q5kA-5w1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		6 / 9 GLY A 259
ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 1.29A 3ektA-5w1aA:
undetectable		 3ektA-5w1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 0.87A 3ekvA-5w1aA:
undetectable		 3ekvA-5w1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 11 GLN A 276
THR A 234
VAL A 235
ILE A 477
GLN A 474
 None
 1.12A 3elzB-5w1aA:
undetectable		 3elzB-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 GLN A 276
THR A 234
VAL A 235
ILE A 477
GLN A 474
 None
 1.26A 3elzC-5w1aA:
undetectable		 3elzC-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 5w1a MYOSIN LIGHT CHAIN
ALKALI
(Drosophila
melanogaster) 		5 / 9 ALA B  34
ASP B  33
GLY B  52
LEU B  50
ILE B  26
 None
 1.21A 3em4B-5w1aB:
undetectable		 3em4B-5w1aB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		4 / 6 ILE A 193
TYR A 195
ILE A 456
HIS A 250
 None
 1.22A 3eteA-5w1aA:
undetectable
3eteE-5w1aA:
undetectable		 3eteA-5w1aA:
11.66
3eteE-5w1aA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		4 / 5 ILE A 193
TYR A 195
ILE A 456
HIS A 250
 None
 1.21A 3eteB-5w1aA:
undetectable
3eteC-5w1aA:
undetectable		 3eteB-5w1aA:
11.66
3eteC-5w1aA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		4 / 6 LEU A 176
VAL A 220
VAL A 192
ILE A 247
 None
 1.19A 3k5vB-5w1aA:
undetectable		 3k5vB-5w1aA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.94A 3lzvA-5w1aA:
undetectable		 3lzvA-5w1aA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 ALA A 260
ASP A 261
GLY A 457
ILE A 456
LEU A 215
 None
 0.97A 3ogpA-5w1aA:
undetectable		 3ogpA-5w1aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 ALA A 260
ASP A 261
ILE A 262
GLY A 457
ILE A 456
 None
 0.88A 3ogpA-5w1aA:
undetectable		 3ogpA-5w1aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 1.05A 3ogpB-5w1aA:
undetectable		 3ogpB-5w1aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		6 / 10 ALA A 260
ASP A 261
ILE A 262
VAL A 219
GLY A 457
ILE A 456
 None
 1.20A 3ogqA-5w1aA:
undetectable		 3ogqA-5w1aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		6 / 10 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
LEU A 215
 None
 1.09A 3ogqA-5w1aA:
undetectable		 3ogqA-5w1aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.93A 3oy4B-5w1aA:
undetectable		 3oy4B-5w1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.92A 3s53A-5w1aA:
undetectable		 3s53A-5w1aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 1.03A 3spkB-5w1aA:
undetectable		 3spkB-5w1aA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		3 / 3 PHE A 156
CYH A 139
HIS A 154
 None
 1.27A 3u9fF-5w1aA:
undetectable		 3u9fF-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		3 / 3 PHE A 156
CYH A 139
HIS A 154
 None
 1.26A 3u9fG-5w1aA:
undetectable		 3u9fG-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		3 / 3 PHE A 156
CYH A 139
HIS A 154
 None
 1.21A 3u9fL-5w1aA:
undetectable		 3u9fL-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		3 / 3 PHE A 156
CYH A 139
HIS A 154
 None
 1.27A 3u9fS-5w1aA:
undetectable		 3u9fS-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
GLY A 457
ILE A 456
VAL A 219
 None
 1.02A 3ucbA-5w1aA:
undetectable		 3ucbA-5w1aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 11 CYH A 740
LEU A 726
ILE A 725
LEU A 769
ILE A 745
 None
 1.15A 4dm8A-5w1aA:
undetectable		 4dm8A-5w1aA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.92A 4dqeB-5w1aA:
undetectable		 4dqeB-5w1aA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.89A 4dqhB-5w1aA:
undetectable		 4dqhB-5w1aA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 9 VAL A  62
ALA A  54
LYS A  35
SER A  37
THR A  55
 None
None
None
EDO  A2003 ( 4.7A)
None
 1.12A 4eilH-5w1aA:
undetectable		 4eilH-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		4 / 6 GLY A 471
ALA A 270
GLU A 473
GLN A 572
 None
 1.00A 4g0uA-5w1aA:
undetectable		 4g0uA-5w1aA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.99A 4njtB-5w1aA:
undetectable		 4njtB-5w1aA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 0.98A 4njuA-5w1aA:
undetectable		 4njuA-5w1aA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 1.00A 4njuC-5w1aA:
undetectable		 4njuC-5w1aA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 GLY A 259
ALA A 260
ASP A 261
GLY A 457
ILE A 456
 None
 0.91A 4q1yA-5w1aA:
undetectable		 4q1yA-5w1aA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		4 / 6 PHE A 609
VAL A 605
MET A 361
ILE A 423
 None
 0.94A 5iwuA-5w1aA:
undetectable		 5iwuA-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		3 / 3 GLY A 463
ASN A 481
ARG A 672
 None
 0.79A 5w7bD-5w1aA:
undetectable		 5w7bD-5w1aA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 LEU A  97
VAL A  96
GLY A 767
PHE A  85
ASN A  81
 None
 1.34A 6a94A-5w1aA:
undetectable		 6a94A-5w1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 12 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 1.01A 6dilA-5w1aA:
undetectable		 6dilA-5w1aA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
 None
 0.87A 6dj2A-5w1aA:
undetectable		 6dj2A-5w1aA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5w1a MYOSIN HEAVY CHAIN,
MUSCLE
(Drosophila
melanogaster) 		5 / 10 ILE A 703
LEU A 106
ASP A  90
GLY A 120
MET A  94
 None
 1.37A 6r2eB-5w1aA:
undetectable		 6r2eB-5w1aA:
undetectable