SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 4 LEU A 735
PRO A 701
ILE A 786
LEU A 766
 None
 1.12A 1ya4B-5w1dA:
undetectable		 1ya4B-5w1dA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 LEU A 614
LEU A 615
LEU A 642
LEU A 665
 None
 0.97A 2ab2B-5w1dA:
undetectable		 2ab2B-5w1dA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 8 ILE A 393
GLY A 381
ARG A 477
LEU A 397
 None
 0.79A 2vctA-5w1dA:
undetectable		 2vctA-5w1dA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 4 GLN A 446
PRO A 447
VAL A 448
GLU A 385
 None
None
None
CA  A1007 (-2.9A)
 0.88A 3huoA-5w1dA:
undetectable		 3huoA-5w1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		3 / 3 ASP A 566
ARG A 574
ALA A 568
 CA  A1005 (-3.6A)
None
None
 0.78A 3mbgC-5w1dA:
undetectable		 3mbgC-5w1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 7 PHE A 458
ASN A 475
GLY A 381
PHE A 431
 None
 0.91A 4ejjB-5w1dA:
undetectable		 4ejjB-5w1dA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 7 ASP A 656
ASP A 691
ASN A 692
GLU A 606
 CA  A1003 (-3.2A)
CA  A1003 ( 2.8A)
None
CA  A1003 ( 3.0A)
 1.10A 4feuB-5w1dA:
undetectable		 4feuB-5w1dA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		5 / 11 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A1005 (-3.0A)
None
None
 1.44A 4m83A-5w1dA:
undetectable		 4m83A-5w1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 8 ARG A 450
GLU A 385
ASP A 480
GLU A 517
 None
CA  A1007 (-2.9A)
CA  A1007 (-2.7A)
K  A1006 (-2.8A)
 1.03A 6mn4B-5w1dA:
undetectable		 6mn4B-5w1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 6 ASP A 449
ARG A 450
ASP A 480
GLU A 517
 None
None
CA  A1007 (-2.7A)
K  A1006 (-2.8A)
 1.30A 6mn5D-5w1dA:
undetectable		 6mn5D-5w1dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5w1d PROTOCADHERIN-15
(Mus
musculus) 		4 / 7 ARG A 450
GLU A 385
ASP A 480
GLU A 517
 None
CA  A1007 (-2.9A)
CA  A1007 (-2.7A)
K  A1006 (-2.8A)
 1.28A 6mn5E-5w1dA:
undetectable		 6mn5E-5w1dA:
20.00