SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 THR A 147
PRO A 149
GLY A 150
LEU A 141
GLY A 115
 PHB  A 602 (-4.5A)
PHB  A 602 (-4.7A)
None
GOL  A 603 (-4.5A)
None
 1.11A 1h4oA-5w1eA:
undetectable
1h4oB-5w1eA:
undetectable		 1h4oA-5w1eA:
undetectable
1h4oB-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 SER A 220
SER A 236
VAL A 238
GLY A 150
LEU A 152
 PHB  A 602 ( 4.6A)
PHB  A 602 ( 3.9A)
PHB  A 602 (-4.7A)
None
None
 1.42A 1i9jH-5w1eA:
undetectable
1i9jL-5w1eA:
undetectable		 1i9jH-5w1eA:
16.13
1i9jL-5w1eA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 LEU A  78
VAL A  24
GLY A  21
LEU A  81
TYR A  64
 None
 1.48A 1lw0A-5w1eA:
2.3		 1lw0A-5w1eA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 LEU A  78
VAL A  24
GLY A  21
LEU A  81
TYR A  64
 None
 1.38A 1lwfA-5w1eA:
2.3		 1lwfA-5w1eA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 PHE A 312
GLY A 305
VAL A  15
LEU A  18
LEU A 330
 None
 1.00A 1mx1A-5w1eA:
undetectable		 1mx1A-5w1eA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 LEU A  28
LEU A  25
LEU A  55
LEU A  38
 None
 0.88A 2ab2A-5w1eA:
undetectable		 2ab2A-5w1eA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 THR A 147
PRO A 149
GLY A 150
LEU A 141
 PHB  A 602 (-4.5A)
PHB  A 602 (-4.7A)
None
GOL  A 603 (-4.5A)
 0.95A 2vl2B-5w1eA:
undetectable		 2vl2B-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 435
LEU A 439
ALA A 410
ALA A 477
VAL A 468
 None
 1.21A 3b0wA-5w1eA:
undetectable		 3b0wA-5w1eA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 LEU A 501
ARG A 411
LEU A 383
ALA A 482
 None
 1.04A 3b9mA-5w1eA:
2.0		 3b9mA-5w1eA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 VAL A  73
GLY A  34
PRO A 369
SER A 371
THR A 373
 None
 1.34A 3bjwE-5w1eA:
undetectable		 3bjwE-5w1eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 ALA A 148
GLY A 150
LEU A 211
SER A 236
SER A 220
 PHB  A 602 (-3.8A)
None
None
PHB  A 602 ( 3.9A)
PHB  A 602 ( 4.6A)
 0.98A 3g2oA-5w1eA:
undetectable		 3g2oA-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 GLY A 150
ILE A 123
SER A 111
LEU A 112
VAL A 234
 None
None
PHB  A 602 (-2.5A)
None
None
 1.25A 3gyqB-5w1eA:
undetectable		 3gyqB-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 GLY A 313
PHE A 518
GLY A  82
PHE A 367
 None
 0.98A 3ko0M-5w1eA:
undetectable
3ko0P-5w1eA:
undetectable		 3ko0M-5w1eA:
21.10
3ko0P-5w1eA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 10 LEU A  78
VAL A  24
GLY A  21
LEU A  81
TYR A  64
 None
 1.47A 3lp1A-5w1eA:
undetectable		 3lp1A-5w1eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 337
LYS A  12
ARG A 336
 None
 1.15A 3w1wA-5w1eA:
undetectable
3w1wB-5w1eA:
undetectable		 3w1wA-5w1eA:
undetectable
3w1wB-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 336
ARG A 337
LYS A  12
 None
 1.17A 3w1wA-5w1eA:
undetectable
3w1wB-5w1eA:
undetectable		 3w1wA-5w1eA:
undetectable
3w1wB-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 168
PHE A 178
PRO A 179
 None
 0.83A 3zoaB-5w1eA:
undetectable		 3zoaB-5w1eA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 PRO A 381
ARG A  66
GLY A  63
GLU A 511
 None
 1.09A 4g0uA-5w1eA:
3.1		 4g0uA-5w1eA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 LEU A 211
GLY A 150
LEU A 152
ALA A 218
SER A 220
 None
None
None
PHB  A 602 (-3.6A)
PHB  A 602 ( 4.6A)
 1.34A 4wnuC-5w1eA:
undetectable		 4wnuC-5w1eA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 469
ASP A 470
ARG A 474
 None
 0.63A 4wq4B-5w1eA:
undetectable		 4wq4B-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 GLY A 150
ILE A 123
SER A 111
LEU A 112
VAL A 234
 None
None
PHB  A 602 (-2.5A)
None
None
 1.11A 4x3mB-5w1eA:
undetectable		 4x3mB-5w1eA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 ASP A 401
THR A 409
PRO A 376
VAL A 398
 None
 1.07A 4yoaA-5w1eA:
undetectable		 4yoaA-5w1eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 GLU A 213
GLY A 115
ASP A 116
ARG A 121
 None
None
None
GOL  A 603 (-3.3A)
 0.94A 5cdnC-5w1eA:
2.2
5cdnD-5w1eA:
undetectable		 5cdnC-5w1eA:
10.89
5cdnD-5w1eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 VAL A 223
ASP A 225
PRO A 226
ALA A 232
 None
 0.65A 5cu6A-5w1eA:
undetectable		 5cu6A-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A 119
VAL A 114
PRO A 360
ARG A 121
GLY A  26
 None
None
None
GOL  A 603 (-3.3A)
None
 1.35A 5f9zA-5w1eA:
undetectable		 5f9zA-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 VAL A 223
ASP A 225
PRO A 226
ALA A 232
 None
 0.66A 5otrA-5w1eA:
undetectable		 5otrA-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ASP A 209
PRO A 149
ARG A 146
THR A 147
 None
PHB  A 602 (-4.7A)
None
PHB  A 602 (-4.5A)
 1.39A 5uxcA-5w1eA:
undetectable		 5uxcA-5w1eA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 121
PHE A 122
GLY A 139
 GOL  A 603 (-3.3A)
PHB  A 602 (-4.0A)
None
 0.65A 6fgdA-5w1eA:
undetectable		 6fgdA-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 SER A 402
ALA A 430
THR A 433
ALA A 397
 None
 1.17A 6ma6A-5w1eA:
undetectable		 6ma6A-5w1eA:
16.05