SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 GLY D  44
LYS D  45
GLY D  46
HIS D  42
 None
 1.31A 1mf1A-5w1kD:
undetectable		 1mf1A-5w1kD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 LEU D  65
GLY D  46
LEU D  47
GLU D  48
ASP D  91
 None
 1.25A 3tbgA-5w1kD:
undetectable		 3tbgA-5w1kD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 LEU D  65
GLY D  46
GLU D  48
ALA D  90
ASP D  91
 None
 1.09A 3tbgB-5w1kD:
undetectable		 3tbgB-5w1kD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 LEU D  65
GLY D  46
LEU D  47
GLU D  48
ASP D  91
 None
 1.27A 3tbgC-5w1kD:
undetectable		 3tbgC-5w1kD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 LEU D  65
GLY D  46
GLU D  48
ALA D  90
ASP D  91
 None
 1.09A 3tbgD-5w1kD:
undetectable		 3tbgD-5w1kD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 TYR D  34
ASP D 103
SER D  33
SER D  32
GLY D  31
 None
 1.21A 4mmdB-5w1kD:
undetectable		 4mmdB-5w1kD:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.84A 4qvpH-5w1kD:
undetectable
4qvpI-5w1kD:
undetectable		 4qvpH-5w1kD:
15.09
4qvpI-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.85A 4qvpV-5w1kD:
undetectable
4qvpW-5w1kD:
undetectable		 4qvpV-5w1kD:
15.09
4qvpW-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.88A 4qvvH-5w1kD:
undetectable		 4qvvH-5w1kD:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.88A 4qvvV-5w1kD:
undetectable		 4qvvV-5w1kD:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.87A 4qvyH-5w1kD:
undetectable		 4qvyH-5w1kD:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.87A 4qvyV-5w1kD:
undetectable
4qvyW-5w1kD:
undetectable		 4qvyV-5w1kD:
15.09
4qvyW-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.87A 4qw0H-5w1kD:
undetectable
4qw0I-5w1kD:
undetectable		 4qw0H-5w1kD:
15.09
4qw0I-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.87A 4qw0V-5w1kD:
undetectable
4qw0W-5w1kD:
undetectable		 4qw0V-5w1kD:
15.09
4qw0W-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.86A 5bxnH-5w1kD:
undetectable
5bxnI-5w1kD:
undetectable		 5bxnH-5w1kD:
15.19
5bxnI-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.87A 5cz7V-5w1kD:
undetectable
5cz7W-5w1kD:
undetectable		 5cz7V-5w1kD:
15.09
5cz7W-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.86A 5d0xV-5w1kD:
undetectable		 5d0xV-5w1kD:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.83A 5l5fH-5w1kD:
undetectable
5l5fI-5w1kD:
undetectable		 5l5fH-5w1kD:
15.09
5l5fI-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.84A 5l5fV-5w1kD:
undetectable
5l5fW-5w1kD:
undetectable		 5l5fV-5w1kD:
15.09
5l5fW-5w1kD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 PRO D 198
SER D 200
SER D 201
 None
 0.63A 6bpyA-5w1kD:
undetectable		 6bpyA-5w1kD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL D 220
THR D 218
VAL D 224
GLY D 131
VAL D 165
 None
 1.02A 6drzA-5w1kD:
undetectable		 6drzA-5w1kD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.96A 6hwdH-5w1kD:
undetectable
6hwdI-5w1kD:
undetectable		 6hwdH-5w1kD:
18.60
6hwdI-5w1kD:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5w1k CR1-10 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER D 201
GLY D 147
THR D 148
ALA D 149
THR D 144
 None
 0.96A 6hwdV-5w1kD:
undetectable		 6hwdV-5w1kD:
18.60