SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.64A 1a7yA-5w1uA:
undetectable		 1a7yA-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.52A 1a7yB-5w1uA:
undetectable		 1a7yB-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.75A 1a7yB-5w1uA:
undetectable		 1a7yB-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.58A 1dscC-5w1uA:
undetectable		 1dscC-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.73A 1dscC-5w1uA:
undetectable		 1dscC-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		7 / 12 GLY A 108
GLY A 109
GLY A 110
SER A 191
TRP A 224
PHE A 281
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.4A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.83A 1dx6A-5w1uA:
40.9		 1dx6A-5w1uA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.67A 1fjaC-5w1uA:
undetectable		 1fjaC-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.67A 1fjaD-5w1uA:
undetectable		 1fjaD-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 ILE A 106
GLY A 193
SER A 217
TYR A 416
LEU A 449
 None
 1.47A 1fm6X-5w1uA:
undetectable		 1fm6X-5w1uA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 8 LEU A 449
LEU A 468
TYR A 465
LEU A  24
 None
 1.17A 1hk2A-5w1uA:
2.6		 1hk2A-5w1uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.64A 1i3wE-5w1uA:
undetectable		 1i3wE-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.66A 1i3wE-5w1uA:
undetectable		 1i3wE-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.57A 1i3wF-5w1uA:
undetectable		 1i3wF-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.67A 1i3wG-5w1uA:
undetectable		 1i3wG-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.58A 1i3wG-5w1uA:
undetectable		 1i3wG-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.60A 1i3wH-5w1uA:
undetectable		 1i3wH-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 PHE A 210
TYR A 416
GLY A 193
ALA A 194
LEU A 201
 None
 1.13A 1igxA-5w1uA:
undetectable		 1igxA-5w1uA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 108
TYR A 105
SER A 191
TYR A 428
HIS A 442
 EPE  A 600 ( 3.9A)
None
MLI  A 601 ( 3.8A)
EPE  A 600 (-3.3A)
EPE  A 600 ( 4.0A)
 1.32A 1maaC-5w1uA:
40.3		 1maaC-5w1uA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 109
TYR A 105
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 (-3.0A)
None
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 1.46A 1maaC-5w1uA:
40.3		 1maaC-5w1uA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 109
TYR A 105
SER A 191
TYR A 428
HIS A 442
 EPE  A 600 (-3.0A)
None
MLI  A 601 ( 3.8A)
EPE  A 600 (-3.3A)
EPE  A 600 ( 4.0A)
 1.17A 1maaC-5w1uA:
40.3		 1maaC-5w1uA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 109
TYR A 121
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 (-4.2A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.94A 1maaC-5w1uA:
40.3		 1maaC-5w1uA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.61A 1mnvD-5w1uA:
undetectable		 1mnvD-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.58A 1mnvD-5w1uA:
undetectable		 1mnvD-5w1uA:
2.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 109
GLY A 110
SER A 191
PHE A 394
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 ( 4.1A)
EPE  A 600 ( 4.0A)
 0.47A 1mx1F-5w1uA:
39.2		 1mx1F-5w1uA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.60A 1ovfB-5w1uA:
undetectable		 1ovfB-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.62A 1qfiA-5w1uA:
undetectable		 1qfiA-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.82A 1qfiB-5w1uA:
undetectable		 1qfiB-5w1uA:
2.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 12 GLY A 108
GLY A 109
GLY A 110
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.80A 1qtiA-5w1uA:
40.8		 1qtiA-5w1uA:
30.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.70A 1unjF-5w1uA:
undetectable		 1unjF-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.61A 1unjF-5w1uA:
undetectable		 1unjF-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.65A 1unjL-5w1uA:
undetectable		 1unjL-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.63A 1unjL-5w1uA:
undetectable		 1unjL-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.63A 1unjR-5w1uA:
undetectable		 1unjR-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.58A 1unjR-5w1uA:
undetectable		 1unjR-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.72A 1unjW-5w1uA:
undetectable		 1unjW-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.64A 1unjX-5w1uA:
undetectable		 1unjX-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.64A 1unjX-5w1uA:
undetectable		 1unjX-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.73A 1unmE-5w1uA:
undetectable		 1unmE-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.68A 1unmE-5w1uA:
undetectable		 1unmE-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.59A 1unmF-5w1uA:
undetectable		 1unmF-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.61A 1unmF-5w1uA:
undetectable		 1unmF-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 12 GLY A 108
GLY A 109
GLY A 110
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.84A 1w6rA-5w1uA:
40.9		 1w6rA-5w1uA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 11 GLY A 109
GLY A 110
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.89A 1w76A-5w1uA:
40.8		 1w76A-5w1uA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 10 GLY A 108
GLY A 109
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.80A 1w76B-5w1uA:
40.9		 1w76B-5w1uA:
29.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 8 MET A 529
GLY A 397
LEU A 539
PRO A 350
 None
 0.77A 1ya4A-5w1uA:
39.2		 1ya4A-5w1uA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 505
THR A 502
PRO A 504
 None
 0.80A 209dC-5w1uA:
undetectable		 209dC-5w1uA:
2.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 9 GLY A 108
GLY A 109
SER A 191
ALA A 192
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
MLI  A 601 ( 3.8A)
None
EPE  A 600 ( 4.0A)
 0.84A 2aceA-5w1uA:
40.9		 2aceA-5w1uA:
30.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 9 GLY A 109
GLY A 110
SER A 191
ALA A 192
TRP A 224
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
None
MLI  A 601 (-3.4A)
EPE  A 600 ( 4.0A)
 0.46A 2aceA-5w1uA:
40.9		 2aceA-5w1uA:
30.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 9 GLY A 110
SER A 191
ALA A 192
TRP A 224
PHE A 281
 EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
None
MLI  A 601 (-3.4A)
MLI  A 601 (-3.7A)
 0.87A 2aceA-5w1uA:
40.9		 2aceA-5w1uA:
30.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 7 GLY A 109
GLY A 110
ALA A 192
TRP A 224
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
None
MLI  A 601 (-3.4A)
EPE  A 600 ( 4.0A)
 0.27A 2ha4B-5w1uA:
40.5		 2ha4B-5w1uA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 8 ALA A 524
PHE A 506
THR A 502
LYS A 507
 None
 1.05A 2kotB-5w1uA:
undetectable		 2kotB-5w1uA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 7 PHE A 111
PRO A 302
LEU A 226
PHE A 145
 None
 0.84A 2vcvL-5w1uA:
undetectable		 2vcvL-5w1uA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.82A 316dC-5w1uA:
undetectable		 316dC-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 HIS A 396
LEU A 398
VAL A 215
ILE A 316
TYR A 534
 None
 1.24A 3g9eA-5w1uA:
undetectable		 3g9eA-5w1uA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 HIS A 396
VAL A 215
ILE A 316
LEU A 539
TYR A 534
 None
 1.24A 3g9eA-5w1uA:
undetectable		 3g9eA-5w1uA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 7 GLY A 109
GLY A 110
SER A 191
TRP A 224
PHE A 394
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.4A)
MLI  A 601 ( 4.1A)
EPE  A 600 ( 4.0A)
 0.54A 3o9mA-5w1uA:
41.1		 3o9mA-5w1uA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 6 GLY A 109
GLY A 110
SER A 191
TRP A 224
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.4A)
EPE  A 600 ( 4.0A)
 0.44A 3o9mB-5w1uA:
41.1		 3o9mB-5w1uA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 ILE A 332
ASN A 382
PRO A 377
LEU A 339
 None
 1.25A 3oi8A-5w1uA:
undetectable		 3oi8A-5w1uA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 PHE A 394
LEU A 327
HIS A 190
HIS A 442
PHE A 281
 MLI  A 601 ( 4.1A)
MLI  A 601 (-4.6A)
EPE  A 600 ( 4.5A)
EPE  A 600 ( 4.0A)
MLI  A 601 (-3.7A)
 1.45A 3r2jC-5w1uA:
undetectable		 3r2jC-5w1uA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 193
GLN A 164
SER A 217
MET A 216
TYR A 121
 None
None
None
None
EPE  A 600 (-4.2A)
 0.98A 3sxjA-5w1uA:
undetectable		 3sxjA-5w1uA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 193
GLN A 164
SER A 217
MET A 216
TYR A 121
 None
None
None
None
EPE  A 600 (-4.2A)
 0.97A 3sxjB-5w1uA:
undetectable		 3sxjB-5w1uA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 7 PHE A 506
THR A 502
ASN A 499
ILE A 402
HIS A 399
 None
 1.32A 3t01A-5w1uA:
undetectable		 3t01A-5w1uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 5 ASP A  72
GLU A 113
GLY A 114
GLU A 119
 None
EPE  A 600 ( 4.9A)
None
None
 1.16A 3w9tA-5w1uA:
undetectable		 3w9tA-5w1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 ASP A  72
GLU A 113
GLY A 114
GLU A 119
 None
EPE  A 600 ( 4.9A)
None
None
 1.16A 3w9tB-5w1uA:
undetectable		 3w9tB-5w1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 5 ASP A  72
GLU A 113
GLY A 114
GLU A 119
 None
EPE  A 600 ( 4.9A)
None
None
 1.16A 3w9tC-5w1uA:
undetectable		 3w9tC-5w1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 5 ASP A  72
GLU A 113
GLY A 114
GLU A 119
 None
EPE  A 600 ( 4.9A)
None
None
 1.16A 3w9tD-5w1uA:
undetectable		 3w9tD-5w1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 ASP A  72
GLU A 113
GLY A 114
GLU A 119
 None
EPE  A 600 ( 4.9A)
None
None
 1.16A 3w9tE-5w1uA:
undetectable		 3w9tE-5w1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 5 ASP A  72
GLU A 113
GLY A 114
GLU A 119
 None
EPE  A 600 ( 4.9A)
None
None
 1.15A 3w9tG-5w1uA:
undetectable		 3w9tG-5w1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 7 LEU A 120
TYR A 428
TYR A 105
HIS A 190
 EPE  A 600 ( 3.2A)
EPE  A 600 (-3.3A)
None
EPE  A 600 ( 4.5A)
 1.15A 4arcA-5w1uA:
undetectable		 4arcA-5w1uA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 ARG A 438
GLU A 323
LEU A 326
ASP A 421
 None
 0.97A 4cevA-5w1uA:
undetectable
4cevB-5w1uA:
undetectable		 4cevA-5w1uA:
21.39
4cevB-5w1uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 ASP A 421
ARG A 438
GLU A 323
LEU A 326
 None
 0.98A 4cevA-5w1uA:
undetectable
4cevC-5w1uA:
undetectable		 4cevA-5w1uA:
21.39
4cevC-5w1uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 ARG A 438
GLU A 323
LEU A 326
ASP A 421
 None
 1.01A 4cevD-5w1uA:
1.7
4cevE-5w1uA:
1.8		 4cevD-5w1uA:
21.39
4cevE-5w1uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 ARG A 438
GLU A 323
LEU A 326
ASP A 421
 None
 1.01A 4cevE-5w1uA:
undetectable
4cevF-5w1uA:
undetectable		 4cevE-5w1uA:
21.39
4cevF-5w1uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 PHE A 210
TYR A 416
GLY A 193
ALA A 194
LEU A 201
 None
 0.90A 4e1gA-5w1uA:
0.5		 4e1gA-5w1uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 PHE A 210
TYR A 416
GLY A 193
ALA A 194
LEU A 201
 None
 0.91A 4e1gB-5w1uA:
undetectable		 4e1gB-5w1uA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 12 GLY A 108
GLY A 109
GLY A 110
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.79A 4ey6A-5w1uA:
41.0		 4ey6A-5w1uA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 12 GLY A 108
GLY A 109
GLY A 110
SER A 191
TYR A 428
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
EPE  A 600 (-3.3A)
EPE  A 600 ( 4.0A)
 1.00A 4ey6A-5w1uA:
41.0		 4ey6A-5w1uA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 12 GLY A 108
GLY A 109
GLY A 110
SER A 191
PHE A 281
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.7A)
EPE  A 600 ( 4.0A)
 0.80A 4ey6B-5w1uA:
40.7		 4ey6B-5w1uA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		6 / 12 GLY A 108
GLY A 109
GLY A 110
SER A 191
TYR A 428
HIS A 442
 EPE  A 600 ( 3.9A)
EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
EPE  A 600 (-3.3A)
EPE  A 600 ( 4.0A)
 1.02A 4ey6B-5w1uA:
40.7		 4ey6B-5w1uA:
30.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 THR A 502
PRO A 504
THR A 505
 None
 0.71A 4hivD-5w1uA:
undetectable		 4hivD-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWL_A_ASCA303_0
(DIOSCORIN 5)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 10 ASP A 312
GLN A 198
VAL A 215
THR A 401
ALA A 404
 None
 1.46A 4twlA-5w1uA:
undetectable		 4twlA-5w1uA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 10 ASP A 312
GLN A 198
VAL A 215
THR A 401
ALA A 404
 None
 1.48A 4twlB-5w1uA:
undetectable		 4twlB-5w1uA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 5 GLN A 198
HIS A 200
ILE A 202
ILE A 298
 None
 1.22A 5dnuA-5w1uA:
10.5		 5dnuA-5w1uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 5 GLN A 198
HIS A 200
ILE A 202
ILE A 298
 None
 1.18A 5dnvA-5w1uA:
9.0		 5dnvA-5w1uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 GLY A 439
GLY A 114
GLY A 109
LEU A 327
THR A 440
 None
None
EPE  A 600 (-3.0A)
MLI  A 601 (-4.6A)
None
 0.97A 5eqbA-5w1uA:
undetectable		 5eqbA-5w1uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 ASP A 124
SER A  20
TYR A  28
 None
 0.82A 5glmA-5w1uA:
undetectable		 5glmA-5w1uA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		3 / 3 MET A 297
HIS A 200
GLY A 160
 None
 0.79A 5gwzB-5w1uA:
undetectable		 5gwzB-5w1uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 ILE A 140
GLY A 114
THR A 115
LEU A 143
VAL A 264
 None
 1.13A 5hw4A-5w1uA:
undetectable		 5hw4A-5w1uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 ILE A 140
GLY A 114
THR A 115
LEU A 143
VAL A 264
 None
 1.15A 5hw4C-5w1uA:
undetectable		 5hw4C-5w1uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 5 HIS A 399
ILE A 402
PHE A 540
ALA A 406
 None
 1.14A 5msdA-5w1uA:
undetectable		 5msdA-5w1uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		5 / 12 ARG A  45
LEU A 255
GLY A 285
ILE A 240
ALA A 265
 None
 1.06A 5veuH-5w1uA:
undetectable		 5veuH-5w1uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5w1u CARBOXYLIC ESTER
HYDROLASE
(Culex
quinquefasciatus) 		4 / 6 SER A 219
ARG A 405
THR A 413
ALA A 213
 None
 1.07A 6ma6A-5w1uA:
undetectable		 6ma6A-5w1uA:
8.33