SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 8 PRO A 937
GLU A 936
GLU A 882
ASP A 883
 None
 1.19A 1dtlA-5w21A:
undetectable		 1dtlA-5w21A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 7 THR A 810
LEU A 852
GLY A 851
TYR A 894
 None
 1.06A 1gtiD-5w21A:
undetectable		 1gtiD-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 7 THR A 810
LEU A 852
GLY A 851
TYR A 894
 None
 1.01A 1gtiE-5w21A:
undetectable		 1gtiE-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 5 THR A 810
LEU A 852
GLY A 851
TYR A 894
 None
 1.12A 1gtiF-5w21A:
undetectable		 1gtiF-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 7 VAL A 590
SER A 916
PHE A 917
ALA A 922
 None
 0.76A 1j8uA-5w21A:
undetectable		 1j8uA-5w21A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 6 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.64A 1mt1A-5w21A:
undetectable
1mt1F-5w21A:
undetectable		 1mt1A-5w21A:
18.75
1mt1F-5w21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 6 ILE A 812
ARG B 198
ASP A 756
LEU A 753
 None
 0.70A 1mt1B-5w21A:
undetectable
1mt1C-5w21A:
undetectable		 1mt1B-5w21A:
20.54
1mt1C-5w21A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 6 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.72A 1mt1G-5w21A:
undetectable
1mt1J-5w21A:
undetectable		 1mt1G-5w21A:
18.75
1mt1J-5w21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 7 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.66A 1n13I-5w21A:
undetectable
1n13L-5w21A:
undetectable		 1n13I-5w21A:
18.75
1n13L-5w21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 9 PHE A 366
PHE A 332
VAL A 331
PHE A 216
LEU A 298
 None
 1.29A 1wrkA-5w21A:
undetectable
1wrkB-5w21A:
undetectable		 1wrkA-5w21A:
19.15
1wrkB-5w21A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5w21 KLOTHO
(Homo
sapiens) 		3 / 3 ASN A 304
TRP A 302
GLN A 388
 None
 1.44A 1xoqA-5w21A:
undetectable		 1xoqA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 6 LEU A 651
MET A 687
MET A 695
LEU A 703
 None
 1.30A 2oz7A-5w21A:
undetectable		 2oz7A-5w21A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 11 LEU A 398
VAL A 413
ILE A 401
PHE A 367
LEU A 324
 None
 1.25A 2q6hA-5w21A:
undetectable		 2q6hA-5w21A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5w21 KLOTHO
(Homo
sapiens) 		6 / 12 LEU A 398
VAL A 413
ILE A 401
ALA A 368
PHE A 367
LEU A 324
 None
 1.44A 2qb4A-5w21A:
undetectable		 2qb4A-5w21A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 11 LEU A 398
VAL A 413
ILE A 401
PHE A 367
LEU A 324
 None
 1.25A 2qeiA-5w21A:
undetectable		 2qeiA-5w21A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 7 ILE A 812
ARG B 198
ASP A 756
LEU A 753
 None
 0.67A 2qqcB-5w21A:
undetectable
2qqcC-5w21A:
undetectable		 2qqcB-5w21A:
23.21
2qqcC-5w21A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 7 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.74A 2qqcA-5w21A:
undetectable
2qqcF-5w21A:
undetectable		 2qqcA-5w21A:
18.75
2qqcF-5w21A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 7 ILE A 812
ARG B 198
ASP A 756
LEU A 753
 None
 0.69A 2qqcD-5w21A:
undetectable
2qqcE-5w21A:
undetectable		 2qqcD-5w21A:
23.21
2qqcE-5w21A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 7 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.67A 2qqcG-5w21A:
undetectable
2qqcJ-5w21A:
undetectable		 2qqcG-5w21A:
18.75
2qqcJ-5w21A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 7 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.71A 2qqcI-5w21A:
undetectable
2qqcL-5w21A:
undetectable		 2qqcI-5w21A:
18.75
2qqcL-5w21A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 7 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.82A 2qqdA-5w21A:
undetectable
2qqdE-5w21A:
undetectable		 2qqdA-5w21A:
19.23
2qqdE-5w21A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO
(Homo
sapiens) 		4 / 8 ILE A 812
ARG B 198
ASP A 756
LEU A 753
 None
 0.71A 2qqdB-5w21A:
undetectable
2qqdC-5w21A:
undetectable		 2qqdB-5w21A:
20.54
2qqdC-5w21A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5w21 KLOTHO
(Homo
sapiens) 		3 / 3 ASN A 406
HIS A 407
VAL A 450
 None
 0.90A 3elzB-5w21A:
undetectable		 3elzB-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 ALA A 297
LEU A 380
LEU A 375
ILE A 303
LEU A 324
 None
 0.96A 3gcsA-5w21A:
undetectable		 3gcsA-5w21A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 VAL A 278
TYR A 282
TRP A 234
LEU A 191
TYR A 219
 None
 1.22A 3mecA-5w21A:
undetectable		 3mecA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 5 TRP A 400
ILE A 303
HIS A 301
VAL A 323
 None
 0.77A 3nneB-5w21A:
0.0		 3nneB-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_D_ACTD601_0
(CHOLINE OXIDASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 5 TRP A 400
ILE A 303
HIS A 301
VAL A 323
 None
 0.78A 3nneD-5w21A:
0.0		 3nneD-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_F_ACTF601_0
(CHOLINE OXIDASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 4 TRP A 400
ILE A 303
HIS A 301
VAL A 323
 None
 0.84A 3nneF-5w21A:
0.0		 3nneF-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		3 / 3 TYR A 129
ASP A 127
ASP A 123
 None
 0.88A 3ou7B-5w21A:
undetectable		 3ou7B-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 THR A  76
SER A 128
TYR A 172
SER A  71
VAL A 185
 None
 1.39A 3u9fB-5w21A:
undetectable
3u9fC-5w21A:
undetectable		 3u9fB-5w21A:
undetectable
3u9fC-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 11 THR A  76
SER A 128
TYR A 172
SER A  71
VAL A 185
 None
 1.37A 3u9fA-5w21A:
undetectable
3u9fC-5w21A:
undetectable		 3u9fA-5w21A:
undetectable
3u9fC-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 10 THR A  76
SER A 128
TYR A 172
SER A  71
VAL A 185
 None
 1.37A 3u9fK-5w21A:
undetectable		 3u9fK-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 THR A  76
SER A 128
TYR A 172
SER A  71
VAL A 185
 None
 1.42A 3u9fJ-5w21A:
undetectable
3u9fL-5w21A:
undetectable		 3u9fJ-5w21A:
undetectable
3u9fL-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 THR A  76
SER A 128
TYR A 172
SER A  71
VAL A 185
 None
 1.39A 3u9fP-5w21A:
undetectable
3u9fS-5w21A:
undetectable		 3u9fP-5w21A:
undetectable
3u9fS-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 7 PRO A 255
ILE A  89
GLN A 201
GLY A 206
 None
 1.00A 4a3uB-5w21A:
8.5		 4a3uB-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 GLY A 505
PHE A 506
TYR A 497
TYR A 455
ASN A 415
 None
 1.28A 4a83A-5w21A:
undetectable		 4a83A-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 GLY A 505
VAL A 452
TYR A 497
TYR A 455
ASN A 415
 None
 1.09A 4a83A-5w21A:
undetectable		 4a83A-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 GLY A 952
PHE A 953
TYR A 944
TYR A 912
ASN A 873
 None
 1.39A 4a83A-5w21A:
undetectable		 4a83A-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5w21 FIBROBLAST GROWTH
FACTOR 23
(Homo
sapiens) 		4 / 7 ILE B  75
TYR B 127
HIS B 128
PHE B 157
 None
 1.06A 4a97H-5w21B:
undetectable		 4a97H-5w21B:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 7 GLY A  78
ASP A 123
GLY A 122
HIS A  95
 None
 0.94A 4c5nA-5w21A:
undetectable		 4c5nA-5w21A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 8 GLY A  78
ASP A 123
GLY A 122
HIS A  95
 None
 0.88A 4c5nC-5w21A:
undetectable		 4c5nC-5w21A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w21 FIBROBLAST GROWTH
FACTOR 23
(Homo
sapiens) 		5 / 11 HIS B  52
GLN B  67
PHE B 169
GLY B  38
GLY B  37
 None
 1.25A 4fglA-5w21B:
undetectable
4fglB-5w21B:
undetectable		 4fglA-5w21B:
undetectable
4fglB-5w21B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 10 ALA A 524
PHE A 519
LEU A 852
ILE A 895
TYR A 944
 None
 1.25A 4km0A-5w21A:
undetectable		 4km0A-5w21A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5w21 KLOTHO
(Homo
sapiens) 		3 / 3 VAL A 419
SER A 420
THR A 423
 None
 0.43A 4luhA-5w21A:
undetectable		 4luhA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 5 TYR A 478
ARG A 425
GLU A 817
VAL A 748
 None
 1.40A 4nkvB-5w21A:
undetectable		 4nkvB-5w21A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 5 ILE A 412
LEU A 369
GLU A 414
VAL A 242
 None
 1.05A 4nkxB-5w21A:
undetectable		 4nkxB-5w21A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5w21 KLOTHO
FIBROBLAST GROWTH
FACTOR 23
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP A 426
LYS A 429
LEU B 193
 ZN  A1008 (-2.2A)
None
None
 1.00A 4ptjA-5w21A:
undetectable		 4ptjA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5w21 KLOTHO
(Homo
sapiens) 		3 / 3 ASP A 381
HIS A 383
LYS A 385
 None
 0.96A 4qzuD-5w21A:
undetectable		 4qzuD-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 8 ASN A 873
ILE A 870
GLU A 897
THR A 811
 None
 0.82A 4r20A-5w21A:
undetectable		 4r20A-5w21A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 7 LEU A 806
ASN A 857
LEU A 856
ARG A 853
LEU A 852
 None
 1.45A 4wg0B-5w21A:
undetectable
4wg0C-5w21A:
undetectable		 4wg0B-5w21A:
undetectable
4wg0C-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 5 TYR A 863
LYS A 862
LEU A 753
GLU A 754
 None
 1.39A 4z4hA-5w21A:
undetectable		 4z4hA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 6 TRP A 466
THR A 374
VAL A 242
HIS A 193
 None
 0.96A 5ewuA-5w21A:
undetectable		 5ewuA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 6 TRP A 466
THR A 374
VAL A 242
HIS A 193
 None
 1.06A 5ewuB-5w21A:
undetectable		 5ewuB-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 8 ILE A 871
LEU A 856
ILE A 907
TYR A 912
 None
 0.93A 5ieoA-5w21A:
undetectable		 5ieoA-5w21A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5w21 KLOTHO
(Homo
sapiens) 		5 / 12 ALA A 706
HIS A 707
LEU A 709
ALA A 710
LEU A 637
 None
 0.97A 5k9dA-5w21A:
3.2		 5k9dA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5w21 KLOTHO
(Homo
sapiens) 		3 / 3 LYS A 424
ASP A 426
ILE A 472
 None
ZN  A1008 (-2.2A)
None
 0.83A 5kc4E-5w21A:
undetectable		 5kc4E-5w21A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 5w21 KLOTHO
(Homo
sapiens) 		4 / 8 GLU A 832
TYR A 824
PHE A 755
ARG A 751
 None
 1.21A 5oajD-5w21A:
undetectable
5oajE-5w21A:
undetectable		 5oajD-5w21A:
15.98
5oajE-5w21A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5w21 KLOTHO
(Homo
sapiens) 		3 / 3 GLU A 168
HIS A  83
ARG A 155
 None
 0.96A 5uunA-5w21A:
undetectable		 5uunA-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 7 GLY A 247
TRP A 326
TYR A 337
TYR A 192
 None
 1.21A 5vlmG-5w21A:
undetectable		 5vlmG-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5w21 KLOTHO
(Homo
sapiens) 		4 / 7 GLY A 325
PHE A 327
VAL A 331
SER A 299
 None
 1.07A 6hu9S-5w21A:
undetectable
6hu9q-5w21A:
0.1		 6hu9S-5w21A:
undetectable
6hu9q-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5w21 FIBROBLAST GROWTH
FACTOR 23
(Homo
sapiens) 		4 / 8 ASP B 109
ARG B 114
GLU B  78
ASP B  79
 None
 1.18A 6mn4A-5w21B:
undetectable		 6mn4A-5w21B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5w21 FIBROBLAST GROWTH
FACTOR 23
(Homo
sapiens) 		3 / 3 ARG B  92
PHE B 108
PHE B 103
 None
 0.96A 6nknC-5w21B:
undetectable
6nknJ-5w21B:
undetectable		 6nknC-5w21B:
undetectable
6nknJ-5w21B:
undetectable