SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		5 / 12 PRO A 517
TYR A 564
ILE A 523
VAL A 546
LEU A 556
 None
 1.28A 1z9hA-5w2fA:
2.2		 1z9hA-5w2fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		5 / 12 ARG A 568
GLY A 573
GLY A 557
ALA A 577
ASN A 551
 None
FMT  A 601 ( 4.9A)
None
None
FMT  A 603 (-3.8A)
 1.10A 3kkzB-5w2fA:
undetectable		 3kkzB-5w2fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		5 / 12 LYS A 467
GLU A 466
LEU A 435
LEU A 455
GLU A 445
 None
 0.99A 5v0vA-5w2fA:
2.1		 5v0vA-5w2fA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 5 MET A 453
ASN A 429
VAL A 433
LEU A 435
 None
 1.36A 5xdhB-5w2fA:
undetectable		 5xdhB-5w2fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 5 MET A 453
ASN A 431
VAL A 433
LEU A 435
 None
 0.80A 5xdhB-5w2fA:
undetectable		 5xdhB-5w2fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 6 VAL A 433
LEU A 460
LEU A 461
LEU A 394
 None
 1.01A 6f6sA-5w2fA:
undetectable
6f6sB-5w2fA:
undetectable		 6f6sA-5w2fA:
19.13
6f6sB-5w2fA:
16.23