SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		5 / 12 VAL A 178
GLY A 199
LEU A 202
TYR A 168
VAL A 299
 None
 1.45A 1a27A-5w2hA:
undetectable		 1a27A-5w2hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 6 GLN A 245
CYH A  98
ASP A 100
VAL A  93
 None
 1.31A 1ekjG-5w2hA:
undetectable
1ekjH-5w2hA:
undetectable		 1ekjG-5w2hA:
21.38
1ekjH-5w2hA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 7 LEU A 296
GLU A 173
LEU A 170
MET A 143
 None
 1.14A 2w8yA-5w2hA:
undetectable		 2w8yA-5w2hA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 8 VAL A  73
LYS A  75
ILE A 274
ASP A 275
 None
ADP  A 503 (-2.7A)
ADP  A 503 ( 4.3A)
MG  A 502 (-2.2A)
 0.61A 3warA-5w2hA:
3.2		 3warA-5w2hA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 6 GLU A 173
TYR A 168
ILE A 207
TYR A 291
 None
 1.15A 4qwpA-5w2hA:
undetectable		 4qwpA-5w2hA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 5 GLU A 173
TYR A 168
ILE A 207
TYR A 291
 None
 1.17A 4qwpB-5w2hA:
undetectable		 4qwpB-5w2hA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		5 / 12 TYR A  94
LEU A 106
TRP A 239
PHE A 276
SER A 251
 None
 1.44A 4yvxA-5w2hA:
undetectable		 4yvxA-5w2hA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 8 VAL A  73
LYS A  75
ILE A 274
ASP A 275
 None
ADP  A 503 (-2.7A)
ADP  A 503 ( 4.3A)
MG  A 502 (-2.2A)
 0.47A 5y9mX-5w2hA:
6.9		 5y9mX-5w2hA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 7 VAL A  73
LYS A  75
ILE A 274
ASP A 275
 None
ADP  A 503 (-2.7A)
ADP  A 503 ( 4.3A)
MG  A 502 (-2.2A)
 0.49A 5yf9B-5w2hA:
6.8		 5yf9B-5w2hA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 7 VAL A  73
LYS A  75
ILE A 274
ASP A 275
 None
ADP  A 503 (-2.7A)
ADP  A 503 ( 4.3A)
MG  A 502 (-2.2A)
 0.59A 5ywmX-5w2hA:
7.0		 5ywmX-5w2hA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		3 / 3 ARG A 272
LYS A 112
TYR A  94
 None
 1.34A 6gnaA-5w2hA:
undetectable		 6gnaA-5w2hA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		3 / 3 ARG A 272
LYS A 112
TYR A  94
 None
 1.34A 6gnbA-5w2hA:
undetectable		 6gnbA-5w2hA:
21.09