SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		5 / 10 ALA A 284
LEU A 255
PHE A 254
LEU A 218
ALA A 250
 None
 1.23A 1g5yC-5w2mA:
undetectable		 1g5yC-5w2mA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		5 / 11 ALA A 284
GLY A 317
GLU A 316
HIS A 249
GLU A 251
 None
None
None
ZN  A 801 (-3.9A)
None
 1.40A 1n6cA-5w2mA:
undetectable		 1n6cA-5w2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		5 / 10 LEU A 372
PRO A 279
SER A 278
VAL A 287
GLY A 285
 None
 1.42A 2qd2B-5w2mA:
undetectable		 2qd2B-5w2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		3 / 3 PHE A 361
ASN A 206
PHE A 336
 None
 1.07A 2zbuD-5w2mA:
undetectable		 2zbuD-5w2mA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		4 / 7 LEU A 255
VAL A 271
LEU A 218
LEU A 372
 None
 0.62A 3g8iA-5w2mA:
undetectable		 3g8iA-5w2mA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		4 / 8 PHE A 336
PHE A 302
LEU A 364
ASP A 365
 None
 0.95A 3m0wE-5w2mA:
undetectable
3m0wF-5w2mA:
undetectable
3m0wG-5w2mA:
undetectable
3m0wH-5w2mA:
undetectable		 3m0wE-5w2mA:
26.67
3m0wF-5w2mA:
26.67
3m0wG-5w2mA:
26.67
3m0wH-5w2mA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens) 		4 / 6 LEU A 357
ILE A 199
MET A 195
TRP A 217
 None
 1.33A 5ljeA-5w2mA:
undetectable		 5ljeA-5w2mA:
undetectable