SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 333
ASN A 294
VAL A 342
PHE A 352
MET A 378
 None
 1.20A 1a27A-5w3fA:
3.3		 1a27A-5w3fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 403
ASP A 397
ASP A 393
TYR A 186
 None
 1.49A 1ceaB-5w3fA:
undetectable		 1ceaB-5w3fA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 403
ASP A 397
ASP A 393
TYR A 186
 None
 1.46A 1cebA-5w3fA:
undetectable		 1cebA-5w3fA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 9 GLU A  27
LEU A  23
ARG A 244
ILE A  16
LEU A 231
 None
 1.50A 1ereB-5w3fA:
undetectable		 1ereB-5w3fA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 149
SER A 148
LEU A 142
LEU A 155
HIS A 193
 None
 1.26A 1kyvA-5w3fA:
2.5
1kyvE-5w3fA:
2.8		 1kyvA-5w3fA:
17.05
1kyvE-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 155
HIS A 193
GLY A 149
SER A 148
LEU A 142
 None
 1.30A 1kyvA-5w3fA:
2.5
1kyvB-5w3fA:
undetectable		 1kyvA-5w3fA:
17.05
1kyvB-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 277
PRO A 361
ARG A 374
TYR A 320
ILE A 292
 None
 1.27A 1mx8A-5w3fA:
undetectable		 1mx8A-5w3fA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 285
ARG A 216
LEU A 277
GLY A 300
 None
 0.93A 1n13H-5w3fA:
undetectable
1n13K-5w3fA:
undetectable		 1n13H-5w3fA:
14.67
1n13K-5w3fA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.04A 1p6kA-5w3fA:
undetectable		 1p6kA-5w3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.06A 1p6kB-5w3fA:
undetectable		 1p6kB-5w3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 244
ASP A 252
ASN A 254
GLY A 135
ARG A  65
 None
 1.34A 1q8jA-5w3fA:
2.1		 1q8jA-5w3fA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 10 GLU A  27
LEU A  23
ARG A 244
ILE A  16
LEU A 231
 None
 1.29A 1qkuA-5w3fA:
undetectable		 1qkuA-5w3fA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 10 GLU A  27
LEU A  23
ARG A 244
ILE A  16
LEU A 231
 None
 1.29A 1qkuB-5w3fA:
undetectable		 1qkuB-5w3fA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 10 GLU A  27
LEU A  23
ARG A 244
ILE A  16
LEU A 231
 None
 1.30A 1qkuC-5w3fA:
undetectable		 1qkuC-5w3fA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.07A 1rs6A-5w3fA:
undetectable		 1rs6A-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.07A 1rs6B-5w3fA:
undetectable		 1rs6B-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.08A 1rs7B-5w3fA:
undetectable		 1rs7B-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 154
GLY A 151
HIS A 140
ILE A   7
 None
 0.89A 1xf1A-5w3fA:
undetectable		 1xf1A-5w3fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 154
GLY A 151
HIS A 140
ILE A   7
 None
 0.89A 1xf1B-5w3fA:
undetectable		 1xf1B-5w3fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.05A 1zzqA-5w3fA:
undetectable		 1zzqA-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.07A 1zzqB-5w3fA:
undetectable		 1zzqB-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.09A 1zzuA-5w3fA:
0.4		 1zzuA-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.06A 1zzuB-5w3fA:
undetectable		 1zzuB-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 155
HIS A 193
GLY A 149
SER A 148
LEU A 142
 None
 1.30A 2a58A-5w3fA:
3.0
2a58B-5w3fA:
3.0		 2a58A-5w3fA:
17.05
2a58B-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 155
HIS A 193
TYR A 104
GLY A 149
LEU A 142
 None
 1.16A 2a58A-5w3fA:
3.0
2a58B-5w3fA:
3.0		 2a58A-5w3fA:
17.05
2a58B-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 155
HIS A 193
GLY A 149
SER A 148
LEU A 142
 None
 1.29A 2a58B-5w3fA:
3.0
2a58C-5w3fA:
undetectable		 2a58B-5w3fA:
17.05
2a58C-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 155
HIS A 193
TYR A 104
GLY A 149
LEU A 142
 None
 1.17A 2a58B-5w3fA:
3.0
2a58C-5w3fA:
undetectable		 2a58B-5w3fA:
17.05
2a58C-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 155
HIS A 193
TYR A 104
GLY A 149
SER A 148
LEU A 142
 None
 1.34A 2a58D-5w3fA:
2.4
2a58E-5w3fA:
undetectable		 2a58D-5w3fA:
17.05
2a58E-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 MET A 378
PHE A 203
SER A 380
ALA A 388
ASP A 206
 None
 1.36A 2avdA-5w3fA:
undetectable		 2avdA-5w3fA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 187
LEU A 142
GLY A 143
VAL A   9
ALA A 100
 None
None
GTP  A 502 ( 4.3A)
None
GTP  A 502 ( 4.8A)
 1.18A 2oz7A-5w3fA:
undetectable		 2oz7A-5w3fA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 206
TYR A 173
PRO A 176
TRP A 389
 None
 1.43A 2q6kA-5w3fA:
undetectable		 2q6kA-5w3fA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 295
SER A 274
VAL A 336
GLY A 300
VAL A 342
 None
 1.32A 2uxpB-5w3fA:
undetectable		 2uxpB-5w3fA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 409
MET A 414
ALA A 422
THR A 192
 None
 0.94A 2wx2B-5w3fA:
undetectable		 2wx2B-5w3fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 138
ILE A   7
ASN A 103
LEU A 190
THR A 191
 None
None
GTP  A 502 (-3.4A)
None
None
 1.38A 3em0B-5w3fA:
undetectable		 3em0B-5w3fA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.09A 3n62B-5w3fA:
undetectable		 3n62B-5w3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.11A 3n66B-5w3fA:
0.7		 3n66B-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 256
SER A 166
LEU A 137
PHE A  53
VAL A   4
 None
 1.27A 3u9fD-5w3fA:
undetectable
3u9fE-5w3fA:
undetectable		 3u9fD-5w3fA:
19.09
3u9fE-5w3fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 256
SER A 166
LEU A 137
PHE A  53
VAL A   4
 None
 1.29A 3u9fN-5w3fA:
undetectable
3u9fO-5w3fA:
undetectable		 3u9fN-5w3fA:
19.09
3u9fO-5w3fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 256
SER A 166
LEU A 137
PHE A  53
VAL A   4
 None
 1.33A 3u9fP-5w3fA:
undetectable		 3u9fP-5w3fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.19A 4kcnB-5w3fA:
undetectable		 4kcnB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 6 SER A 237
ARG A 244
GLY A  45
GLY A  29
 None
 1.03A 4koeA-5w3fA:
undetectable
4koeB-5w3fA:
undetectable
4koeC-5w3fA:
3.3		 4koeA-5w3fA:
25.05
4koeB-5w3fA:
25.05
4koeC-5w3fA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 SER A 380
MET A 378
ASP A 206
 None
 0.66A 4mm4B-5w3fA:
undetectable		 4mm4B-5w3fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 429
THR A 195
GLU A 169
SER A 148
GLY A 151
 None
 1.21A 4q15B-5w3fA:
undetectable		 4q15B-5w3fA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  27
LEU A  23
ARG A 244
LEU A 231
 None
 1.02A 5dxeA-5w3fA:
undetectable		 5dxeA-5w3fA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 135
GLN A 134
LEU A 379
ILE A 292
PHE A 170
 None
 1.19A 5fsaB-5w3fA:
undetectable		 5fsaB-5w3fA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  27
LEU A 218
LEU A 231
SER A 237
PRO A 361
 None
 0.98A 5hnwB-5w3fA:
54.9		 5hnwB-5w3fA:
42.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  27
LEU A 218
LEU A 231
SER A 237
PRO A 361
 None
 0.95A 5hnyB-5w3fA:
54.8		 5hnyB-5w3fA:
41.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 236
THR A 139
ASN A   8
LEU A 137
 None
 1.34A 5m0iB-5w3fA:
undetectable		 5m0iB-5w3fA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		6 / 12 GLU A  27
LEU A 218
LEU A 231
SER A 237
ARG A 321
PRO A 361
 None
 1.19A 5nd3B-5w3fA:
55.3		 5nd3B-5w3fA:
42.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.18A 5vunA-5w3fA:
undetectable		 5vunA-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.18A 5vunB-5w3fA:
undetectable		 5vunB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.15A 5vuoB-5w3fA:
undetectable		 5vuoB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 144
GLY A 107
GLY A 149
ALA A 100
ASP A  99
 GTP  A 502 (-2.8A)
None
None
GTP  A 502 ( 4.8A)
None
 0.97A 5x7fA-5w3fA:
3.6		 5x7fA-5w3fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 376
VAL A 372
PRO A 361
GLY A 322
 None
 0.99A 5x80C-5w3fA:
undetectable
5x80D-5w3fA:
undetectable		 5x80C-5w3fA:
17.31
5x80D-5w3fA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.14A 6auuB-5w3fA:
undetectable		 6auuB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 145
VAL A 189
ILE A  16
GLY A  10
ALA A 171
 GTP  A 502 (-4.6A)
None
None
GTP  A 502 (-3.6A)
None
 1.12A 6c2mA-5w3fA:
undetectable		 6c2mA-5w3fA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 145
VAL A 189
ILE A  16
GLY A  10
ALA A 171
 GTP  A 502 (-4.6A)
None
None
GTP  A 502 (-3.6A)
None
 1.18A 6c2mB-5w3fA:
undetectable		 6c2mB-5w3fA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  27
LEU A  23
ARG A 244
LEU A 231
 None
 1.06A 6cbzA-5w3fA:
undetectable		 6cbzA-5w3fA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 6 SER A 380
TYR A 313
GLN A 302
THR A 350
 None
 1.48A 6djzA-5w3fA:
undetectable		 6djzA-5w3fA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 THR A 192
TYR A 186
ALA A 401
LEU A 426
ASP A 397
 None
 1.04A 6ie8A-5w3fA:
undetectable		 6ie8A-5w3fA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 112
GLY A 149
LEU A 150
GLU A 157
 None
 0.80A 6mdqA-5w3fA:
undetectable		 6mdqA-5w3fA:
11.84