SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5w3l C5 ANTIBODY VARIABLE
HEAVY DOMAIN
C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY G 101
GLY G 100
GLY G  99
LEU E  45
SER G   7
 None
 1.04A 1xdsA-5w3lG:
undetectable		 1xdsA-5w3lG:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5w3l C5 ANTIBODY VARIABLE
HEAVY DOMAIN
C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY G 101
GLY G 100
GLY G  99
LEU E  45
SER G   7
 None
 1.03A 1xdsB-5w3lG:
undetectable		 1xdsB-5w3lG:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		5 / 11 VAL B 101
TRP B 107
ILE B  87
LEU B  97
LEU B  44
 None
 1.12A 2a15A-5w3lB:
undetectable		 2a15A-5w3lB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		5 / 12 ALA B 213
LEU B 111
LEU B  97
LEU B  96
LEU B 219
 None
 0.94A 2jfaB-5w3lB:
undetectable		 2jfaB-5w3lB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 5w3l C5 ANTIBODY VARIABLE
HEAVY DOMAIN
VIRAL PROTEIN 3
(Mus
musculus;
Rhinovirus
B) 		3 / 3 TRP B 190
GLN B 192
TRP E  52
 None
 1.22A 2vqyA-5w3lB:
undetectable		 2vqyA-5w3lB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5w3l C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Mus
musculus) 		4 / 7 LEU G  33
ALA G  72
GLY G  64
PHE G  91
 None
 0.94A 2wq5A-5w3lG:
undetectable		 2wq5A-5w3lG:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		4 / 8 GLN B  79
GLY B  82
GLY B 148
MET B 163
 None
 0.87A 2y6rB-5w3lB:
undetectable		 2y6rB-5w3lB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		4 / 5 GLN B 226
THR B 225
GLU B  99
THR B  95
 None
 0.96A 3glqA-5w3lB:
undetectable		 3glqA-5w3lB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		5 / 10 ILE B 211
PHE B  92
ILE B  87
ILE B 165
SER B 209
 None
 1.26A 3o1xA-5w3lB:
undetectable		 3o1xA-5w3lB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5w3l C5 ANTIBODY VARIABLE
HEAVY DOMAIN
C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Mus
musculus;
Mus
musculus) 		5 / 11 ALA E  35
TYR E  94
ALA G  34
TYR G  36
TYR E 102
 None
 1.38A 3qxyB-5w3lE:
undetectable
3qxyQ-5w3lE:
undetectable		 3qxyB-5w3lE:
14.05
3qxyQ-5w3lE:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5w3l C5 ANTIBODY VARIABLE
HEAVY DOMAIN
C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Mus
musculus;
Mus
musculus) 		5 / 11 VAL E  34
ALA E  35
TYR E  94
ALA G  34
TYR G  36
 None
 1.40A 3qxyB-5w3lE:
undetectable
3qxyQ-5w3lE:
undetectable		 3qxyB-5w3lE:
14.05
3qxyQ-5w3lE:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5w3l C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Mus
musculus) 		5 / 12 PHE G  83
GLN G  37
LEU G  73
VAL G  19
ILE G  75
 None
 1.05A 4k38B-5w3lG:
undetectable		 4k38B-5w3lG:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		3 / 3 PRO B  70
ASN B  56
HIS B  59
 None
 1.00A 4ma3H-5w3lB:
undetectable
4ma3L-5w3lB:
undetectable		 4ma3H-5w3lB:
20.73
4ma3L-5w3lB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		4 / 5 ILE B  47
LEU B  97
ASP B 216
VAL B 162
 None
 1.07A 4nkxB-5w3lB:
undetectable		 4nkxB-5w3lB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		3 / 3 LYS B 218
ARG B 220
HIS B 106
 None
 0.88A 4zbrA-5w3lB:
undetectable		 4zbrA-5w3lB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5w3l VIRAL PROTEIN 3
C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Rhinovirus
B;
Mus
musculus) 		5 / 12 THR G  94
THR B 202
THR B 201
ARG B  75
ALA B  73
 None
 1.16A 5lf7V-5w3lG:
undetectable
5lf7b-5w3lG:
undetectable		 5lf7V-5w3lG:
23.83
5lf7b-5w3lG:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5w3l VIRAL PROTEIN 3
C5 ANTIBODY VARIABLE
LIGHT DOMAIN
(Rhinovirus
B;
Mus
musculus) 		5 / 12 THR G  94
THR B 202
THR B 201
ARG B  75
ALA B  73
 None
 1.16A 5lf7H-5w3lG:
undetectable
5lf7N-5w3lG:
undetectable		 5lf7H-5w3lG:
23.83
5lf7N-5w3lG:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5w3l VIRAL PROTEIN 3
(Rhinovirus
B) 		4 / 8 TYR B 117
THR B 193
CYH B 189
TRP B 153
 None
 1.47A 6cnjD-5w3lB:
undetectable
6cnjE-5w3lB:
undetectable		 6cnjD-5w3lB:
18.06
6cnjE-5w3lB:
17.90