SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 12 HIS A 199
LEU A 226
PHE A 229
HIS A  22
HIS A  24
 CO  A 402 (-3.1A)
None
EDO  A 403 (-4.5A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 1.36A 1a4lB-5w3wA:
14.3		 1a4lB-5w3wA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 213
ASP A 214
LEU A 196
ILE A 253
LEU A 242
 None
 1.21A 1errA-5w3wA:
undetectable		 1errA-5w3wA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 256
HIS A 199
HIS A  22
 FE  A 401 (-2.4A)
CO  A 402 (-3.1A)
FE  A 401 (-3.3A)
 0.66A 1oe1A-5w3wA:
undetectable		 1oe1A-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 256
HIS A 199
HIS A  22
 FE  A 401 (-2.4A)
CO  A 402 (-3.1A)
FE  A 401 (-3.3A)
 0.66A 1oe3A-5w3wA:
undetectable		 1oe3A-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 ASN A 176
ASN A 175
ILE A 145
GLY A 144
 None
 0.80A 1oniA-5w3wA:
undetectable
1oniB-5w3wA:
undetectable		 1oniA-5w3wA:
undetectable
1oniB-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 ASN A 176
ASN A 175
ILE A 145
GLY A 144
 None
 0.82A 1oniD-5w3wA:
undetectable
1oniF-5w3wA:
undetectable		 1oniD-5w3wA:
undetectable
1oniF-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 11 ILE A  88
LEU A  90
GLY A  93
ASP A 121
VAL A   6
 None
 1.13A 2fxdA-5w3wA:
undetectable		 2fxdA-5w3wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 256
HIS A 199
HIS A  22
 FE  A 401 (-2.4A)
CO  A 402 (-3.1A)
FE  A 401 (-3.3A)
 0.69A 2xxgA-5w3wA:
undetectable		 2xxgA-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 256
HIS A 199
HIS A  22
 FE  A 401 (-2.4A)
CO  A 402 (-3.1A)
FE  A 401 (-3.3A)
 0.69A 2xxgC-5w3wA:
undetectable		 2xxgC-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 7 ILE A  21
ILE A 288
LEU A 196
PHE A 218
 None
 0.99A 3adxA-5w3wA:
undetectable		 3adxA-5w3wA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 VAL A  50
LYS A  54
GLN A  58
GLY A  60
 None
 0.85A 3bjwE-5w3wA:
undetectable		 3bjwE-5w3wA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 7 VAL A  50
LYS A  54
GLN A  58
GLY A  60
 None
 0.69A 3bjwH-5w3wA:
undetectable		 3bjwH-5w3wA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 7 GLY A  93
ASP A 121
ILE A 122
VAL A 165
 None
 0.81A 3fi0E-5w3wA:
undetectable		 3fi0E-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 144
ALA A 140
THR A 169
ILE A 197
ILE A 209
 None
 1.40A 3ld6A-5w3wA:
undetectable		 3ld6A-5w3wA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 GLU A  30
PRO A  67
ARG A  74
GLY A  73
 None
KCX  A 137 ( 4.6A)
None
None
 1.14A 3oxvA-5w3wA:
undetectable		 3oxvA-5w3wA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 9 ARG A 235
ASP A 249
ILE A 197
ILE A 253
ILE A 251
 None
 1.11A 3s56B-5w3wA:
undetectable		 3s56B-5w3wA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 12 GLU A 285
PHE A  59
ASP A 286
ASN A 236
SER A 279
 None
 1.48A 4djfB-5w3wA:
5.2		 4djfB-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 8 ASN A 236
PHE A 305
ILE A 301
PHE A  18
 None
 0.93A 4fglD-5w3wA:
undetectable		 4fglD-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 9 TYR A 208
ILE A 212
ASP A 222
GLY A 201
THR A 239
 None
 1.27A 4r1zA-5w3wA:
undetectable		 4r1zA-5w3wA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 6 HIS A  22
HIS A  24
HIS A 170
HIS A 199
ASP A 256
 FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
CO  A 402 (-3.1A)
CO  A 402 (-3.1A)
FE  A 401 (-2.4A)
 0.68A 4ubpC-5w3wA:
13.1		 4ubpC-5w3wA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 5 ILE A 167
GLY A 198
ILE A 138
LEU A 196
 None
None
KCX  A 137 ( 3.7A)
None
 0.93A 5dzkd-5w3wA:
2.3
5dzkk-5w3wA:
2.0
5dzky-5w3wA:
undetectable		 5dzkd-5w3wA:
undetectable
5dzkk-5w3wA:
undetectable
5dzky-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 111
LEU A 185
ILE A 184
GLY A 144
PRO A 143
 None
 1.10A 5ienA-5w3wA:
undetectable		 5ienA-5w3wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  71
ASP A 256
HIS A  24
SER A 171
TYR A  99
 None
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
EDO  A 404 (-4.5A)
 1.23A 5igvA-5w3wA:
undetectable		 5igvA-5w3wA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  71
ASP A 256
HIS A  24
SER A 171
TYR A  99
 None
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
EDO  A 404 (-4.5A)
 1.17A 5igwA-5w3wA:
undetectable		 5igwA-5w3wA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 HIS A  22
ASP A 256
HIS A  24
TRP A  97
 FE  A 401 (-3.3A)
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
 1.49A 5m45A-5w3wA:
0.0		 5m45A-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 HIS A  22
ASP A 256
HIS A  24
TRP A  97
 FE  A 401 (-3.3A)
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
 1.49A 5m45D-5w3wA:
undetectable		 5m45D-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 HIS A  22
ASP A 256
HIS A  24
TRP A  97
 FE  A 401 (-3.3A)
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
 1.49A 5m45G-5w3wA:
undetectable		 5m45G-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 6 HIS A  22
ASP A 256
HIS A  24
TRP A  97
 FE  A 401 (-3.3A)
FE  A 401 (-2.4A)
FE  A 401 (-3.2A)
None
 1.49A 5m45J-5w3wA:
0.0		 5m45J-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 256
HIS A 174
HIS A  22
ASP A 141
 FE  A 401 (-2.4A)
EDO  A 403 (-4.5A)
FE  A 401 (-3.3A)
None
 1.19A 6mn4C-5w3wA:
undetectable		 6mn4C-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 256
HIS A 174
HIS A  22
ASP A 141
 FE  A 401 (-2.4A)
EDO  A 403 (-4.5A)
FE  A 401 (-3.3A)
None
 1.16A 6mn4D-5w3wA:
undetectable		 6mn4D-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5w3w ARYLDIALKYLPHOSPHATA
SE
(Sulfolobus
solfataricus) 		5 / 10 THR A 177
GLY A 198
GLN A 181
ASN A 172
PHE A 229
 None
None
None
EDO  A 403 (-3.4A)
EDO  A 403 (-4.5A)
 1.41A 6nqaK-5w3wA:
undetectable		 6nqaK-5w3wA:
undetectable