SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		5 / 12 GLY A 385
SER A 390
LEU A 324
SER A 325
LEU A 281
 None
None
SCY  A 321 ( 4.8A)
SCY  A 321 ( 3.0A)
COA  A 502 (-4.5A)
 1.00A 1ya4A-5w40A:
undetectable		 1ya4A-5w40A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		4 / 6 GLU A 284
TYR A 290
ARG A 282
LYS A 283
 None
 1.14A 1yc2A-5w40A:
undetectable
1yc2B-5w40A:
undetectable
1yc2E-5w40A:
undetectable		 1yc2A-5w40A:
23.14
1yc2B-5w40A:
23.14
1yc2E-5w40A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		3 / 3 PRO A 311
ASP A 279
GLU A 284
 None
 0.66A 3v4tC-5w40A:
undetectable		 3v4tC-5w40A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		4 / 6 ARG A 454
ASP A 182
VAL A 450
ASP A 320
 None
 1.39A 4xqeA-5w40A:
undetectable		 4xqeA-5w40A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		4 / 6 ARG A 454
ASP A 182
VAL A 450
ASP A 320
 None
 1.40A 4xqeB-5w40A:
undetectable		 4xqeB-5w40A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		5 / 12 PRO A 183
ILE A 323
VAL A 193
VAL A 190
LEU A 326
 None
 1.27A 5bykA-5w40A:
undetectable		 5bykA-5w40A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		4 / 6 SER A 447
SER A 317
ASP A 182
PRO A 183
 None
COA  A 502 (-4.8A)
None
None
 1.16A 5c6pA-5w40A:
undetectable		 5c6pA-5w40A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		4 / 6 VAL A 356
HIS A 355
LEU A 376
LEU A 346
 None
 1.26A 5hrqB-5w40A:
undetectable
5hrqI-5w40A:
undetectable
5hrqJ-5w40A:
undetectable		 5hrqB-5w40A:
6.02
5hrqI-5w40A:
4.61
5hrqJ-5w40A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		5 / 12 PRO A 183
ILE A 323
VAL A 193
VAL A 190
LEU A 326
 None
 1.19A 6b52A-5w40A:
undetectable		 6b52A-5w40A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5w40 POPP2 PROTEIN
(Ralstonia
solanacearum) 		3 / 3 ARG A 322
LYS A 322
ARG A 416
 SCY  A 321 ( 4.0A)
SCY  A 321 ( 3.0A)
IHP  A 501 (-3.5A)
 1.30A 6c06D-5w40A:
undetectable		 6c06D-5w40A:
undetectable