SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		3 / 3 GLU A 159
THR A 147
LEU A 181
 None
 0.67A 1v8bC-5w4aA:
undetectable		 1v8bC-5w4aA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		5 / 9 ASP A 171
THR A 147
GLU A 159
ILE A 140
LEU A 144
 None
 1.29A 3hy7B-5w4aA:
undetectable		 3hy7B-5w4aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		3 / 3 ARG A 194
ASP A 202
ASP A 195
 None
 0.89A 3jayA-5w4aA:
undetectable		 3jayA-5w4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		3 / 3 ARG A  15
ARG A 200
ILE A   8
 None
 0.60A 4b7qA-5w4aA:
undetectable		 4b7qA-5w4aA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		3 / 3 ARG A  15
ARG A 200
ILE A   8
 None
 0.64A 4b7qC-5w4aA:
undetectable		 4b7qC-5w4aA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		4 / 5 PHE A 197
ILE A  14
GLY A  13
THR A 204
 None
 1.00A 4ejjC-5w4aA:
undetectable		 4ejjC-5w4aA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		5 / 9 THR A 147
LEU A 144
ALA A  83
LEU A  81
LEU A 163
 None
 1.44A 4ltwA-5w4aA:
undetectable		 4ltwA-5w4aA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		4 / 7 THR A  73
THR A  80
LEU A  81
THR A  76
 None
None
None
EDO  A 304 (-3.4A)
 0.96A 4z91F-5w4aA:
undetectable
4z91G-5w4aA:
undetectable
4z91H-5w4aA:
undetectable
4z91I-5w4aA:
undetectable
4z91J-5w4aA:
undetectable		 4z91F-5w4aA:
12.77
4z91G-5w4aA:
12.77
4z91H-5w4aA:
12.77
4z91I-5w4aA:
12.77
4z91J-5w4aA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		5 / 11 PHE A 170
LEU A  64
LEU A  22
PHE A 175
THR A  80
 None
 1.17A 4zmeA-5w4aA:
undetectable		 4zmeA-5w4aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5w4a P-GRANULE SCAFFOLD
(Caenorhabditis
japonica) 		5 / 10 PHE A 170
LEU A  64
LEU A  22
PHE A 175
THR A  80
 None
 1.17A 4zmeB-5w4aA:
undetectable		 4zmeB-5w4aA:
15.31