SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.71A 1d4fA-5w4bA:
42.1		 1d4fA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
9W4  A 502 (-3.6A)
None
 0.51A 1d4fA-5w4bA:
42.1		 1d4fA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
 0.97A 1d4fA-5w4bA:
42.1		 1d4fA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 344
LEU A 347
GLY A 352
MET A 358
 None
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
 0.75A 1d4fA-5w4bA:
42.1		 1d4fA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
HIS A  55
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
None
None
NAD  A 501 (-4.1A)
None
 0.79A 1d4fB-5w4bA:
53.5		 1d4fB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
GLU A  59
ASP A 131
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-3.8A)
None
None
9W4  A 502 (-3.6A)
None
 0.55A 1d4fB-5w4bA:
53.5		 1d4fB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
 0.93A 1d4fB-5w4bA:
53.5		 1d4fB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 344
LEU A 347
GLY A 352
MET A 358
 None
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
 0.71A 1d4fB-5w4bA:
53.5		 1d4fB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 THR A  57
THR A  60
GLU A 156
HIS A 353
 9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.5A)
 0.94A 1d4fB-5w4bA:
53.5		 1d4fB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 THR A  57
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-2.9A)
None
None
None
 0.83A 1d4fB-5w4bA:
53.5		 1d4fB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLU A  59
LYS A 186
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.66A 1d4fC-5w4bA:
53.5		 1d4fC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.68A 1d4fC-5w4bA:
53.5		 1d4fC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
9W4  A 502 (-3.6A)
None
 0.46A 1d4fC-5w4bA:
53.5		 1d4fC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.96A 1d4fC-5w4bA:
53.5		 1d4fC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.95A 1d4fC-5w4bA:
53.5		 1d4fC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.37A 1d4fC-5w4bA:
53.5		 1d4fC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.74A 1d4fD-5w4bA:
53.7		 1d4fD-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
9W4  A 502 (-3.6A)
None
 0.53A 1d4fD-5w4bA:
53.7		 1d4fD-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.94A 1d4fD-5w4bA:
53.7		 1d4fD-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
 0.98A 1d4fD-5w4bA:
53.7		 1d4fD-5w4bA:
96.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ILE A 295
THR A 274
ILE A 299
ASN A 346
LEU A 199
 None
None
NAD  A 501 (-4.3A)
NAD  A 501 (-3.1A)
None
 1.15A 1dhfB-5w4bA:
3.8		 1dhfB-5w4bA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLY A 220
ALA A 219
ILE A 282
ILE A 299
ILE A 281
 NAD  A 501 ( 3.7A)
None
None
NAD  A 501 (-4.3A)
NAD  A 501 (-4.8A)
 0.88A 1hshC-5w4bA:
undetectable		 1hshC-5w4bA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ALA A 177
ILE A 178
ILE A 153
LEU A  63
GLN A 369
 None
 0.92A 1uduB-5w4bA:
undetectable		 1uduB-5w4bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 8 LEU A 338
VAL A 296
THR A 274
ASP A 307
 None
 0.95A 1uyuA-5w4bA:
undetectable		 1uyuA-5w4bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 8 LEU A 338
VAL A 296
THR A 274
ASP A 307
 None
 0.96A 1uyuB-5w4bA:
undetectable		 1uyuB-5w4bA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.92A 1v8bA-5w4bA:
40.7		 1v8bA-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.72A 1v8bA-5w4bA:
40.7		 1v8bA-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.92A 1v8bA-5w4bA:
40.7		 1v8bA-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.87A 1v8bA-5w4bA:
40.7		 1v8bA-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 1v8bB-5w4bA:
47.0		 1v8bB-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.73A 1v8bB-5w4bA:
47.0		 1v8bB-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 1v8bB-5w4bA:
47.0		 1v8bB-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.86A 1v8bB-5w4bA:
47.0		 1v8bB-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 THR A 157
LYS A 186
ASP A 190
GLY A 352
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 1.07A 1v8bB-5w4bA:
47.0		 1v8bB-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 THR A 157
LYS A 186
ASP A 190
LEU A 347
GLY A 352
MET A 358
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
 1.18A 1v8bB-5w4bA:
47.0		 1v8bB-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
GLU A  59
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.69A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.85A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 1v8bD-5w4bA:
46.8		 1v8bD-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 1v8bD-5w4bA:
46.8		 1v8bD-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 1v8bD-5w4bA:
46.8		 1v8bD-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.86A 1v8bD-5w4bA:
46.8		 1v8bD-5w4bA:
51.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		3 / 3 HIS A 162
ASP A 131
ASN A  80
 None
None
9W4  A 502 (-3.3A)
 0.80A 1wg8B-5w4bA:
4.8		 1wg8B-5w4bA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 GLU A  59
ASP A 131
ASP A 190
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.82A 1xwfA-5w4bA:
58.7		 1xwfA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 GLU A  59
ASP A 190
LEU A 344
LEU A 347
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.67A 1xwfA-5w4bA:
58.7		 1xwfA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A  54
HIS A  55
ASP A 131
ASP A 190
LEU A 347
 None
9W4  A 502 (-3.7A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
 1.14A 1xwfA-5w4bA:
58.7		 1xwfA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.57A 1xwfA-5w4bA:
58.7		 1xwfA-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 GLU A  59
ASP A 131
ASP A 190
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.80A 1xwfB-5w4bA:
58.7		 1xwfB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 GLU A  59
ASP A 190
LEU A 344
LEU A 347
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.64A 1xwfB-5w4bA:
58.7		 1xwfB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A  54
HIS A  55
ASP A 131
ASP A 190
LEU A 347
 None
9W4  A 502 (-3.7A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
 1.17A 1xwfB-5w4bA:
58.7		 1xwfB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.59A 1xwfB-5w4bA:
58.7		 1xwfB-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 GLU A  59
ASP A 131
ASP A 190
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.77A 1xwfC-5w4bA:
58.8		 1xwfC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 GLU A  59
ASP A 190
LEU A 344
LEU A 347
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.61A 1xwfC-5w4bA:
58.8		 1xwfC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A  54
HIS A  55
ASP A 131
ASP A 190
LEU A 347
 None
9W4  A 502 (-3.7A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
 1.14A 1xwfC-5w4bA:
58.8		 1xwfC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.56A 1xwfC-5w4bA:
58.8		 1xwfC-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 GLU A  59
ASP A 131
ASP A 190
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.76A 1xwfD-5w4bA:
58.9		 1xwfD-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 GLU A  59
ASP A 190
LEU A 344
LEU A 347
GLY A 352
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.61A 1xwfD-5w4bA:
58.9		 1xwfD-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A  54
HIS A  55
ASP A 131
ASP A 190
LEU A 347
 None
9W4  A 502 (-3.7A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
 1.15A 1xwfD-5w4bA:
58.9		 1xwfD-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.58A 1xwfD-5w4bA:
58.9		 1xwfD-5w4bA:
96.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 THR A  57
GLU A  59
ASP A 190
LEU A 347
MET A 358
PHE A 362
 9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.71A 1xwfD-5w4bA:
58.9		 1xwfD-5w4bA:
96.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 11 GLY A 220
ALA A 219
ILE A 282
ILE A 299
ILE A 281
 NAD  A 501 ( 3.7A)
None
None
NAD  A 501 (-4.3A)
NAD  A 501 (-4.8A)
 0.93A 2b60B-5w4bA:
undetectable		 2b60B-5w4bA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 10 LYS A 142
GLU A 115
TYR A 143
LEU A 118
GLY A 123
 None
 1.47A 2b82A-5w4bA:
2.7		 2b82A-5w4bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_B_ADNB1002_1
(CLASS B ACID
PHOSPHATASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 9 LYS A 142
GLU A 115
TYR A 143
LEU A 118
GLY A 123
 None
 1.45A 2b82B-5w4bA:
2.7		 2b82B-5w4bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLY A 220
ALA A 219
ILE A 282
ILE A 299
ILE A 281
 NAD  A 501 ( 3.7A)
None
None
NAD  A 501 (-4.3A)
NAD  A 501 (-4.8A)
 0.85A 2rkfA-5w4bA:
undetectable		 2rkfA-5w4bA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 7 LEU A 338
VAL A 296
THR A 274
ASP A 307
 None
 0.96A 2zaxA-5w4bA:
undetectable		 2zaxA-5w4bA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.73A 2zj0A-5w4bA:
46.0		 2zj0A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.67A 2zj0A-5w4bA:
46.0		 2zj0A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.92A 2zj0A-5w4bA:
46.0		 2zj0A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 2zj0A-5w4bA:
46.0		 2zj0A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.93A 2zj0A-5w4bA:
46.0		 2zj0A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.73A 2zj0B-5w4bA:
46.4		 2zj0B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 2zj0B-5w4bA:
46.4		 2zj0B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.94A 2zj0B-5w4bA:
46.4		 2zj0B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.07A 2zj0B-5w4bA:
46.4		 2zj0B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 2zj0C-5w4bA:
46.3		 2zj0C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.71A 2zj0C-5w4bA:
46.3		 2zj0C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.69A 2zj0C-5w4bA:
46.3		 2zj0C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.97A 2zj0C-5w4bA:
46.3		 2zj0C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.05A 2zj0C-5w4bA:
46.3		 2zj0C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.32A 2zj0C-5w4bA:
46.3		 2zj0C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
None
 0.73A 2zj0D-5w4bA:
46.1		 2zj0D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.68A 2zj0D-5w4bA:
46.1		 2zj0D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.98A 2zj0D-5w4bA:
46.1		 2zj0D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.94A 2zj0D-5w4bA:
46.1		 2zj0D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.94A 2zj0D-5w4bA:
46.1		 2zj0D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.79A 3ce6A-5w4bA:
46.2		 3ce6A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 3ce6A-5w4bA:
46.2		 3ce6A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.97A 3ce6A-5w4bA:
46.2		 3ce6A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.95A 3ce6A-5w4bA:
46.2		 3ce6A-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.81A 3ce6B-5w4bA:
40.7		 3ce6B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.74A 3ce6B-5w4bA:
40.7		 3ce6B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.97A 3ce6B-5w4bA:
40.7		 3ce6B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.08A 3ce6B-5w4bA:
40.7		 3ce6B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.98A 3ce6B-5w4bA:
40.7		 3ce6B-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.75A 3ce6C-5w4bA:
46.2		 3ce6C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 3ce6C-5w4bA:
46.2		 3ce6C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.97A 3ce6C-5w4bA:
46.2		 3ce6C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.95A 3ce6C-5w4bA:
46.2		 3ce6C-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
None
9W4  A 502 (-3.6A)
None
 0.83A 3ce6D-5w4bA:
46.2		 3ce6D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.78A 3ce6D-5w4bA:
46.2		 3ce6D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.41A 3ce6D-5w4bA:
46.2		 3ce6D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.97A 3ce6D-5w4bA:
46.2		 3ce6D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.95A 3ce6D-5w4bA:
46.2		 3ce6D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.99A 3ce6D-5w4bA:
46.2		 3ce6D-5w4bA:
55.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
ASP A 190
LEU A 347
MET A 358
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 (-3.6A)
 1.17A 3ce6D-5w4bA:
46.2		 3ce6D-5w4bA:
55.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 4 ILE A 200
GLN A 230
ILE A 271
LEU A 192
 None
 1.21A 3dzyD-5w4bA:
undetectable		 3dzyD-5w4bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 PRO A 354
VAL A 357
THR A 275
GLY A 225
 None
 0.95A 3elzB-5w4bA:
undetectable		 3elzB-5w4bA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 7 LYS A 426
ASN A 360
HIS A 398
ALA A 397
 None
 1.38A 3frqB-5w4bA:
undetectable		 3frqB-5w4bA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 7 LEU A 338
VAL A 296
THR A 274
ASP A 307
 None
 0.96A 3fwgB-5w4bA:
undetectable		 3fwgB-5w4bA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 3g1uA-5w4bA:
37.2		 3g1uA-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
9W4  A 502 (-3.6A)
None
 0.91A 3g1uA-5w4bA:
37.2		 3g1uA-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.84A 3g1uA-5w4bA:
37.2		 3g1uA-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.78A 3g1uA-5w4bA:
37.2		 3g1uA-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.68A 3g1uB-5w4bA:
50.0		 3g1uB-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
9W4  A 502 (-3.6A)
None
 0.56A 3g1uB-5w4bA:
50.0		 3g1uB-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.80A 3g1uB-5w4bA:
50.0		 3g1uB-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.70A 3g1uC-5w4bA:
50.6		 3g1uC-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.65A 3g1uC-5w4bA:
50.6		 3g1uC-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.96A 3g1uC-5w4bA:
50.6		 3g1uC-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
 1.09A 3g1uC-5w4bA:
50.6		 3g1uC-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A  57
LYS A 186
ASP A 190
LEU A 347
PHE A 362
 9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
None
 1.41A 3g1uC-5w4bA:
50.6		 3g1uC-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.80A 3g1uD-5w4bA:
46.4		 3g1uD-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 3g1uD-5w4bA:
46.4		 3g1uD-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.64A 3g1uD-5w4bA:
46.4		 3g1uD-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
THR A  57
ASP A 131
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.87A 3g1uD-5w4bA:
46.4		 3g1uD-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A  57
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 9W4  A 502 (-2.9A)
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.33A 3g1uD-5w4bA:
46.4		 3g1uD-5w4bA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.93A 3glqA-5w4bA:
48.6		 3glqA-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.72A 3glqA-5w4bA:
48.6		 3glqA-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.99A 3glqA-5w4bA:
48.6		 3glqA-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.06A 3glqA-5w4bA:
48.6		 3glqA-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.35A 3glqA-5w4bA:
48.6		 3glqA-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.97A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.69A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.76A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
9W4  A 502 (-3.6A)
None
 0.44A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 1.02A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 1.11A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.37A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.75A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.93A 3glqB-5w4bA:
48.4		 3glqB-5w4bA:
56.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 11 GLY A 220
GLY A 222
GLU A 243
ILE A 244
ASP A 245
ILE A 281
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.3A)
NAD  A 501 (-2.8A)
NAD  A 501 (-4.2A)
None
NAD  A 501 (-4.8A)
 1.15A 3grvA-5w4bA:
4.0		 3grvA-5w4bA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLY A 220
GLY A 222
GLU A 243
ILE A 244
ASP A 245
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.3A)
NAD  A 501 (-2.8A)
NAD  A 501 (-4.2A)
None
 0.57A 3gryA-5w4bA:
4.3		 3gryA-5w4bA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 10 LEU A  54
HIS A  55
THR A  57
THR A  60
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
None
 0.32A 3h9uA-5w4bA:
46.2		 3h9uA-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 10 LEU A  54
THR A  60
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.71A 3h9uA-5w4bA:
46.2		 3h9uA-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 10 ASN A 346
LEU A 347
GLY A 352
HIS A 353
MET A 358
 NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.50A 3h9uB-5w4bA:
52.3		 3h9uB-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 10 HIS A  55
THR A  57
THR A  60
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
None
 0.24A 3h9uB-5w4bA:
52.3		 3h9uB-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 10 THR A  57
ASN A 346
LEU A 347
GLY A 352
HIS A 353
 9W4  A 502 (-2.9A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.83A 3h9uB-5w4bA:
52.3		 3h9uB-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 10 LEU A  54
HIS A  55
THR A  57
THR A  60
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
None
 0.28A 3h9uC-5w4bA:
52.3		 3h9uC-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 10 LEU A  54
THR A  60
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.71A 3h9uC-5w4bA:
52.3		 3h9uC-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 10 LEU A  54
HIS A  55
THR A  57
THR A  60
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
None
 0.28A 3h9uD-5w4bA:
52.3		 3h9uD-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 10 LEU A  54
THR A  60
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.72A 3h9uD-5w4bA:
52.3		 3h9uD-5w4bA:
72.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 3n58A-5w4bA:
48.4		 3n58A-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.69A 3n58A-5w4bA:
48.4		 3n58A-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 3n58A-5w4bA:
48.4		 3n58A-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.97A 3n58A-5w4bA:
48.4		 3n58A-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.28A 3n58A-5w4bA:
48.4		 3n58A-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 3n58C-5w4bA:
48.6		 3n58C-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.75A 3n58C-5w4bA:
48.6		 3n58C-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.45A 3n58C-5w4bA:
48.6		 3n58C-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 3n58C-5w4bA:
48.6		 3n58C-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.98A 3n58C-5w4bA:
48.6		 3n58C-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.31A 3n58C-5w4bA:
48.6		 3n58C-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
ASP A 190
LEU A 347
MET A 358
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 (-3.6A)
 1.13A 3n58C-5w4bA:
48.6		 3n58C-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.47A 3n58D-5w4bA:
48.7		 3n58D-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 3n58D-5w4bA:
48.7		 3n58D-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.72A 3n58D-5w4bA:
48.7		 3n58D-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.02A 3n58D-5w4bA:
48.7		 3n58D-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.30A 3n58D-5w4bA:
48.7		 3n58D-5w4bA:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
ASP A 190
LEU A 347
MET A 358
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 (-3.6A)
 1.15A 3n58D-5w4bA:
48.7		 3n58D-5w4bA:
59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 9 GLY A 220
ALA A 219
ILE A 282
ILE A 299
ILE A 281
 NAD  A 501 ( 3.7A)
None
None
NAD  A 501 (-4.3A)
NAD  A 501 (-4.8A)
 0.85A 3nu4B-5w4bA:
undetectable		 3nu4B-5w4bA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.00A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.74A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
None
9W4  A 502 (-3.6A)
None
 0.77A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
None
 0.81A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.48A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.96A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.96A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.73A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.71A 3ondA-5w4bA:
48.9		 3ondA-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.01A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.76A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
None
9W4  A 502 (-3.6A)
None
 0.76A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
None
 0.80A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.47A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.97A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.96A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.74A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.70A 3ondB-5w4bA:
45.9		 3ondB-5w4bA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 SER A 154
PRO A 176
TYR A 379
VAL A 175
 None
 1.05A 3sufC-5w4bA:
undetectable		 3sufC-5w4bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.05A 4coxA-5w4bA:
undetectable		 4coxA-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.04A 4coxB-5w4bA:
undetectable		 4coxB-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.04A 4coxD-5w4bA:
undetectable		 4coxD-5w4bA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.00A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.70A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
None
 0.85A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.63A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 1.04A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.98A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.73A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.60A 4lvcA-5w4bA:
48.1		 4lvcA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 4lvcB-5w4bA:
48.2		 4lvcB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.77A 4lvcB-5w4bA:
48.2		 4lvcB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.94A 4lvcB-5w4bA:
48.2		 4lvcB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 4lvcC-5w4bA:
48.3		 4lvcC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.61A 4lvcC-5w4bA:
48.3		 4lvcC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 4lvcC-5w4bA:
48.3		 4lvcC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 4lvcC-5w4bA:
48.3		 4lvcC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.90A 4lvcC-5w4bA:
48.3		 4lvcC-5w4bA:
57.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.09A 4otyB-5w4bA:
undetectable		 4otyB-5w4bA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 1.04A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.84A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.92A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.66A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
None
 0.84A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.66A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.94A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.65A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 7 GLU A  59
THR A  60
THR A 157
SER A 361
 9W4  A 502 (-3.8A)
None
None
None
 0.56A 4pfjA-5w4bA:
55.8		 4pfjA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 ASP A 131
LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.10A 4pfjB-5w4bA:
55.6		 4pfjB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.92A 4pfjB-5w4bA:
55.6		 4pfjB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.85A 4pfjB-5w4bA:
55.6		 4pfjB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.03A 4pfjB-5w4bA:
55.6		 4pfjB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.10A 4pfjB-5w4bA:
55.6		 4pfjB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 THR A  57
LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.50A 4pfjB-5w4bA:
55.6		 4pfjB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 6 GLU A  59
THR A  60
GLN A  85
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.76A 4pfjB-5w4bA:
55.6		 4pfjB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 ASP A 131
LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.00A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.87A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.44A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
ASN A 346
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.01A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
ASN A 346
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
NAD  A 501 (-3.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.06A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
ASN A 346
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-3.1A)
NAD  A 501 (-4.5A)
None
 1.47A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 6 THR A  57
GLU A  59
THR A  60
THR A 157
 9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
 0.62A 4pgfA-5w4bA:
55.9		 4pgfA-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 GLU A  59
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.92A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
GLU A  59
ASP A 131
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-3.8A)
None
None
9W4  A 502 (-3.6A)
None
 0.84A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
GLU A  59
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-3.8A)
None
None
9W4  A 502 (-3.6A)
None
 0.84A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.93A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.02A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.38A 4pgfB-5w4bA:
55.6		 4pgfB-5w4bA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.05A 4rrwC-5w4bA:
0.2		 4rrwC-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.04A 4rrwD-5w4bA:
undetectable		 4rrwD-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.11A 4rrxA-5w4bA:
undetectable		 4rrxA-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.12A 4rrxB-5w4bA:
undetectable		 4rrxB-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.05A 4rrzC-5w4bA:
0.2		 4rrzC-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.04A 4rrzD-5w4bA:
undetectable		 4rrzD-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		3 / 3 VAL A  74
ALA A  48
PHE A 120
 None
 0.90A 4z4iA-5w4bA:
2.0		 4z4iA-5w4bA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 7 ILE A 299
LEU A 199
GLY A 227
LYS A 226
 NAD  A 501 (-4.3A)
None
None
None
 1.03A 4z69A-5w4bA:
undetectable		 4z69A-5w4bA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.93A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.68A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.68A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.73A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.97A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.95A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.75A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.69A 5axaA-5w4bA:
55.4		 5axaA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.67A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.73A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.97A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
THR A  57
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.73A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.98A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.97A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.74A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.70A 5axaC-5w4bA:
55.4		 5axaC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.03A 5axdA-5w4bA:
55.4		 5axdA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLU A  59
ASP A 131
LYS A 186
HIS A 353
MET A 358
 9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.83A 5axdA-5w4bA:
55.4		 5axdA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
 0.77A 5axdA-5w4bA:
55.4		 5axdA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
GLU A  59
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
None
None
9W4  A 502 (-3.6A)
 0.74A 5axdA-5w4bA:
55.4		 5axdA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.46A 5axdA-5w4bA:
55.4		 5axdA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.94A 5axdA-5w4bA:
55.4		 5axdA-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.03A 5axdC-5w4bA:
55.4		 5axdC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLU A  59
ASP A 131
LYS A 186
HIS A 353
MET A 358
 9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.80A 5axdC-5w4bA:
55.4		 5axdC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
 0.77A 5axdC-5w4bA:
55.4		 5axdC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
GLU A  59
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
None
None
9W4  A 502 (-3.6A)
 0.73A 5axdC-5w4bA:
55.4		 5axdC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.47A 5axdC-5w4bA:
55.4		 5axdC-5w4bA:
96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.95A 5axdC-5w4bA:
55.4		 5axdC-5w4bA:
96.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 8 ALA A 393
HIS A 398
ARG A  38
THR A 185
 None
 1.18A 5db5A-5w4bA:
undetectable
5db5B-5w4bA:
undetectable		 5db5A-5w4bA:
21.13
5db5B-5w4bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLY A 220
ALA A 219
ILE A 282
ILE A 299
ILE A 281
 NAD  A 501 ( 3.7A)
None
None
NAD  A 501 (-4.3A)
NAD  A 501 (-4.8A)
 0.81A 5e5jA-5w4bA:
undetectable		 5e5jA-5w4bA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 5hm8A-5w4bA:
44.5		 5hm8A-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 5hm8A-5w4bA:
44.5		 5hm8A-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 5hm8A-5w4bA:
44.5		 5hm8A-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8A-5w4bA:
44.5		 5hm8A-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.77A 5hm8A-5w4bA:
44.5		 5hm8A-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.87A 5hm8B-5w4bA:
44.5		 5hm8B-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 5hm8B-5w4bA:
44.5		 5hm8B-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 5hm8B-5w4bA:
44.5		 5hm8B-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8B-5w4bA:
44.5		 5hm8B-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.77A 5hm8B-5w4bA:
44.5		 5hm8B-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.87A 5hm8C-5w4bA:
45.1		 5hm8C-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.69A 5hm8C-5w4bA:
45.1		 5hm8C-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 5hm8C-5w4bA:
45.1		 5hm8C-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8C-5w4bA:
45.1		 5hm8C-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.77A 5hm8C-5w4bA:
45.1		 5hm8C-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 5hm8D-5w4bA:
44.6		 5hm8D-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 5hm8D-5w4bA:
44.6		 5hm8D-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 5hm8D-5w4bA:
44.6		 5hm8D-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8D-5w4bA:
44.6		 5hm8D-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.77A 5hm8D-5w4bA:
44.6		 5hm8D-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.87A 5hm8E-5w4bA:
45.0		 5hm8E-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 5hm8E-5w4bA:
45.0		 5hm8E-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 5hm8E-5w4bA:
45.0		 5hm8E-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8E-5w4bA:
45.0		 5hm8E-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.77A 5hm8E-5w4bA:
45.0		 5hm8E-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.87A 5hm8F-5w4bA:
44.6		 5hm8F-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 5hm8F-5w4bA:
44.6		 5hm8F-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 5hm8F-5w4bA:
44.6		 5hm8F-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8F-5w4bA:
44.6		 5hm8F-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.77A 5hm8F-5w4bA:
44.6		 5hm8F-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 5hm8G-5w4bA:
44.5		 5hm8G-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 5hm8G-5w4bA:
44.5		 5hm8G-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 5hm8G-5w4bA:
44.5		 5hm8G-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8G-5w4bA:
44.5		 5hm8G-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.83A 5hm8G-5w4bA:
44.5		 5hm8G-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.87A 5hm8H-5w4bA:
45.0		 5hm8H-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.70A 5hm8H-5w4bA:
45.0		 5hm8H-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 5hm8H-5w4bA:
45.0		 5hm8H-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5hm8H-5w4bA:
45.0		 5hm8H-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 5 GLU A  59
THR A  60
GLU A 156
THR A 157
 9W4  A 502 (-3.8A)
None
None
None
 0.78A 5hm8H-5w4bA:
45.0		 5hm8H-5w4bA:
48.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ALA A 350
ILE A 114
TYR A 110
GLY A 133
THR A 159
 None
 1.21A 5jlcA-5w4bA:
undetectable		 5jlcA-5w4bA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		3 / 3 VAL A  74
ALA A  48
PHE A 120
 None
 0.87A 5js1A-5w4bA:
undetectable		 5js1A-5w4bA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.96A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.72A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.65A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.72A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.96A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.93A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.73A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.66A 5m5kA-5w4bA:
48.1		 5m5kA-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.38A 5m5kB-5w4bA:
48.2		 5m5kB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
None
9W4  A 502 (-3.6A)
None
 0.61A 5m5kB-5w4bA:
48.2		 5m5kB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.68A 5m5kB-5w4bA:
48.2		 5m5kB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 5m5kB-5w4bA:
48.2		 5m5kB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 THR A 157
LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.98A 5m5kB-5w4bA:
48.2		 5m5kB-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.77A 5m5kC-5w4bA:
47.9		 5m5kC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
THR A  57
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.92A 5m5kC-5w4bA:
47.9		 5m5kC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.92A 5m5kC-5w4bA:
47.9		 5m5kC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5m5kC-5w4bA:
47.9		 5m5kC-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.45A 5m66A-5w4bA:
48.0		 5m66A-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.93A 5m66A-5w4bA:
48.0		 5m66A-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.74A 5m66A-5w4bA:
48.0		 5m66A-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.93A 5m66A-5w4bA:
48.0		 5m66A-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.88A 5m66A-5w4bA:
48.0		 5m66A-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
ASP A 190
LEU A 347
MET A 358
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 (-3.6A)
 1.16A 5m66A-5w4bA:
48.0		 5m66A-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.95A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.67A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.68A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.77A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 1.00A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.95A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.75A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.66A 5m66B-5w4bA:
47.8		 5m66B-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.96A 5m66C-5w4bA:
47.9		 5m66C-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.77A 5m66C-5w4bA:
47.9		 5m66C-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.46A 5m66C-5w4bA:
47.9		 5m66C-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 5m66C-5w4bA:
47.9		 5m66C-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.91A 5m66C-5w4bA:
47.9		 5m66C-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
ASP A 190
LEU A 347
MET A 358
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 (-3.6A)
 1.18A 5m66C-5w4bA:
47.9		 5m66C-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.97A 5m66D-5w4bA:
48.1		 5m66D-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.71A 5m66D-5w4bA:
48.1		 5m66D-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.73A 5m66D-5w4bA:
48.1		 5m66D-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 5m66D-5w4bA:
48.1		 5m66D-5w4bA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.92A 5m66D-5w4bA:
48.1		 5m66D-5w4bA:
57.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 4 LEU A  63
MET A  29
ILE A  97
LEU A  22
 None
 1.40A 5nfpA-5w4bA:
undetectable		 5nfpA-5w4bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLY A 220
ALA A 219
ILE A 282
ILE A 299
ILE A 281
 NAD  A 501 ( 3.7A)
None
None
NAD  A 501 (-4.3A)
NAD  A 501 (-4.8A)
 0.78A 5t8hA-5w4bA:
undetectable		 5t8hA-5w4bA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.93A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.69A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
None
 0.73A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.53A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.94A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.88A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.70A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.64A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
ASP A 190
GLY A 352
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
None
 1.05A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
ASP A 190
LEU A 347
GLY A 352
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
 1.14A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
GLY A 352
MET A 358
PHE A 362
 None
None
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
None
 0.90A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A 157
LYS A 186
LEU A 347
GLY A 352
MET A 358
 None
None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
9W4  A 502 (-3.6A)
 1.05A 5utuF-5w4bA:
47.3		 5utuF-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.91A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
GLU A  59
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.73A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.70A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
9W4  A 502 (-3.6A)
None
 0.45A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.92A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.88A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.68A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.63A 5utuH-5w4bA:
45.4		 5utuH-5w4bA:
48.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 5v96A-5w4bA:
47.4		 5v96A-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.71A 5v96A-5w4bA:
47.4		 5v96A-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.74A 5v96A-5w4bA:
47.4		 5v96A-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.98A 5v96A-5w4bA:
47.4		 5v96A-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.92A 5v96A-5w4bA:
47.4		 5v96A-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.96A 5v96B-5w4bA:
47.8		 5v96B-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.86A 5v96B-5w4bA:
47.8		 5v96B-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.98A 5v96B-5w4bA:
47.8		 5v96B-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.94A 5v96B-5w4bA:
47.8		 5v96B-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.98A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.74A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.70A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.75A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.99A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.95A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.76A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.69A 5v96C-5w4bA:
47.6		 5v96C-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.00A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LEU A  54
ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.74A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.71A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.78A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 1.01A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.95A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.78A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.68A 5v96D-5w4bA:
47.7		 5v96D-5w4bA:
56.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 6aphA-5w4bA:
52.6		 6aphA-5w4bA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.79A 6aphA-5w4bA:
52.6		 6aphA-5w4bA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.91A 6aphA-5w4bA:
52.6		 6aphA-5w4bA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.14A 6aphA-5w4bA:
52.6		 6aphA-5w4bA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.35A 6aphA-5w4bA:
52.6		 6aphA-5w4bA:
68.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		4 / 8 LEU A 338
VAL A 296
THR A 274
ASP A 307
 None
 0.92A 6cp4A-5w4bA:
undetectable		 6cp4A-5w4bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		3 / 3 GLN A 251
TYR A 221
ASN A 248
 None
None
NAD  A 501 (-3.2A)
 1.05A 6dwdC-5w4bA:
undetectable		 6dwdC-5w4bA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLU A 105
LEU A 344
SER A  78
LEU A 347
GLN A 324
 None
NAD  A 501 (-4.0A)
None
9W4  A 502 (-4.1A)
9W4  A 502 (-4.2A)
 1.15A 6ew0F-5w4bA:
6.1		 6ew0F-5w4bA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 GLU A 105
LEU A 344
SER A  78
LEU A 347
GLN A 324
 None
NAD  A 501 (-4.0A)
None
9W4  A 502 (-4.1A)
9W4  A 502 (-4.2A)
 1.15A 6ew0G-5w4bA:
6.1		 6ew0G-5w4bA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASN A 346
LEU A 347
GLY A 352
HIS A 353
MET A 358
 NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.48A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 190
ASN A 346
LEU A 347
GLY A 352
HIS A 353
 NAD  A 501 (-4.1A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.44A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  57
THR A  60
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
None
 0.60A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  57
THR A  60
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
None
 0.23A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A  57
ASN A 346
LEU A 347
GLY A 352
HIS A 353
 9W4  A 502 (-2.9A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.79A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 10 GLY A 220
GLY A 222
GLU A 243
ASP A 245
THR A 276
ILE A 281
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.3A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-3.8A)
NAD  A 501 (-4.8A)
 0.19A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		3 / 3 LEU A 409
GLN A 413
LYS A 426
 None
 0.24A 6exiB-5w4bA:
47.5		 6exiB-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
THR A  60
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 1.16A 6exiB-5w4bA:
47.5		 6exiB-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
ASN A 346
LEU A 344
HIS A 353
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.1A)
NAD  A 501 (-4.0A)
NAD  A 501 (-4.5A)
 1.35A 6exiB-5w4bA:
47.5		 6exiB-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
ASN A 346
LEU A 347
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.12A 6exiB-5w4bA:
47.5		 6exiB-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 THR A  60
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.32A 6exiB-5w4bA:
47.5		 6exiB-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		3 / 3 LEU A 409
GLN A 413
LYS A 426
 None
 0.22A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 10 GLY A 220
GLY A 222
GLU A 243
ASP A 245
THR A 276
ILE A 281
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.3A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-3.8A)
NAD  A 501 (-4.8A)
 0.18A 6exiB-5w4bA:
47.5		 6exiB-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A  54
HIS A  55
THR A  57
THR A  60
ASP A 190
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
 0.55A 6exiC-5w4bA:
48.4		 6exiC-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LEU A  54
HIS A  55
THR A  57
THR A  60
MET A 358
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
 0.17A 6exiC-5w4bA:
48.4		 6exiC-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 GLY A 220
GLY A 222
GLU A 243
ASP A 245
THR A 276
ILE A 281
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.3A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-3.8A)
NAD  A 501 (-4.8A)
 0.19A 6exiC-5w4bA:
48.4
6exiD-5w4bA:
49.1		 6exiC-5w4bA:
12.89
6exiD-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASN A 346
LEU A 347
GLY A 352
HIS A 353
MET A 358
 NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.48A 6exiD-5w4bA:
49.1		 6exiD-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 190
ASN A 346
LEU A 347
GLY A 352
HIS A 353
 NAD  A 501 (-4.1A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.49A 6exiD-5w4bA:
49.1		 6exiD-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  57
THR A  60
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
None
 0.62A 6exiD-5w4bA:
49.1		 6exiD-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  57
THR A  60
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
None
 0.23A 6exiD-5w4bA:
49.1		 6exiD-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 THR A  57
ASN A 346
LEU A 347
GLY A 352
HIS A 353
 9W4  A 502 (-2.9A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.82A 6exiD-5w4bA:
49.1		 6exiD-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 GLY A 220
GLY A 222
GLU A 243
ASP A 245
THR A 276
ILE A 281
 NAD  A 501 ( 3.7A)
NAD  A 501 (-3.3A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-3.8A)
NAD  A 501 (-4.8A)
 0.18A 6exiC-5w4bA:
48.4
6exiD-5w4bA:
49.1		 6exiC-5w4bA:
12.89
6exiD-5w4bA:
12.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.01A 6f3mA-5w4bA:
47.1		 6f3mA-5w4bA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.72A 6f3mA-5w4bA:
47.1		 6f3mA-5w4bA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.80A 6f3mA-5w4bA:
47.1		 6f3mA-5w4bA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 6f3mA-5w4bA:
47.1		 6f3mA-5w4bA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.07A 6f3mA-5w4bA:
47.1		 6f3mA-5w4bA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.29A 6f3mA-5w4bA:
47.1		 6f3mA-5w4bA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.00A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.79A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.73A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.82A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.92A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.91A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.73A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.68A 6f3mB-5w4bA:
47.2		 6f3mB-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.01A 6f3mC-5w4bA:
46.9		 6f3mC-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.73A 6f3mC-5w4bA:
46.9		 6f3mC-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.81A 6f3mC-5w4bA:
46.9		 6f3mC-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 6f3mC-5w4bA:
46.9		 6f3mC-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.07A 6f3mC-5w4bA:
46.9		 6f3mC-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.29A 6f3mC-5w4bA:
46.9		 6f3mC-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.00A 6f3mD-5w4bA:
47.0		 6f3mD-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.72A 6f3mD-5w4bA:
47.0		 6f3mD-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.80A 6f3mD-5w4bA:
47.0		 6f3mD-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.95A 6f3mD-5w4bA:
47.0		 6f3mD-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.91A 6f3mD-5w4bA:
47.0		 6f3mD-5w4bA:
58.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.99A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.76A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.70A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.81A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.92A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 1.03A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.28A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.71A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.91A 6f3nA-5w4bA:
47.2		 6f3nA-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.98A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.76A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		8 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
None
9W4  A 502 (-3.6A)
None
 0.73A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
None
 0.80A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
 9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
 1.44A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.91A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.91A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.71A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.68A 6f3nB-5w4bA:
47.1		 6f3nB-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.98A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.76A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.70A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.80A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.91A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.95A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.28A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.70A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.82A 6f3nC-5w4bA:
47.2		 6f3nC-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
ASP A 190
HIS A 353
PHE A 362
 None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
None
 0.99A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 ASP A 131
LYS A 186
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.76A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
9W4  A 502 (-3.6A)
None
 0.70A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 HIS A  55
THR A  57
ASP A 131
LYS A 186
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
NAD  A 501 (-4.1A)
None
 0.80A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
GLY A 352
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
None
 0.92A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
GLY A 352
HIS A 353
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 1.02A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.28A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.70A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
LEU A 344
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.90A 6f3nD-5w4bA:
47.2		 6f3nD-5w4bA:
56.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 ASP A 131
LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.00A 6gbnA-5w4bA:
52.9		 6gbnA-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.88A 6gbnA-5w4bA:
52.9		 6gbnA-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.78A 6gbnA-5w4bA:
52.9		 6gbnA-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.90A 6gbnA-5w4bA:
52.9		 6gbnA-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 ASP A 131
LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 1.02A 6gbnB-5w4bA:
52.3		 6gbnB-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.90A 6gbnB-5w4bA:
52.3		 6gbnB-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.79A 6gbnB-5w4bA:
52.3		 6gbnB-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.01A 6gbnB-5w4bA:
52.3		 6gbnB-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.39A 6gbnB-5w4bA:
52.3		 6gbnB-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 6gbnC-5w4bA:
52.9		 6gbnC-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.78A 6gbnC-5w4bA:
52.9		 6gbnC-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 344
LEU A 347
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.0A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 1.01A 6gbnC-5w4bA:
52.9		 6gbnC-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		5 / 12 LYS A 186
ASP A 190
LEU A 347
HIS A 353
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
NAD  A 501 (-4.5A)
None
 1.39A 6gbnC-5w4bA:
52.9		 6gbnC-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 ASP A 131
LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.99A 6gbnD-5w4bA:
52.7		 6gbnD-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		7 / 12 LEU A  54
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.86A 6gbnD-5w4bA:
52.7		 6gbnD-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		9 / 12 LEU A  54
HIS A  55
THR A  57
ASP A 131
GLU A 156
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.78A 6gbnD-5w4bA:
52.7		 6gbnD-5w4bA:
65.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens) 		6 / 12 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.90A 6gbnD-5w4bA:
52.7		 6gbnD-5w4bA:
65.15