SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5w4m TRANSCRIPTIONAL
REGULATOR
(Streptococcus
dysgalactiae) 		5 / 10 ILE A 145
GLY A 149
LEU A 187
GLN A 139
LEU A 160
 None
 1.03A 5fhzC-5w4mA:
undetectable		 5fhzC-5w4mA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5w4m TRANSCRIPTIONAL
REGULATOR
(Streptococcus
dysgalactiae) 		3 / 3 THR A  65
THR A   8
ARG A  11
 None
 1.04A 5wm2A-5w4mA:
undetectable		 5wm2A-5w4mA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5w4m TRANSCRIPTIONAL
REGULATOR
(Streptococcus
dysgalactiae) 		5 / 12 ILE A 211
ASN A 190
TYR A 266
HIS A 231
LEU A 207
 None
None
DMS  A 305 (-3.6A)
None
None
 1.18A 6chgC-5w4mA:
undetectable		 6chgC-5w4mA:
20.44