SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5w4t CADHERIN 23
(Danio
rerio) 		3 / 3 ASP C 237
ARG C 244
ASP C 208
 CA  C 407 (-2.7A)
None
None
 0.64A 1vptA-5w4tC:
undetectable		 1vptA-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 9 ILE C 233
GLY C 266
GLY C 247
ARG C 234
ILE C 246
 None
 1.18A 2y7wA-5w4tC:
undetectable		 2y7wA-5w4tC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 9 ALA C 182
VAL C 180
VAL C 142
GLY C 157
ALA C 131
 None
 0.95A 2z0yA-5w4tC:
undetectable		 2z0yA-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 9 ALA C 182
VAL C 180
VAL C 142
GLY C 157
ALA C 131
 None
 0.81A 2z0yB-5w4tC:
undetectable		 2z0yB-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 5w4t CADHERIN 23
(Danio
rerio) 		4 / 5 ASP C 135
ASP C  99
TYR C  18
GLU C  71
 CA  C 403 ( 3.1A)
CA  C 403 (-3.0A)
None
CA  C 403 ( 2.4A)
 1.45A 3l2wA-5w4tC:
undetectable		 3l2wA-5w4tC:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5w4t CADHERIN 23
(Danio
rerio) 		4 / 5 ASP C 135
ASP C 133
ASP C 184
ARG C 189
 CA  C 403 ( 3.1A)
CA  C 404 (-2.2A)
CA  C 404 (-3.2A)
None
 1.48A 3naiC-5w4tC:
undetectable		 3naiC-5w4tC:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5w4t CADHERIN 23
(Danio
rerio) 		4 / 5 ASP C 135
ASP C 184
ASP C 186
ARG C 189
 CA  C 403 ( 3.1A)
CA  C 404 (-3.2A)
None
None
 1.15A 3naiC-5w4tC:
undetectable		 3naiC-5w4tC:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 12 VAL C  62
PHE C  53
THR C  21
LEU C  68
ILE C  27
 None
 1.10A 3qfxA-5w4tC:
undetectable		 3qfxA-5w4tC:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 12 VAL C  62
PHE C  53
THR C  21
LEU C  68
ILE C  27
 None
 1.10A 3qfxB-5w4tC:
undetectable		 3qfxB-5w4tC:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 10 PHE C  11
SER C  13
LEU C  15
PHE C  80
VAL C  93
 None
 1.31A 3u9fI-5w4tC:
undetectable		 3u9fI-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 12 PHE C  11
SER C  13
LEU C  15
PHE C  80
VAL C  93
 None
 1.39A 3u9fJ-5w4tC:
undetectable
3u9fK-5w4tC:
undetectable		 3u9fJ-5w4tC:
undetectable
3u9fK-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 10 PHE C  11
SER C  13
LEU C  15
PHE C  80
VAL C  93
 None
 1.31A 3u9fR-5w4tC:
undetectable		 3u9fR-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5w4t CADHERIN 23
(Danio
rerio) 		3 / 3 ASP C 237
ARG C 244
ASP C 208
 CA  C 407 (-2.7A)
None
None
 0.62A 4fp9D-5w4tC:
undetectable		 4fp9D-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5w4t CADHERIN 23
(Danio
rerio) 		3 / 3 ASP C 237
ARG C 244
ASP C 208
 CA  C 407 (-2.7A)
None
None
 0.61A 4fzvA-5w4tC:
undetectable		 4fzvA-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 12 TYR C  14
ASN C  94
GLY C  98
GLY C 137
SER C  74
 None
 1.22A 4obwC-5w4tC:
undetectable		 4obwC-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5w4t CADHERIN 23
(Danio
rerio) 		4 / 4 ASN C   8
VAL C  93
THR C  28
ILE C  27
 None
 1.06A 4retA-5w4tC:
undetectable		 4retA-5w4tC:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5w4t CADHERIN 23
(Danio
rerio) 		4 / 4 ASN C   8
VAL C  93
THR C  28
ILE C  27
 None
 1.05A 4retC-5w4tC:
undetectable		 4retC-5w4tC:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 9 VAL C  93
ASN C   8
LEU C  15
GLN C  31
VAL C  62
 None
None
None
MPD  C 408 ( 4.9A)
None
 1.13A 6czmA-5w4tC:
undetectable
6czmB-5w4tC:
undetectable		 6czmA-5w4tC:
undetectable
6czmB-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5w4t CADHERIN 23
(Danio
rerio) 		5 / 9 VAL C  93
ASN C   8
LEU C  15
GLN C  31
VAL C  62
 None
None
None
MPD  C 408 ( 4.9A)
None
 1.22A 6czmB-5w4tC:
undetectable
6czmC-5w4tC:
undetectable		 6czmB-5w4tC:
undetectable
6czmC-5w4tC:
undetectable