SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 244
GLY C 247
MET C  37
LEU C  33
VAL C   8
 None
 1.27A 1a27A-5w4uC:
undetectable		 1a27A-5w4uC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 6 HIS C 131
LEU C  44
LEU C  72
PRO C  71
 None
 1.23A 1hz4A-5w4uC:
undetectable		 1hz4A-5w4uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 8 ILE C  63
ARG C  66
PRO C 132
VAL C 142
 None
 0.99A 4f4dB-5w4uC:
undetectable		 4f4dB-5w4uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 6 ASN C 206
GLU C 177
TYR C 180
GLU C 179
 None
 1.28A 4mi4A-5w4uC:
undetectable		 4mi4A-5w4uC:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 12 ASP C 117
LEU C 118
LEU C  67
LEU C 153
ILE C 144
 None
 1.03A 4x1fA-5w4uC:
undetectable		 4x1fA-5w4uC:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 12 ASP C 117
LEU C 118
LEU C  67
LEU C 153
ILE C 144
 None
 1.07A 4x1gA-5w4uC:
undetectable		 4x1gA-5w4uC:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 5 HIS C 131
ASN C 123
VAL C 121
LEU C  99
 None
 1.47A 5xdhD-5w4uC:
undetectable		 5xdhD-5w4uC:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		3 / 3 TRP C 170
ILE C  46
ASP C  47
 None
 0.55A 6i0y7-5w4uC:
undetectable		 6i0y7-5w4uC:
undetectable