SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ALA A 137
VAL A 134
TRP A 214
 None
 0.70A 1bdwA-5w4xA:
undetectable
1bdwB-5w4xA:
undetectable		 1bdwA-5w4xA:
4.18
1bdwB-5w4xA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 4 ARG A 102
ALA A 103
ALA A 290
GLU A 289
 None
 1.04A 1e7bA-5w4xA:
undetectable		 1e7bA-5w4xA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 4 ARG A 102
ALA A 103
ALA A 290
GLU A 289
 None
 1.08A 1e7bB-5w4xA:
undetectable		 1e7bB-5w4xA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 5 ARG A 102
ALA A 103
ALA A 290
GLU A 289
 None
 1.05A 1e7cA-5w4xA:
undetectable		 1e7cA-5w4xA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A 269
VAL A 270
GLY A 271
GLY A 441
PHE A 314
 None
 1.23A 1fduC-5w4xA:
7.9		 1fduC-5w4xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 11 SER A 269
VAL A 270
GLY A 271
GLY A 441
PHE A 314
 None
 1.40A 1iolA-5w4xA:
6.1		 1iolA-5w4xA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 8 LEU A 423
VAL A 411
TYR A 367
TYR A 425
 None
 0.85A 1jlfA-5w4xA:
undetectable
1jlfB-5w4xA:
undetectable		 1jlfA-5w4xA:
22.89
1jlfB-5w4xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 7 ILE A  52
PRO A  18
GLU A  54
ALA A 168
 None
 1.12A 1oniG-5w4xA:
undetectable
1oniI-5w4xA:
undetectable		 1oniG-5w4xA:
14.77
1oniI-5w4xA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 10 SER A 316
PHE A 314
ILE A 353
LEU A 357
ASP A 359
 None
 1.42A 3m0wC-5w4xA:
undetectable
3m0wD-5w4xA:
undetectable
3m0wE-5w4xA:
undetectable
3m0wF-5w4xA:
undetectable		 3m0wC-5w4xA:
12.33
3m0wD-5w4xA:
12.33
3m0wE-5w4xA:
12.33
3m0wF-5w4xA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_G_P77G203_1
(PROTEIN S100-A4)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 9 SER A 316
PHE A 314
ILE A 353
LEU A 357
ASP A 359
 None
 1.46A 3m0wG-5w4xA:
undetectable
3m0wH-5w4xA:
undetectable
3m0wI-5w4xA:
undetectable
3m0wJ-5w4xA:
undetectable		 3m0wG-5w4xA:
12.33
3m0wH-5w4xA:
12.33
3m0wI-5w4xA:
12.33
3m0wJ-5w4xA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 10 LEU A 357
ASP A 359
SER A 316
PHE A 314
ILE A 353
 None
 1.41A 3m0wE-5w4xA:
undetectable
3m0wF-5w4xA:
undetectable
3m0wG-5w4xA:
undetectable
3m0wH-5w4xA:
undetectable		 3m0wE-5w4xA:
12.33
3m0wF-5w4xA:
12.33
3m0wG-5w4xA:
12.33
3m0wH-5w4xA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 10 LEU A 357
ASP A 359
SER A 316
PHE A 314
ILE A 353
 None
 1.43A 3m0wA-5w4xA:
undetectable
3m0wB-5w4xA:
undetectable
3m0wI-5w4xA:
undetectable
3m0wJ-5w4xA:
undetectable		 3m0wA-5w4xA:
12.33
3m0wB-5w4xA:
12.33
3m0wI-5w4xA:
12.33
3m0wJ-5w4xA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 428
TYR A 425
ALA A 332
ILE A 376
GLY A 335
 None
 1.13A 3ozwB-5w4xA:
2.9		 3ozwB-5w4xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A 349
TYR A 352
ASP A 379
GLN A 375
GLY A 273
 None
None
None
None
PG5  A 501 (-4.2A)
 1.33A 4iilA-5w4xA:
undetectable		 4iilA-5w4xA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A 127
LEU A 195
VAL A 198
VAL A  32
 None
 1.01A 4l4bA-5w4xA:
undetectable		 4l4bA-5w4xA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 10 TYR A 199
LEU A 172
LEU A  69
ALA A  24
GLY A  17
 None
 1.49A 4rn6A-5w4xA:
undetectable		 4rn6A-5w4xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 6 GLY A  16
THR A  19
SER A  88
VAL A  15
 None
 1.10A 5ewuA-5w4xA:
2.9		 5ewuA-5w4xA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LYS A 170
ASP A 171
ASN A 224
LYS A 339
PHE A 338
 None
None
PG5  A 501 (-4.1A)
PG5  A 501 ( 4.3A)
None
 1.35A 5kc0A-5w4xA:
undetectable		 5kc0A-5w4xA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLN A 278
ALA A 228
GLN A 229
SER A 232
 None
 1.08A 5km8A-5w4xA:
undetectable
5km8B-5w4xA:
undetectable		 5km8A-5w4xA:
16.20
5km8B-5w4xA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 PHE A 314
ILE A 318
ALA A 408
VAL A 411
ILE A 331
 None
 1.27A 5mlmA-5w4xA:
4.9		 5mlmA-5w4xA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 163
VAL A  15
GLY A  17
SER A  21
VAL A 178
 None
 1.44A 6a94A-5w4xA:
undetectable		 6a94A-5w4xA:
22.43