SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 7 PHE A 248
SER A 232
SER A  22
PHE A  14
 9WY  A 501 (-3.4A)
9WY  A 501 (-3.6A)
RBF  A 502 (-3.8A)
RBF  A 502 (-3.6A)
 1.14A 1fxvA-5w4zA:
undetectable
1fxvB-5w4zA:
undetectable		 1fxvA-5w4zA:
undetectable
1fxvB-5w4zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 9 PHE A 284
ILE A 380
ASP A 390
LEU A 389
GLY A 391
 None
 1.25A 1i00A-5w4zA:
undetectable		 1i00A-5w4zA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 9 PHE A 284
ILE A 380
ASP A 390
LEU A 389
GLY A 391
 None
 1.23A 1i00B-5w4zA:
undetectable		 1i00B-5w4zA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 10 MET A 107
LEU A  60
GLU A 114
MET A 123
ALA A  17
 None
 1.28A 1wrkA-5w4zA:
undetectable
1wrkB-5w4zA:
undetectable		 1wrkA-5w4zA:
20.88
1wrkB-5w4zA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 6 ALA A 345
HIS A 158
ASP A 159
TYR A 162
 None
9WY  A 501 (-3.8A)
None
None
 0.84A 2dpzA-5w4zA:
undetectable		 2dpzA-5w4zA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		3 / 3 ASN A 137
TYR A 162
SER A 110
 None
 0.80A 2gvcB-5w4zA:
undetectable		 2gvcB-5w4zA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		3 / 3 ASN A 137
TYR A 162
SER A 110
 None
 0.80A 2gvcE-5w4zA:
undetectable		 2gvcE-5w4zA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 6 THR A  19
ARG A  34
THR A 143
ASP A  68
 None
 1.26A 2okcB-5w4zA:
undetectable		 2okcB-5w4zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 7 LEU A 414
PHE A 406
ILE A 380
PHE A 392
 None
 0.96A 2opxA-5w4zA:
undetectable		 2opxA-5w4zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 12 ALA A  25
VAL A 310
TRP A 359
GLY A 363
GLY A  23
 None
 1.00A 2p16A-5w4zA:
undetectable		 2p16A-5w4zA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 5 GLN A 343
THR A 342
ARG A 346
ALA A 345
 RBF  A 502 (-4.1A)
9WY  A 501 (-3.7A)
None
None
 1.28A 2qhfA-5w4zA:
undetectable		 2qhfA-5w4zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 12 GLY A 132
VAL A 172
GLY A 223
SER A 220
ALA A 120
 None
 1.08A 3keeC-5w4zA:
undetectable		 3keeC-5w4zA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 12 GLY A 244
GLY A 231
GLY A 236
SER A 340
ALA A 230
 None
9WY  A 501 (-3.3A)
9WY  A 501 ( 4.5A)
RBF  A 502 (-3.1A)
9WY  A 501 (-3.4A)
 1.06A 3kkzB-5w4zA:
undetectable		 3kkzB-5w4zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 7 GLU A 375
VAL A 369
VAL A 410
ALA A 377
 None
 1.01A 3kp6B-5w4zA:
undetectable		 3kp6B-5w4zA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 11 ALA A 165
ASP A 166
ASP A 163
GLY A 236
THR A 141
 None
None
None
9WY  A 501 ( 4.5A)
9WY  A 501 (-4.5A)
 1.14A 3spkA-5w4zA:
undetectable		 3spkA-5w4zA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 6 PHE A  14
ASN A  16
ALA A  63
THR A 143
 RBF  A 502 (-3.6A)
RBF  A 502 (-3.8A)
RBF  A 502 ( 3.8A)
None
 1.05A 3t3sB-5w4zA:
undetectable		 3t3sB-5w4zA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 8 PHE A  14
ASN A  16
ALA A  63
THR A 143
 RBF  A 502 (-3.6A)
RBF  A 502 (-3.8A)
RBF  A 502 ( 3.8A)
None
 1.09A 3t3sE-5w4zA:
undetectable		 3t3sE-5w4zA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 10 PHE A 284
ILE A 380
ASP A 390
LEU A 389
GLY A 391
 None
 1.24A 4eb4D-5w4zA:
undetectable		 4eb4D-5w4zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		4 / 5 ILE A 404
PRO A 400
HIS A  35
VAL A 302
 None
 1.16A 4s0vA-5w4zA:
undetectable		 4s0vA-5w4zA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 10 PRO A 182
VAL A 440
LEU A 441
ARG A 442
ALA A 448
 None
 1.08A 5o96E-5w4zA:
3.8
5o96F-5w4zA:
3.6		 5o96E-5w4zA:
undetectable
5o96F-5w4zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5w4z RIBOFLAVIN LYASE
(Herbiconiux) 		5 / 12 LEU A 393
VAL A 106
ASN A 137
SER A 232
THR A 342
 None
None
None
9WY  A 501 (-3.6A)
9WY  A 501 (-3.7A)
 1.39A 5v1tA-5w4zA:
5.3		 5v1tA-5w4zA:
undetectable