SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 12 HIS A 138
HIS A  61
GLU A 253
ASP A 279
ASP A  59
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
None
ZN  A 401 (-2.3A)
None
 1.32A 1a4lA-5w57A:
undetectable		 1a4lA-5w57A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 12 HIS A  61
GLY A 223
GLU A 253
ASP A 279
ASP A  59
 ZN  A 401 (-3.2A)
None
None
ZN  A 401 (-2.3A)
None
 1.30A 1a4lD-5w57A:
undetectable		 1a4lD-5w57A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		4 / 5 THR A 226
ASP A 279
HIS A 138
HIS A 204
 None
ZN  A 401 (-2.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
 1.17A 1ei6A-5w57A:
undetectable		 1ei6A-5w57A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 10 THR A  60
LEU A  90
PHE A  89
THR A  81
GLY A  83
 None
 1.19A 1h4oA-5w57A:
undetectable
1h4oB-5w57A:
undetectable		 1h4oA-5w57A:
20.83
1h4oB-5w57A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 11 VAL A  30
THR A  99
ILE A  94
THR A  81
LEU A  90
 None
 1.36A 3bexC-5w57A:
undetectable
3bexD-5w57A:
undetectable		 3bexC-5w57A:
22.26
3bexD-5w57A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 11 THR A  81
LEU A  90
VAL A  30
THR A  99
ILE A  94
 None
 1.35A 3bexE-5w57A:
undetectable
3bexF-5w57A:
undetectable		 3bexE-5w57A:
22.26
3bexF-5w57A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 11 VAL A  30
THR A  99
ILE A  94
THR A  81
LEU A  90
 None
 1.39A 3bf1A-5w57A:
undetectable
3bf1B-5w57A:
undetectable		 3bf1A-5w57A:
22.26
3bf1B-5w57A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 11 THR A  81
LEU A  90
VAL A  30
THR A  99
ILE A  94
 None
 1.34A 3bf1C-5w57A:
undetectable
3bf1D-5w57A:
undetectable		 3bf1C-5w57A:
22.26
3bf1D-5w57A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 11 VAL A  30
THR A  99
ILE A  94
THR A  81
LEU A  90
 None
 1.37A 3bf1E-5w57A:
undetectable
3bf1F-5w57A:
undetectable		 3bf1E-5w57A:
22.26
3bf1F-5w57A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 11 THR A  81
LEU A  90
VAL A  30
THR A  99
ILE A  94
 None
 1.34A 3bf1E-5w57A:
undetectable
3bf1F-5w57A:
undetectable		 3bf1E-5w57A:
22.26
3bf1F-5w57A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		3 / 3 PRO A 271
PHE A 251
ALA A 305
 None
 0.51A 3itaD-5w57A:
undetectable		 3itaD-5w57A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		4 / 6 PHE A 210
ILE A 302
ALA A 299
ALA A 188
 None
 0.97A 3mdrB-5w57A:
undetectable		 3mdrB-5w57A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		4 / 7 TYR A 149
LEU A  50
LEU A 106
PHE A  33
 None
 1.21A 3nk2X-5w57A:
undetectable		 3nk2X-5w57A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		3 / 3 HIS A 138
HIS A  61
HIS A 204
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.55A 3qpkA-5w57A:
undetectable		 3qpkA-5w57A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		3 / 3 HIS A 138
HIS A  61
HIS A 204
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.56A 3qpkB-5w57A:
undetectable		 3qpkB-5w57A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 10 PHE A 210
VAL A 216
PHE A 218
ALA A 303
PHE A 251
 None
 1.18A 3t3qD-5w57A:
undetectable		 3t3qD-5w57A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 10 ILE A  36
VAL A  52
PHE A  33
ILE A 255
ILE A  35
 None
 1.28A 3um5A-5w57A:
undetectable		 3um5A-5w57A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 10 ILE A  36
VAL A  52
PHE A  33
ILE A 255
ILE A  35
 None
 1.29A 3um5B-5w57A:
undetectable		 3um5B-5w57A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		5 / 9 LEU A 272
ALA A 268
VAL A 201
LEU A 219
ILE A 250
 None
 1.31A 3wsjA-5w57A:
undetectable		 3wsjA-5w57A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		4 / 8 ALA A 280
SER A 278
HIS A 138
HIS A  61
 None
None
ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
 1.11A 5km8A-5w57A:
undetectable
5km8B-5w57A:
undetectable		 5km8A-5w57A:
19.29
5km8B-5w57A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		3 / 3 HIS A 138
HIS A  61
HIS A 204
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.53A 5migA-5w57A:
undetectable		 5migA-5w57A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 5w57 PERIPLASMIC SOLUTE
BINDING PROTEIN
(Paracoccus
denitrificans) 		4 / 5 HIS A 204
HIS A 138
PHE A  86
HIS A  61
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.2A)
 1.10A 5zrdB-5w57A:
undetectable		 5zrdB-5w57A:
19.49