SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR
(Mycobacterium
tuberculosis) 		5 / 11 ARG A  35
THR A 199
ALA A  34
ALA A  30
VAL A  27
 None
 1.11A 2qhfA-5w5bA:
undetectable		 2qhfA-5w5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 101
LEU A 102
VAL A  81
GLY A  84
 None
 0.71A 2wd9A-5w5bA:
undetectable		 2wd9A-5w5bA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 101
LEU A 102
VAL A  81
GLY A  84
 None
 0.71A 2wd9B-5w5bA:
undetectable		 2wd9B-5w5bA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 106
GLY A  38
PRO A 104
ARG A  47
 None
 1.04A 3s3mA-5w5bA:
undetectable		 3s3mA-5w5bA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 108
GLY A  38
VAL A  37
ASP A 106
 None
 1.09A 3vqrA-5w5bA:
undetectable		 3vqrA-5w5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 108
GLY A  38
VAL A  37
ASP A 106
 None
 1.07A 3vqrB-5w5bA:
undetectable		 3vqrB-5w5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  82
VAL A  50
LEU A  53
SER A  51
 None
 1.24A 4e1gA-5w5bA:
0.1		 4e1gA-5w5bA:
7.72