SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		5 / 12 ALA O 426
SER O 429
ILE O 423
SER O 437
PHE O 489
 None
 1.10A 1ve3B-5w5yO:
undetectable		 1ve3B-5w5yO:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		4 / 4 ILE O 203
ARG O 273
ILE O 216
THR O 220
 None
 1.29A 3ia4C-5w5yO:
undetectable		 3ia4C-5w5yO:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		4 / 6 GLY O 262
ILE O 263
GLN O 270
VAL O 286
 None
 1.06A 4d39B-5w5yO:
undetectable		 4d39B-5w5yO:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		4 / 8 ASP O 183
ASP O 409
ASP O 410
GLU O 509
 None
 0.99A 4feuD-5w5yO:
undetectable		 4feuD-5w5yO:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		4 / 6 GLN O 454
ILE O 511
PHE O 537
PHE O 467
 None
 1.27A 4fgkA-5w5yO:
undetectable		 4fgkA-5w5yO:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		4 / 6 GLY O 262
ILE O 263
GLN O 270
VAL O 286
 None
 1.08A 4kcnA-5w5yO:
undetectable		 4kcnA-5w5yO:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		4 / 5 LEU O 357
ASP O 376
TRP O 360
ILE O 402
 None
 1.38A 4mwrA-5w5yO:
5.1		 4mwrA-5w5yO:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		5 / 12 PRO O 330
GLY O 327
ILE O 318
ARG O 339
LEU O 312
 None
 1.02A 5fa8A-5w5yO:
undetectable		 5fa8A-5w5yO:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		3 / 3 ARG O 273
THR O 189
ASP O 192
 None
 0.96A 5g5gA-5w5yO:
undetectable
5g5gB-5w5yO:
undetectable		 5g5gA-5w5yO:
14.67
5g5gB-5w5yO:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		3 / 3 TYR O 686
ASP O 688
GLN O 689
 None
 0.86A 6g1pA-5w5yO:
undetectable		 6g1pA-5w5yO:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		4 / 5 GLY O 262
LEU O 260
SER O 289
GLN O 270
 None
 1.22A 6ji6A-5w5yO:
undetectable		 6ji6A-5w5yO:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		5 / 12 ASP O 409
VAL O 424
ILE O 414
TYR O 405
TYR O 469
 None
 1.17A 6mkeA-5w5yO:
undetectable
6mkeD-5w5yO:
undetectable		 6mkeA-5w5yO:
6.04
6mkeD-5w5yO:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6
(Saccharomyces
cerevisiae) 		5 / 12 ASP O 409
VAL O 424
ILE O 414
TYR O 405
TYR O 469
 None
 1.17A 6mkeB-5w5yO:
undetectable
6mkeC-5w5yO:
undetectable		 6mkeB-5w5yO:
6.04
6mkeC-5w5yO:
6.04