SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5w5z 3C10 FAB LIGHT CHAIN
(Rattus
norvegicus) 		4 / 5 LEU L 178
GLY L 127
PRO L 119
VAL L 131
 None
 0.90A 2aojA-5w5zL:
undetectable		 2aojA-5w5zL:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5w5z 3C10 FAB LIGHT CHAIN
(Rattus
norvegicus) 		4 / 8 TYR L 172
GLU L 104
PHE L  10
VAL L 162
 None
 1.17A 2fl5E-5w5zL:
16.4
2fl5F-5w5zL:
12.3		 2fl5E-5w5zL:
18.88
2fl5F-5w5zL:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5w5z 3C10 FAB LIGHT CHAIN
(Rattus
norvegicus) 		5 / 12 GLN L   6
HIS L  91
LEU L  73
PRO L  55
ILE L  48
 None
 1.49A 4kmuH-5w5zL:
undetectable		 4kmuH-5w5zL:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5w5z 3C10 FAB LIGHT CHAIN
(Rattus
norvegicus) 		4 / 5 LEU L 178
ASP L 150
GLU L 153
VAL L 205
 None
 1.24A 4nkvA-5w5zL:
undetectable		 4nkvA-5w5zL:
11.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5w5z 3C10 FAB LIGHT CHAIN
(Rattus
norvegicus) 		4 / 7 TYR L  32
TYR L  36
TYR L  49
PRO L  55
 None
 0.62A 5aclA-5w5zL:
18.3		 5aclA-5w5zL:
39.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5w5z 3C10 FAB LIGHT CHAIN
(Rattus
norvegicus) 		4 / 6 GLU L 184
ARG L 187
ASP L 156
ASP L 150
 None
 1.18A 5zw4A-5w5zL:
undetectable		 5zw4A-5w5zL:
undetectable