SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 PHE A 176
ILE A 198
LYS A  85
ALA A  89
 None
 1.17A 1hk2A-5w6mA:
undetectable		 1hk2A-5w6mA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
GLN A 173
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 None
 1.07A 1httB-5w6mA:
31.2		 1httB-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 None
 0.91A 1httB-5w6mA:
31.2		 1httB-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 132
TYR A 330
GLY A 360
TYR A 363
GLY A 381
 None
 1.02A 1httC-5w6mA:
31.8		 1httC-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 None
 0.76A 1httC-5w6mA:
31.8		 1httC-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 132
TYR A 330
TYR A 331
GLY A 360
GLY A 381
 None
 0.95A 1httD-5w6mA:
31.4		 1httD-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A 466
ILE A 465
ALA A 414
LEU A 427
ILE A 498
 None
 1.18A 1xzxX-5w6mA:
undetectable		 1xzxX-5w6mA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A  80
ALA A 338
VAL A 209
PHE A  84
HIS A  87
 None
 1.40A 2qo4A-5w6mA:
0.4		 2qo4A-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ALA A 179
ILE A 178
ARG A 362
PRO A 187
 None
 0.98A 3fxrA-5w6mA:
undetectable		 3fxrA-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ARG A 149
TYR A 363
LEU A 366
TYR A 129
 None
 1.20A 4f8yC-5w6mA:
undetectable
4f8yD-5w6mA:
undetectable		 4f8yC-5w6mA:
16.41
4f8yD-5w6mA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 441
THR A 409
ALA A 458
ILE A 460
 None
 0.79A 4ubsA-5w6mA:
undetectable		 4ubsA-5w6mA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 SER A 323
LEU A 324
ASP A 239
LYS A 243
 None
 1.01A 4umjA-5w6mA:
undetectable		 4umjA-5w6mA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 380
VAL A 334
GLY A 333
ARG A 362
 None
 1.03A 5d4nA-5w6mA:
undetectable
5d4nC-5w6mA:
undetectable		 5d4nA-5w6mA:
undetectable
5d4nC-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLN A 173
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 None
 0.87A 5e3iA-5w6mA:
29.8		 5e3iA-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 132
TYR A 330
TYR A 331
GLY A 360
TYR A 363
 None
 1.05A 5e3iA-5w6mA:
29.8		 5e3iA-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 None
 0.67A 5e3iA-5w6mA:
29.8		 5e3iA-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 GLN A 173
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 None
 0.88A 5e3iB-5w6mA:
29.5		 5e3iB-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ARG A 149
ARG A 137
THR A  94
ILE A  92
 None
 1.43A 5ih0A-5w6mA:
undetectable		 5ih0A-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 VAL A 249
LEU A 322
SER A 323
ILE A 216
 None
 0.84A 5jw1A-5w6mA:
undetectable		 5jw1A-5w6mA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A  77
ILE A  80
ALA A 359
SER A 356
ILE A 384
 None
 1.36A 5mlmA-5w6mA:
undetectable		 5mlmA-5w6mA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ASP A 488
VAL A 489
GLU A 470
ALA A 416
 None
 1.23A 6djzB-5w6mA:
undetectable		 6djzB-5w6mA:
undetectable