SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
THR A 155
LEU A 251
GLY A 249
 None
 0.94A 1gtiB-5w6tA:
undetectable		 1gtiB-5w6tA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 5 TRP A  84
PRO A  58
LEU A  54
GLY A 303
 None
 1.25A 1ya4C-5w6tA:
undetectable		 1ya4C-5w6tA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 SER A 125
TRP A 127
ASP A 241
ILE A 243
 None
 1.46A 2oxtD-5w6tA:
undetectable		 2oxtD-5w6tA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ASP A  45
ASN A 296
THR A 301
 None
 0.71A 2pymB-5w6tA:
undetectable		 2pymB-5w6tA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 GLY A  72
ASN A 150
PHE A 118
ARG A 149
 None
 1.32A 3ccfA-5w6tA:
undetectable		 3ccfA-5w6tA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ASN A 129
ASN A 131
GLU A 156
 None
 0.85A 3kpdC-5w6tA:
undetectable		 3kpdC-5w6tA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.89A 4eq4A-5w6tA:
undetectable		 4eq4A-5w6tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.90A 4eqlA-5w6tA:
undetectable		 4eqlA-5w6tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.90A 4eqlB-5w6tA:
undetectable		 4eqlB-5w6tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLY A 286
GLY A  49
VAL A 300
GLN A 295
ILE A 297
 None
 1.22A 4fglA-5w6tA:
undetectable
4fglB-5w6tA:
undetectable		 4fglA-5w6tA:
22.69
4fglB-5w6tA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 PHE A 102
LEU A 177
LEU A 179
TYR A 105
LEU A  61
 None
 1.25A 4j03A-5w6tA:
undetectable		 4j03A-5w6tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.91A 4l39A-5w6tA:
undetectable		 4l39A-5w6tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.91A 4l39B-5w6tA:
undetectable		 4l39B-5w6tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 LEU A 177
TYR A 148
PRO A 254
ILE A 123
 None
 1.31A 5esgA-5w6tA:
undetectable		 5esgA-5w6tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLY A 100
PHE A 102
GLY A 228
GLY A 181
LEU A 194
 None
 1.12A 5gwxA-5w6tA:
undetectable		 5gwxA-5w6tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 5w6t HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 TRP A 153
HIS A 130
ASN A 131
GLU A 158
 None
 1.35A 6gneA-5w6tA:
undetectable		 6gneA-5w6tA:
19.53