SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 CYH A 174
SER A  79
LEU A  80
ALA A  83
LEU A  84
 None
 0.81A 1hwkB-5w70A:
undetectable		 1hwkB-5w70A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 CYH A 174
SER A  79
LEU A  80
ALA A  83
LEU A  84
 None
 0.81A 1hwkA-5w70A:
undetectable		 1hwkA-5w70A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 CYH A 174
SER A  79
LEU A  80
ALA A  83
LEU A  84
 None
 0.82A 1hwkD-5w70A:
undetectable		 1hwkD-5w70A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 CYH A 174
SER A  79
LEU A  80
ALA A  83
LEU A  84
 None
 0.82A 1hwkC-5w70A:
undetectable		 1hwkC-5w70A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 10 ASP A 173
ALA A 175
GLY A 209
GLY A 210
THR A 108
 9YM  A 501 (-2.9A)
9YM  A 501 (-3.4A)
None
None
None
 1.01A 1k6cA-5w70A:
undetectable		 1k6cA-5w70A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 12 SER A 206
MET A 198
GLU A  54
SER A  52
PHE A  57
 None
 1.47A 1s2aA-5w70A:
undetectable		 1s2aA-5w70A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 GLY A 207
SER A 206
LEU A 266
HIS A 178
HIS A 395
 None
 1.45A 2a58A-5w70A:
2.2
2a58E-5w70A:
undetectable		 2a58A-5w70A:
17.08
2a58E-5w70A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 HIS A 395
GLY A 207
SER A 206
LEU A 266
HIS A 178
 None
 1.46A 2a58C-5w70A:
2.0
2a58D-5w70A:
2.0		 2a58C-5w70A:
17.08
2a58D-5w70A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 12 PHE A  57
TYR A  53
SER A 259
ALA A 211
GLY A 209
 None
 1.11A 2igtA-5w70A:
undetectable		 2igtA-5w70A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 12 PHE A  57
TYR A  53
SER A 259
ALA A 211
GLY A 209
 None
 1.11A 2igtB-5w70A:
2.6		 2igtB-5w70A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 12 PHE A  57
TYR A  53
SER A 259
ALA A 211
GLY A 209
 None
 1.12A 2igtC-5w70A:
2.9		 2igtC-5w70A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 5 LEU A 354
VAL A 330
LEU A 334
ARG A 316
 None
 0.85A 2oiqA-5w70A:
undetectable		 2oiqA-5w70A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 9 PHE A 219
ALA A 220
VAL A 223
GLU A 224
 None
 0.57A 2vufA-5w70A:
undetectable		 2vufA-5w70A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 12 GLY A 111
VAL A 103
GLY A  90
ALA A 114
ALA A 143
 None
 1.06A 3sugA-5w70A:
undetectable		 3sugA-5w70A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		3 / 3 ARG A  40
ARG A  48
ILE A  43
 None
 0.89A 4b7qC-5w70A:
undetectable		 4b7qC-5w70A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 8 THR A 195
ALA A 193
THR A 214
VAL A 212
 None
 0.80A 4ik7B-5w70A:
undetectable		 4ik7B-5w70A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 7 ARG A 360
SER A 197
VAL A 103
TRP A 102
 None
9YM  A 501 (-2.5A)
None
9YM  A 501 (-3.6A)
 1.49A 4klaA-5w70A:
undetectable		 4klaA-5w70A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 MET A 198
ALA A  78
LEU A  82
ILE A 213
GLY A 194
 None
 1.21A 4pxmB-5w70A:
undetectable		 4pxmB-5w70A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		3 / 3 GLU A 224
THR A 248
HIS A 225
 None
 0.75A 4q15A-5w70A:
undetectable		 4q15A-5w70A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 6 LEU A 398
LEU A 393
ILE A 408
MET A 405
 None
 0.83A 4ww7A-5w70A:
undetectable		 4ww7A-5w70A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		3 / 3 GLU A 224
THR A 248
HIS A 225
 None
 0.73A 4ydqB-5w70A:
undetectable		 4ydqB-5w70A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 7 ALA A 193
ARG A 221
THR A 248
GLU A 250
 None
 0.84A 5bs8A-5w70A:
0.8
5bs8B-5w70A:
undetectable
5bs8C-5w70A:
0.8		 5bs8A-5w70A:
23.70
5bs8B-5w70A:
20.76
5bs8C-5w70A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 7 ALA A 193
ARG A 221
THR A 248
GLU A 250
 None
 0.82A 5btdA-5w70A:
0.8
5btdB-5w70A:
undetectable
5btdC-5w70A:
1.0		 5btdA-5w70A:
23.70
5btdB-5w70A:
20.76
5btdC-5w70A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 6 ALA A 193
ARG A 221
THR A 248
GLU A 250
 None
 0.85A 5btgA-5w70A:
0.8
5btgB-5w70A:
undetectable
5btgC-5w70A:
0.8		 5btgA-5w70A:
23.70
5btgB-5w70A:
20.76
5btgC-5w70A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 6 GLU A 172
GLY A  90
ARG A 142
GLY A  88
 None
 0.95A 5cdnC-5w70A:
undetectable
5cdnD-5w70A:
undetectable		 5cdnC-5w70A:
22.93
5cdnD-5w70A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 6 GLU A 172
GLY A  90
ARG A 142
GLY A  88
 None
 0.94A 5cdnT-5w70A:
undetectable
5cdnU-5w70A:
undetectable		 5cdnT-5w70A:
22.93
5cdnU-5w70A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		3 / 3 ASP A 288
SER A 151
TYR A 310
 None
 0.75A 5glmA-5w70A:
undetectable		 5glmA-5w70A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 12 ILE A 349
ASP A 120
LEU A 380
PHE A 118
ALA A 386
 None
 1.15A 5x5qB-5w70A:
undetectable		 5x5qB-5w70A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		5 / 11 VAL A 121
TYR A 150
LEU A 149
THR A 390
ALA A 386
 None
 1.41A 6dk1C-5w70A:
undetectable		 6dk1C-5w70A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE
(Streptomyces
ribosidificus) 		4 / 8 TYR A  64
ASN A  65
PHE A  61
VAL A 203
 None
 1.24A 6huoC-5w70A:
undetectable
6huoD-5w70A:
undetectable		 6huoC-5w70A:
11.03
6huoD-5w70A:
11.19