SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.05A 1e7bA-5w75A:
0.9		 1e7bA-5w75A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.03A 1e7bB-5w75A:
undetectable		 1e7bB-5w75A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 5 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.08A 1e7cA-5w75A:
undetectable		 1e7cA-5w75A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 9 LEU A 157
VAL A 168
TYR A 163
GLY A 165
LEU A 104
 None
 1.19A 1ikvA-5w75A:
undetectable		 1ikvA-5w75A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 10 LEU A 157
VAL A 168
TYR A 163
GLY A 165
LEU A 104
 None
 1.16A 1ikwA-5w75A:
undetectable		 1ikwA-5w75A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 12 GLY A 173
VAL A 141
ALA A 185
PHE A 134
LEU A 192
 None
 1.32A 1nw3A-5w75A:
undetectable		 1nw3A-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 8 ILE A  32
LEU A 192
MET A 131
GLY A 101
 None
 1.07A 1os6A-5w75A:
undetectable		 1os6A-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 7 ASP A  87
GLY A  16
ILE A 103
THR A 116
 None
 0.73A 1t7jB-5w75A:
undetectable		 1t7jB-5w75A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 4 LEU A 157
PRO A 129
ILE A  18
LEU A 104
 None
 1.08A 1ya4B-5w75A:
undetectable		 1ya4B-5w75A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 4 LEU A 157
PRO A 129
ILE A  18
LEU A 104
 None
 1.10A 1ya4C-5w75A:
undetectable		 1ya4C-5w75A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 11 HIS A 119
THR A 116
ARG A 117
HIS A  85
LEU A 104
 None
 1.32A 2a5hA-5w75A:
2.7		 2a5hA-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 12 HIS A 119
THR A 116
ARG A 117
HIS A  85
LEU A 104
 None
 1.32A 2a5hC-5w75A:
2.8		 2a5hC-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 12 HIS A 119
THR A 116
ARG A 117
HIS A  85
LEU A 104
 None
 1.31A 2a5hD-5w75A:
2.7		 2a5hD-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 12 GLY A  16
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 0.80A 2oz7A-5w75A:
undetectable		 2oz7A-5w75A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 12 LEU A 157
VAL A 168
TYR A 163
GLY A 165
LEU A 104
 None
 1.04A 3medA-5w75A:
undetectable
3medB-5w75A:
undetectable		 3medA-5w75A:
undetectable
3medB-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 12 THR A 254
LEU A 278
GLY A 276
MET A 213
PHE A 211
 None
 1.39A 3n58C-5w75A:
2.5		 3n58C-5w75A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 7 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.87A 4eq4A-5w75A:
1.5		 4eq4A-5w75A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 8 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.85A 4eq4B-5w75A:
1.8		 4eq4B-5w75A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 7 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.89A 4eqlA-5w75A:
1.3		 4eqlA-5w75A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 7 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.88A 4eqlB-5w75A:
1.4		 4eqlB-5w75A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 7 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.94A 4l39B-5w75A:
0.7		 4l39B-5w75A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 6 ALA A  30
ASP A  81
LEU A 179
SER A 174
 None
MG  A 402 ( 4.0A)
None
GDP  A 401 (-3.0A)
 1.11A 4ot2A-5w75A:
undetectable		 4ot2A-5w75A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 5 ALA A 294
ARG A 234
ALA A 368
GLU A 370
 None
 1.21A 5a06C-5w75A:
2.4
5a06D-5w75A:
2.4		 5a06C-5w75A:
undetectable
5a06D-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		5 / 12 ILE A  93
ALA A 376
PHE A 331
ILE A  61
LEU A 312
 None
 1.11A 6dwnD-5w75A:
undetectable		 6dwnD-5w75A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5w75 ELONGATION FACTOR TU
(Thermotoga
neapolitana) 		4 / 7 ILE A 215
GLN A 291
GLU A 286
VAL A 228
 None
 1.19A 6j20A-5w75A:
undetectable		 6j20A-5w75A:
undetectable