SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.99A 1e7bA-5w76A:
1.6		 1e7bA-5w76A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.99A 1e7bB-5w76A:
undetectable		 1e7bB-5w76A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 5 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 1.06A 1e7cA-5w76A:
undetectable		 1e7cA-5w76A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 7 ASP A  87
GLY A  16
ILE A 103
THR A 116
 None
 0.68A 1t7jB-5w76A:
undetectable		 1t7jB-5w76A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 11 SER A 160
GLY A 165
GLU A 156
ILE A 168
ARG A 117
 None
 1.41A 1vhwC-5w76A:
4.9
1vhwE-5w76A:
4.8		 1vhwC-5w76A:
16.21
1vhwE-5w76A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 11 ARG A 117
SER A 160
GLY A 165
GLU A 156
ILE A 168
 None
 1.43A 1vhwA-5w76A:
4.9
1vhwD-5w76A:
4.8		 1vhwA-5w76A:
16.21
1vhwD-5w76A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 5 ALA A  37
ALA A  42
GLN A  49
VAL A  68
 None
 0.77A 2nyrB-5w76A:
3.5		 2nyrB-5w76A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 GLY A  16
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 0.75A 2oz7A-5w76A:
undetectable		 2oz7A-5w76A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 VAL A 105
ILE A 168
ILE A 200
PRO A 201
ILE A 103
 None
 1.19A 3clbD-5w76A:
undetectable		 3clbD-5w76A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 VAL A 105
ILE A 168
ILE A 200
PRO A 201
ILE A 103
 None
 1.21A 3hbbD-5w76A:
undetectable		 3hbbD-5w76A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 PHE A 305
GLY A 340
PHE A 323
VAL A 309
PHE A 375
 None
 1.47A 3r6wA-5w76A:
4.1
3r6wB-5w76A:
6.4		 3r6wA-5w76A:
15.20
3r6wB-5w76A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 PHE A 323
VAL A 309
PHE A 375
PHE A 305
GLY A 340
 None
 1.42A 3r6wA-5w76A:
4.1
3r6wB-5w76A:
6.4		 3r6wA-5w76A:
15.20
3r6wB-5w76A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 ASP A 355
VAL A 384
ILE A 377
ILE A 359
PHE A 323
 None
 1.41A 4dz3A-5w76A:
undetectable		 4dz3A-5w76A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 ASP A 355
VAL A 384
ILE A 377
ILE A 359
PHE A 323
 None
 1.41A 4dz3B-5w76A:
undetectable		 4dz3B-5w76A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 7 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.93A 4eq4A-5w76A:
undetectable		 4eq4A-5w76A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 8 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.92A 4eq4B-5w76A:
1.5		 4eq4B-5w76A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 7 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.94A 4eqlA-5w76A:
1.5		 4eqlA-5w76A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 7 THR A  94
ILE A  61
THR A 383
GLY A 385
 None
 0.95A 4eqlB-5w76A:
1.4		 4eqlB-5w76A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		3 / 3 ARG A 124
TYR A  88
ASN A 356
 None
 0.90A 4ffwB-5w76A:
3.5		 4ffwB-5w76A:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 9 TYR A  70
LEU A  28
VAL A 105
VAL A 196
LEU A 192
 None
 1.22A 4g1bC-5w76A:
3.4		 4g1bC-5w76A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 ALA A  96
GLY A  95
GLY A  16
ASN A  91
GLU A  56
 None
 1.28A 4jlgA-5w76A:
undetectable		 4jlgA-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 9 PHE A 375
GLY A 318
GLY A 385
LEU A 312
GLU A 316
 None
 1.22A 4l8wI-5w76A:
3.7		 4l8wI-5w76A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 5 GLY A  84
ASP A  87
GLU A 118
VAL A 126
 None
 0.98A 4nkvD-5w76A:
undetectable		 4nkvD-5w76A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 9 ALA A 123
GLY A  16
ALA A 102
ILE A 120
VAL A 105
 None
 1.07A 4r21B-5w76A:
undetectable		 4r21B-5w76A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 LEU A 122
LEU A 158
VAL A 133
VAL A 128
PHE A 163
 None
 1.16A 4wnwA-5w76A:
undetectable		 4wnwA-5w76A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 5 ALA A 294
ARG A 234
ALA A 368
GLU A 370
 None
 1.25A 5a06C-5w76A:
3.4
5a06D-5w76A:
2.9		 5a06C-5w76A:
undetectable
5a06D-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		4 / 5 ALA A 123
HIS A 119
MET A  92
LEU A 104
 None
 1.49A 5dzkf-5w76A:
undetectable
5dzkt-5w76A:
undetectable		 5dzkf-5w76A:
undetectable
5dzkt-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		3 / 3 SER A  64
LEU A 122
MET A  92
 None
 0.76A 5ikrB-5w76A:
undetectable		 5ikrB-5w76A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 ASP A 139
ALA A 188
THR A  33
GLY A  24
LEU A  28
 GDP  A 404 (-2.3A)
None
None
GDP  A 404 (-3.1A)
None
 1.18A 5m54E-5w76A:
5.1		 5m54E-5w76A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.21A 5n0rA-5w76A:
undetectable		 5n0rA-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.21A 5n0xB-5w76A:
undetectable		 5n0xB-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 10 MET A 190
ILE A 189
ASP A 194
THR A  72
THR A  17
 PGE  A 403 (-3.8A)
None
None
None
None
 1.41A 6b4yA-5w76A:
2.3		 6b4yA-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5w76 ANCESTRAL ELOGATION
FACTOR N153
(synthetic
construct) 		5 / 12 GLY A 340
ARG A  59
ARG A 378
ALA A 376
ALA A 386
 None
 1.05A 6c2mD-5w76A:
2.6		 6c2mD-5w76A:
22.62