SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 10 ALA B 488
LEU B 415
LEU B 501
ILE B 364
HIS B 412
 None
 1.40A 1a52B-5w7aB:
undetectable		 1a52B-5w7aB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 9 ALA B 488
LEU B 415
LEU B 501
ILE B 364
HIS B 412
 None
 1.44A 1ereD-5w7aB:
undetectable		 1ereD-5w7aB:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 GLN B 572
TYR B 319
ARG B 321
 None
 0.93A 1gtbA-5w7aB:
undetectable		 1gtbA-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 7 LEU B 480
THR B 483
LEU B 415
GLY B 417
 None
P6G  B 608 (-3.3A)
None
None
 0.93A 1gtiB-5w7aB:
undetectable		 1gtiB-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 8 ASP B 296
ASN B 335
ILE B 336
GLY B 340
 None
None
None
FTT  B 609 ( 3.3A)
 0.88A 1meiA-5w7aB:
undetectable		 1meiA-5w7aB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 6 TYR B 333
TYR B 319
HIS B 330
PRO B 193
 None
 1.31A 1q13A-5w7aB:
undetectable		 1q13A-5w7aB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 VAL B 291
ALA B 290
HIS B 268
 None
 0.66A 1q23G-5w7aB:
undetectable		 1q23G-5w7aB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 VAL B 291
ALA B 290
HIS B 268
 None
 0.60A 1q23J-5w7aB:
undetectable		 1q23J-5w7aB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 SER B 411
GLY B 410
ARG B 217
 None
 0.64A 1t9wA-5w7aB:
undetectable		 1t9wA-5w7aB:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 7 ALA B 265
SER B 301
ASP B 296
ASN B 335
 None
 0.74A 1yc5A-5w7aB:
undetectable		 1yc5A-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 11 ILE B 256
ILE B 364
TYR B 416
GLY B 264
LEU B 543
 None
 1.17A 2azyA-5w7aB:
undetectable		 2azyA-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 GLY B 197
TYR B 198
SER B 190
 None
 0.70A 2xatA-5w7aB:
undetectable		 2xatA-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 ARG B 201
GLY B 202
SER B 317
 None
 0.36A 2xctB-5w7aB:
undetectable		 2xctB-5w7aB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 10 THR B 304
SER B 301
ALA B 265
GLY B 264
ARG B 196
 None
 1.47A 2xfsA-5w7aB:
undetectable		 2xfsA-5w7aB:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 11 THR B 304
SER B 301
ALA B 265
GLY B 264
ARG B 196
 None
 1.48A 2xfsB-5w7aB:
undetectable		 2xfsB-5w7aB:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 5 ASN B 532
ALA B 540
LEU B 258
GLY B 264
 None
 0.83A 3dl9A-5w7aB:
undetectable		 3dl9A-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 12 GLY B 452
LEU B 447
ASP B 527
SER B 464
GLY B 461
 None
FTT  B 609 (-4.3A)
FTT  B 609 ( 4.8A)
None
None
 0.83A 3g2oB-5w7aB:
2.2		 3g2oB-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 VAL B 442
VAL A  44
SER A  48
 None
 0.66A 3n8xB-5w7aB:
undetectable		 3n8xB-5w7aB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 12 GLY B 215
SER B 354
GLY B 202
LEU B 359
ASN B 356
 None
 1.48A 3r24A-5w7aB:
undetectable		 3r24A-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 8 HIS B 530
ASP B 296
GLU B 272
TRP B 273
 FTT  B 609 (-3.8A)
None
None
None
 0.89A 3sg9B-5w7aB:
undetectable		 3sg9B-5w7aB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		5 / 9 ALA B 341
ILE B 366
ASP B 261
GLY B 264
ALA B 265
 None
 1.09A 4r1zA-5w7aB:
undetectable		 4r1zA-5w7aB:
10.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
(Oryctolagus
cuniculus) 		4 / 4 TYR A  38
GLY B 340
ASN B 372
ARG B 378
 None
FTT  B 609 ( 3.3A)
FTT  B 609 (-3.1A)
PO4  B 607 (-3.3A)
 0.33A 5w7bA-5w7aA:
12.0
5w7bC-5w7aA:
undetectable		 5w7bA-5w7aA:
100.00
5w7bC-5w7aA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 GLY B 340
ASN B 372
ARG B 378
 FTT  B 609 ( 3.3A)
FTT  B 609 (-3.1A)
PO4  B 607 (-3.3A)
 0.17A 5w7bD-5w7aB:
65.6		 5w7bD-5w7aB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 ASN B 329
PRO B 253
GLN B 252
 None
 0.82A 6jnhA-5w7aB:
undetectable		 6jnhA-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT
(Oryctolagus
cuniculus) 		3 / 3 ASN B 329
PRO B 253
GLN B 252
 None
 0.85A 6jogA-5w7aB:
undetectable		 6jogA-5w7aB:
undetectable