SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		3 / 3 GLN C 572
TYR C 320
ARG C 322
 None
 0.93A 1gtbA-5w7cC:
undetectable		 1gtbA-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 7 LEU C 480
THR C 483
LEU C 415
GLY C 417
 None
 0.93A 1gtiB-5w7cC:
undetectable		 1gtiB-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 8 ASP C 297
ASN C 336
ILE C 337
GLY C 341
 None
None
None
FTT  C 610 ( 3.1A)
 0.87A 1meiA-5w7cC:
undetectable		 1meiA-5w7cC:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 6 TYR C 334
TYR C 320
HIS C 331
PRO C 194
 None
 1.28A 1q13A-5w7cC:
undetectable		 1q13A-5w7cC:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 PRO C 408
GLY C 556
ASN C 330
ILE C 258
LEU C 354
 None
 1.22A 1r30A-5w7cC:
undetectable		 1r30A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 PRO C 408
GLY C 556
ASN C 330
ILE C 258
LEU C 354
 None
 1.21A 1r30B-5w7cC:
undetectable		 1r30B-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5w7c ACYLOXYACYL
HYDROLASE
ACYLOXYACYL
HYDROLASE
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU C 288
LEU A  73
ILE C 270
THR A  82
VAL A  50
 None
None
FTT  C 611 (-3.9A)
None
FTT  C 611 ( 4.3A)
 1.22A 2qd3A-5w7cC:
2.5		 2qd3A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		3 / 3 GLY C 198
TYR C 199
SER C 191
 None
 0.76A 2xatA-5w7cC:
undetectable		 2xatA-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		3 / 3 ARG C 202
GLY C 203
SER C 318
 None
 0.38A 2xctB-5w7cC:
undetectable		 2xctB-5w7cC:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 5 VAL C 180
GLN C 335
PHE C 193
ARG C 356
 None
 1.29A 3bjwE-5w7cC:
undetectable		 3bjwE-5w7cC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 5 ASN C 532
ALA C 540
LEU C 259
GLY C 265
 None
 0.87A 3dl9A-5w7cC:
undetectable		 3dl9A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 8 HIS C 530
ASP C 297
GLU C 273
TRP C 274
 DAO  C 609 ( 3.3A)
None
None
FTT  C 611 (-4.9A)
 0.93A 3sg9B-5w7cC:
undetectable		 3sg9B-5w7cC:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5w7c ACYLOXYACYL
HYDROLASE
ACYLOXYACYL
HYDROLASE
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU C 288
LEU A  73
ILE C 270
THR A  82
VAL A  50
 None
None
FTT  C 611 (-3.9A)
None
FTT  C 611 ( 4.3A)
 1.21A 4f4dA-5w7cC:
3.0		 4f4dA-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 8 LEU A 111
VAL A 107
VAL A  62
ILE A  51
 None
 0.96A 4l4cB-5w7cA:
undetectable		 4l4cB-5w7cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 11 LEU C 484
SER C 344
LEU C 347
ASP C 374
LEU C 480
 None
 1.44A 4or0A-5w7cC:
undetectable		 4or0A-5w7cC:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 SER C 310
GLY C 303
GLY C 306
ASN C 336
LEU C 536
 None
 1.20A 5kocB-5w7cC:
2.0		 5kocB-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 10 GLY C 528
MET C 463
TYR C 448
PHE C 505
PHE C 423
 None
None
None
DAO  C 609 ( 4.9A)
DAO  C 609 ( 3.8A)
 1.24A 5lbtA-5w7cC:
3.3
5lbtB-5w7cC:
3.5		 5lbtA-5w7cC:
16.91
5lbtB-5w7cC:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 8 PHE C 499
GLN C 553
ILE C 554
GLY C 556
 None
 0.97A 5nzxA-5w7cC:
undetectable		 5nzxA-5w7cC:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 7 THR C 290
LYS C 189
GLN C 178
GLU C 177
 None
 1.10A 5tudA-5w7cC:
undetectable		 5tudA-5w7cC:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 288
LEU A  73
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 1.06A 6b0iB-5w7cA:
undetectable		 6b0iB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 292
LEU A  79
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 0.92A 6b0iB-5w7cA:
undetectable		 6b0iB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 288
LEU A  73
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 1.07A 6b0lB-5w7cA:
undetectable		 6b0lB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A  86
LEU C 292
LEU A  79
GLY A  43
LEU A  46
 None
None
None
FTT  A 202 ( 3.2A)
FTT  C 611 ( 4.5A)
 0.82A 6b0lB-5w7cA:
undetectable		 6b0lB-5w7cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		3 / 3 ASN C 330
PRO C 254
GLN C 253
 None
 0.89A 6jnhA-5w7cC:
undetectable		 6jnhA-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		3 / 3 ASN C 330
PRO C 254
GLN C 253
 None
 0.91A 6jogA-5w7cC:
undetectable		 6jogA-5w7cC:
undetectable