SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 7 LEU A 479
THR A 482
LEU A 414
GLY A 416
 None
 0.94A 1gtiB-5w7dA:
undetectable		 1gtiB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 12 HIS A 552
ILE A 546
ILE A 413
ARG A 254
ALA A 363
 None
 1.21A 1ki7B-5w7dA:
undetectable		 1ki7B-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 6 TYR A 333
TYR A 319
HIS A 330
PRO A 193
 None
 1.33A 1q13A-5w7dA:
undetectable		 1q13A-5w7dA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 12 PRO A 407
GLY A 555
ASN A 329
ILE A 257
LEU A 353
 None
 1.21A 1r30A-5w7dA:
undetectable		 1r30A-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 12 PRO A 407
GLY A 555
ASN A 329
ILE A 257
LEU A 353
 None
 1.21A 1r30B-5w7dA:
undetectable		 1r30B-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 8 PHE A 267
ASN A 296
SER A 174
ALA A 265
 PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
 1.01A 1rqpC-5w7dA:
undetectable		 1rqpC-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 8 PHE A 267
ASN A 296
SER A 174
ALA A 265
 PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
 1.01A 1rqpA-5w7dA:
undetectable		 1rqpA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 12 ALA A 368
ILE A 370
VAL A 303
LEU A 536
GLN A 538
 None
 1.31A 1udtA-5w7dA:
undetectable		 1udtA-5w7dA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 5 PHE A 446
LEU A  41
PHE A 447
SER A 377
 PX8  A 610 ( 4.2A)
PX8  A 610 ( 4.5A)
None
None
 1.33A 1wrkB-5w7dA:
undetectable		 1wrkB-5w7dA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 7 PHE A 528
PHE A 446
LEU A  41
SER A 377
 PX8  A 610 (-4.9A)
PX8  A 610 ( 4.2A)
PX8  A 610 ( 4.5A)
None
 1.15A 1wrlE-5w7dA:
undetectable		 1wrlE-5w7dA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 11 HIS A 529
HIS A 266
ALA A 265
SER A 335
GLY A 260
 PX8  A 610 (-3.7A)
None
None
None
None
 1.24A 2uxpB-5w7dA:
2.2		 2uxpB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 8 PHE A 267
ASN A 296
SER A 174
ALA A 265
 PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
 0.98A 2v7uA-5w7dA:
undetectable		 2v7uA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		3 / 3 GLY A 197
TYR A 198
SER A 190
 None
 0.72A 2xatA-5w7dA:
undetectable		 2xatA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		3 / 3 ARG A 201
GLY A 202
SER A 317
 None
 0.42A 2xctB-5w7dA:
undetectable		 2xctB-5w7dA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 5 ASN A 531
ALA A 539
LEU A 258
GLY A 264
 None
 0.87A 3dl9A-5w7dA:
undetectable		 3dl9A-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 9 GLY A 260
ALA A 263
GLY A 264
MET A 369
HIS A 529
 None
None
None
None
PX8  A 610 (-3.7A)
 1.16A 4c5lB-5w7dA:
undetectable		 4c5lB-5w7dA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 8 LEU A 110
VAL A 106
VAL A  61
ILE A  50
 None
 0.99A 4l4cB-5w7dA:
undetectable		 4l4cB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 7 GLN A 390
LEU A 479
THR A 482
THR A 470
 None
 0.87A 4mbsA-5w7dA:
undetectable		 4mbsA-5w7dA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 12 GLY A 260
LEU A 346
ARG A 201
MET A 369
VAL A 395
 None
 1.42A 4okxA-5w7dA:
undetectable		 4okxA-5w7dA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 11 LEU A 483
SER A 343
LEU A 346
ASP A 373
LEU A 479
 None
 1.43A 4or0A-5w7dA:
undetectable		 4or0A-5w7dA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 5 TYR A 415
GLN A 538
SER A 535
ASP A 332
 None
 1.47A 4qtuB-5w7dA:
2.1		 4qtuB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		3 / 3 THR A 304
SER A 335
ASP A 293
 None
 0.85A 5kvaB-5w7dA:
3.5		 5kvaB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 10 VAL A 500
PHE A 498
ILE A 364
VAL A 553
GLN A 549
 None
 1.16A 5nukA-5w7dA:
undetectable		 5nukA-5w7dA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		3 / 3 LEU A 427
LEU A 423
TRP A 461
 None
 0.80A 5nwuA-5w7dA:
undetectable		 5nwuA-5w7dA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 7 ARG A 325
ARG A 254
ALA A 539
GLN A 538
 None
 0.98A 6b89A-5w7dA:
undetectable		 6b89A-5w7dA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		3 / 3 ASN A 329
PRO A 253
GLN A 252
 None
 0.95A 6jnhA-5w7dA:
undetectable		 6jnhA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		3 / 3 ASP A 261
SER A 301
SER A 535
 None
 0.82A 6mxtA-5w7dA:
undetectable		 6mxtA-5w7dA:
undetectable