SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 10 ALA A 168
GLU A 167
LEU A 163
ILE A 230
LEU A 263
 None
 1.45A 1a52A-5w7mA:
undetectable		 1a52A-5w7mA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 9 ALA A 168
GLU A 167
LEU A 163
ILE A 230
LEU A 263
 None
 1.46A 1ereD-5w7mA:
undetectable		 1ereD-5w7mA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 ALA A  54
GLY A  56
ILE A  83
SER A  84
ALA A 110
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.5A)
 0.31A 1ve3A-5w7mA:
19.3		 1ve3A-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 ALA A  54
GLY A  56
ILE A  83
SER A  84
PHE A 132
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-4.5A)
 0.75A 1ve3A-5w7mA:
19.3		 1ve3A-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 TYR A  20
ALA A  54
ILE A  83
SER A  84
ALA A 110
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.5A)
 0.76A 1ve3A-5w7mA:
19.3		 1ve3A-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 TYR A  20
ALA A  54
ILE A  83
SER A  84
PHE A 132
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-4.5A)
 1.18A 1ve3A-5w7mA:
19.3		 1ve3A-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 ALA A  54
GLY A  56
ILE A  83
SER A  84
ALA A 110
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.5A)
 0.47A 1ve3B-5w7mA:
20.0		 1ve3B-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 ALA A  54
GLY A  56
ILE A  83
SER A  84
PHE A 132
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-4.5A)
 0.88A 1ve3B-5w7mA:
20.0		 1ve3B-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 ASP A  52
ILE A  83
SER A  84
ALA A 110
PHE A 132
 None
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
 1.21A 2ejtA-5w7mA:
12.6		 2ejtA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 4 THR A  27
THR A  57
ASP A  82
ASP A 109
 SAH  A 301 (-2.9A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.8A)
 0.90A 2f8lA-5w7mA:
13.7		 2f8lA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 6 THR A  27
THR A  57
ASP A  82
ASP A 109
 SAH  A 301 (-2.9A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.8A)
 1.01A 2okcA-5w7mA:
12.5		 2okcA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 6 THR A  27
THR A  57
ASP A  82
ASP A 109
 SAH  A 301 (-2.9A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.8A)
 1.05A 2okcB-5w7mA:
12.6		 2okcB-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 4 ALA A 137
VAL A 142
PHE A 132
THR A 113
 None
None
SAH  A 301 (-4.5A)
None
 1.33A 2pkkA-5w7mA:
3.1		 2pkkA-5w7mA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 GLY A  56
ILE A  83
ALA A 110
LEU A 127
THR A  27
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
SAH  A 301 (-2.9A)
 1.09A 3ckkA-5w7mA:
12.3		 3ckkA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 4 LEU A  64
ASP A  82
VAL A  59
THR A  31
 None
SAH  A 301 (-2.9A)
SAH  A 301 (-4.5A)
None
 1.29A 3cyxB-5w7mA:
undetectable		 3cyxB-5w7mA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 ALA A  54
GLY A  56
SER A  84
ASP A 109
ALA A 126
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.64A 3ou6A-5w7mA:
15.5		 3ou6A-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		3 / 3 GLY A  56
ASP A  82
ASP A 109
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.8A)
 0.36A 3ou7C-5w7mA:
15.2		 3ou7C-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 GLY A  56
ASP A  82
ILE A  83
ASP A 109
ALA A 128
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 3.9A)
 0.52A 4iv8A-5w7mA:
18.7		 4iv8A-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 GLY A  56
ASP A  82
ILE A  83
ASP A 109
ALA A 128
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 3.9A)
 0.53A 4iv8B-5w7mA:
18.7		 4iv8B-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 4 ILE A  35
SER A  38
ASP A  52
ASP A  82
 None
None
None
SAH  A 301 (-2.9A)
 1.23A 4krhB-5w7mA:
18.9		 4krhB-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		6 / 12 ALA A  54
SER A  84
ALA A 110
ALA A 126
SER A 131
PRO A 133
 SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 4.4A)
None
 0.47A 5jglA-5w7mA:
29.2		 5jglA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 THR A  27
ALA A  54
SER A  84
ALA A 110
ALA A 126
 SAH  A 301 (-2.9A)
SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
 0.64A 5jglA-5w7mA:
29.2		 5jglA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		6 / 12 ALA A  54
GLY A  56
ALA A 110
ALA A 126
SER A 131
PRO A 133
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 ( 4.4A)
None
 0.39A 5jglB-5w7mA:
29.8		 5jglB-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		5 / 12 THR A  27
ALA A  54
GLY A  56
ALA A 110
ALA A 126
 SAH  A 301 (-2.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
 0.66A 5jglB-5w7mA:
29.8		 5jglB-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 5 ALA A 125
VAL A 123
PHE A 129
ILE A 145
 None
 1.00A 5of1A-5w7mA:
undetectable		 5of1A-5w7mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		4 / 5 ALA A 125
VAL A 123
PHE A 129
ILE A 145
 None
 0.92A 5of1B-5w7mA:
undetectable		 5of1B-5w7mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN
(Penicillium
rubens) 		3 / 3 GLU A 196
HIS A 200
VAL A 213
 None
 0.57A 5trqB-5w7mA:
undetectable		 5trqB-5w7mA:
undetectable