SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 6 GLY A  90
THR A 133
PRO A 134
SER A 136
 None
 0.81A 1n4fA-5w7pA:
undetectable		 1n4fA-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 12 LEU A 197
HIS A 313
ASP A 314
SER A 245
PHE A 194
 None
None
SAM  A 501 ( 4.2A)
SAM  A 501 (-3.5A)
SAM  A 501 (-3.7A)
 1.23A 1uobA-5w7pA:
undetectable		 1uobA-5w7pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 6 THR A 250
ARG A 251
ASP A 269
ASP A 292
 None
None
SAM  A 501 (-2.7A)
SAM  A 501 (-3.4A)
 1.32A 2okcA-5w7pA:
8.5		 2okcA-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 7 ALA A 303
SER A 235
THR A 238
VAL A 240
 None
 0.92A 3ozkB-5w7pA:
undetectable		 3ozkB-5w7pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 12 PHE A 194
GLY A 244
PHE A 293
ARG A 310
ASP A 314
 SAM  A 501 (-3.7A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
 1.02A 4a6dA-5w7pA:
29.4		 4a6dA-5w7pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 12 PHE A 194
TYR A 198
VAL A 273
PHE A 293
ASP A 314
 SAM  A 501 (-3.7A)
SAM  A 501 (-4.8A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 4.2A)
 0.90A 4a6dA-5w7pA:
29.4		 4a6dA-5w7pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 12 PHE A 194
VAL A 273
PHE A 293
ARG A 310
ASP A 314
 SAM  A 501 (-3.7A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
 0.46A 4a6dA-5w7pA:
29.4		 4a6dA-5w7pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		6 / 12 PHE A 194
GLY A 244
PHE A 293
ARG A 310
ASP A 314
TRP A 315
 SAM  A 501 (-3.7A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
None
 1.13A 4a6eA-5w7pA:
29.0		 4a6eA-5w7pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		6 / 12 PHE A 194
VAL A 273
PHE A 293
ARG A 310
ASP A 314
TRP A 315
 SAM  A 501 (-3.7A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
None
 0.61A 4a6eA-5w7pA:
29.0		 4a6eA-5w7pA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 5 HIS A 342
GLY A 398
TYR A 223
GLU A 401
 None
 1.11A 4ae1B-5w7pA:
undetectable		 4ae1B-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 4 ILE A 305
SER A 304
ASP A 241
ASP A 269
 None
None
SAM  A 501 ( 4.8A)
SAM  A 501 (-2.7A)
 1.36A 4krhB-5w7pA:
13.4		 4krhB-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 6 SER A 354
GLU A 369
GLN A 358
VAL A 215
 None
 1.36A 4lnxA-5w7pA:
undetectable		 4lnxA-5w7pA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 8 SER A 245
HIS A 277
TYR A 198
GLU A 276
 SAM  A 501 (-3.5A)
None
SAM  A 501 (-4.8A)
None
 0.99A 4ms4A-5w7pA:
3.6		 4ms4A-5w7pA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		6 / 11 GLY A 244
THR A 250
ASP A 269
LEU A 270
VAL A 273
ASP A 292
 SAM  A 501 ( 3.8A)
None
SAM  A 501 (-2.7A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.4A)
 1.28A 4pghA-5w7pA:
20.9		 4pghA-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		6 / 12 ASP A 241
ASP A 269
LEU A 270
ASP A 292
ASP A 314
TRP A 315
 SAM  A 501 ( 4.8A)
SAM  A 501 (-2.7A)
SAM  A 501 (-4.3A)
SAM  A 501 (-3.4A)
SAM  A 501 ( 4.2A)
None
 0.74A 4pghB-5w7pA:
25.0		 4pghB-5w7pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 11 ASP A 269
LEU A 270
VAL A 273
ASP A 292
TRP A 315
 SAM  A 501 (-2.7A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.4A)
None
 0.60A 4pghC-5w7pA:
20.6		 4pghC-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 4 ILE A 365
ASN A 180
ILE A 162
VAL A 159
 None
 1.25A 4uy87-5w7pA:
undetectable		 4uy87-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 6 LEU A 140
SER A 136
PRO A 121
PHE A 135
 None
 1.30A 5b8iA-5w7pA:
undetectable		 5b8iA-5w7pA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 10 ILE A 339
ILE A 305
LEU A 239
ILE A 324
ASN A 327
 None
 1.20A 5vkqA-5w7pA:
4.0
5vkqD-5w7pA:
4.0		 5vkqA-5w7pA:
undetectable
5vkqD-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 10 ILE A 324
ASN A 327
ILE A 339
ILE A 305
LEU A 239
 None
 1.21A 5vkqA-5w7pA:
4.0
5vkqB-5w7pA:
4.0		 5vkqA-5w7pA:
undetectable
5vkqB-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 10 ILE A 324
ASN A 327
ILE A 339
ILE A 305
LEU A 239
 None
 1.20A 5vkqC-5w7pA:
4.0
5vkqD-5w7pA:
4.0		 5vkqC-5w7pA:
undetectable
5vkqD-5w7pA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W7P_A_SAMA501_0
(OXAC)		 5w7p OXAC
(Penicillium
oxalicum) 		7 / 12 ALA A 243
SER A 245
LEU A 270
VAL A 273
PHE A 293
LEU A 294
ARG A 309
 SAM  A 501 (-3.1A)
SAM  A 501 (-3.5A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 4.1A)
SAM  A 501 (-4.2A)
 1.08A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W7P_A_SAMA501_0
(OXAC)		 5w7p OXAC
(Penicillium
oxalicum) 		12 / 12 PHE A 194
GLU A 211
ALA A 243
GLY A 244
SER A 245
LEU A 270
VAL A 273
PHE A 293
LEU A 294
ARG A 310
ASP A 314
TRP A 315
 SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.1A)
SAM  A 501 ( 3.8A)
SAM  A 501 (-3.5A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 4.1A)
SAM  A 501 (-4.1A)
SAM  A 501 ( 4.2A)
None
 0.04A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 5w7p OXAC
(Penicillium
oxalicum) 		4 / 5 HIS A 246
ASP A 269
ASP A 292
ARG A 310
 SAM  A 501 (-3.8A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.1A)
 0.89A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 5w7p OXAC
(Penicillium
oxalicum) 		5 / 5 TYR A 198
HIS A 246
ASP A 269
ASP A 292
ARG A 309
 SAM  A 501 (-4.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.2A)
 0.01A 5w7pA-5w7pA:
61.0		 5w7pA-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5w7p OXAC
(Penicillium
oxalicum) 		6 / 12 TYR A 130
ALA A  85
THR A 102
LEU A 109
ILE A 108
LEU A  77
 None
 1.31A 6aybA-5w7pA:
undetectable		 6aybA-5w7pA:
11.68