SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.94A 1e7bA-5w7qA:
1.5		 1e7bA-5w7qA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 4 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.96A 1e7bB-5w7qA:
undetectable		 1e7bB-5w7qA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 ARG A 234
ALA A 294
ALA A 368
GLU A 370
 None
 0.97A 1e7cA-5w7qA:
undetectable		 1e7cA-5w7qA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		3 / 3 SER A 159
GLU A 160
GLU A 156
 None
 0.64A 1eqbD-5w7qA:
undetectable		 1eqbD-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		3 / 3 SER A 159
GLU A 160
GLU A 156
 None
 0.65A 1eqbB-5w7qA:
undetectable		 1eqbB-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 7 ASP A  87
GLY A  16
ILE A 103
THR A 116
 None
 0.68A 1t7iB-5w7qA:
undetectable		 1t7iB-5w7qA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 7 ASP A  87
GLY A  16
ILE A 103
THR A 116
 None
 0.67A 1t7jB-5w7qA:
undetectable		 1t7jB-5w7qA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 ALA A  53
ASN A  64
ILE A  63
ASP A  87
 None
 1.14A 1yc2D-5w7qA:
3.8		 1yc2D-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 ALA A  97
ASN A  14
ILE A  15
ASP A 100
 None
 1.18A 1yc2D-5w7qA:
3.8		 1yc2D-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 ALA A  53
ASN A  64
ILE A  63
ASP A  87
 None
 1.05A 2h4jA-5w7qA:
2.7		 2h4jA-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 ALA A  37
ALA A  42
GLN A  49
VAL A  68
 None
 0.87A 2nyrB-5w7qA:
3.5		 2nyrB-5w7qA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 12 GLY A  16
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 0.86A 2oz7A-5w7qA:
undetectable		 2oz7A-5w7qA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 6 VAL A 105
ASP A  81
HIS A  79
ASN A 136
 None
GDP  A 402 ( 4.8A)
None
GDP  A 402 (-2.9A)
 1.14A 2zs9A-5w7qA:
undetectable		 2zs9A-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 10 VAL A 105
ILE A 168
ILE A 200
PRO A 201
ILE A 103
 None
 1.20A 3clbD-5w7qA:
2.3		 3clbD-5w7qA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 12 LEU A 104
ASP A 162
GLY A 127
VAL A 126
ILE A 131
 None
 1.07A 3cyxA-5w7qA:
undetectable		 3cyxA-5w7qA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 9 GLY A 101
GLN A  98
VAL A 128
ILE A 103
VAL A 196
 None
 1.38A 3fi0F-5w7qA:
undetectable		 3fi0F-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 9 GLY A 101
GLN A  98
VAL A 128
ILE A 103
VAL A 196
 None
 1.43A 3fi0J-5w7qA:
undetectable		 3fi0J-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 7 GLY A 101
GLN A  98
VAL A 128
ILE A 103
 None
 0.85A 3fi0P-5w7qA:
undetectable		 3fi0P-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 10 VAL A 105
ILE A 168
ILE A 200
PRO A 201
ILE A 103
 None
 1.23A 3hbbD-5w7qA:
2.7		 3hbbD-5w7qA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 12 ILE A  15
GLY A 101
ALA A 123
ILE A 131
PRO A 203
 None
 1.04A 3jayA-5w7qA:
undetectable		 3jayA-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		3 / 3 THR A  65
ASN A  91
GLU A  56
 None
 0.75A 3v4tA-5w7qA:
undetectable
3v4tC-5w7qA:
undetectable		 3v4tA-5w7qA:
undetectable
3v4tC-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 THR A 383
LYS A  60
GLU A 316
PHE A 323
 None
 1.39A 4ac9C-5w7qA:
19.6		 4ac9C-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 THR A 383
LYS A  60
GLU A 316
PHE A 323
 None
 1.39A 4acaC-5w7qA:
19.4		 4acaC-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 9 PHE A 375
GLY A 318
GLY A 385
LEU A 312
GLU A 316
 None
 1.30A 4l8wI-5w7qA:
4.0		 4l8wI-5w7qA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 GLY A  84
ASP A  87
GLU A 118
VAL A 126
 None
 0.98A 4nkvD-5w7qA:
undetectable		 4nkvD-5w7qA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 6 ALA A  30
ASP A  81
LEU A 179
SER A 174
 None
GDP  A 402 ( 4.8A)
None
GDP  A 402 (-2.9A)
 1.11A 4ot2A-5w7qA:
undetectable		 4ot2A-5w7qA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 9 ALA A 123
GLY A  16
ALA A 102
ILE A 120
VAL A 105
 None
 1.01A 4r21B-5w7qA:
undetectable		 4r21B-5w7qA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 12 LEU A 122
LEU A 158
VAL A 133
VAL A 128
PHE A 163
 None
 1.18A 4wnwA-5w7qA:
undetectable		 4wnwA-5w7qA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 5 ALA A 294
ARG A 234
ALA A 368
GLU A 370
 None
 1.42A 5a06C-5w7qA:
3.3
5a06D-5w7qA:
2.9		 5a06C-5w7qA:
undetectable
5a06D-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 12 VAL A 243
VAL A 259
GLY A 275
ALA A 276
LEU A 278
 None
 1.26A 5iktB-5w7qA:
undetectable		 5iktB-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		4 / 6 LEU A 158
SER A 159
ARG A 124
ILE A 120
 None
 0.90A 5jw1A-5w7qA:
undetectable		 5jw1A-5w7qA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 12 LEU A 363
GLY A 290
PRO A 214
GLU A 216
THR A 336
 None
 1.14A 5x6yA-5w7qA:
undetectable		 5x6yA-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5w7q CONSENSUS ELONGATION
FACTOR
(synthetic
construct) 		5 / 9 LEU A 135
PRO A 112
VAL A 133
SER A 159
LEU A 157
 None
 1.37A 6fdyU-5w7qA:
undetectable		 6fdyU-5w7qA:
13.04