SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 11 PHE A 353
ILE A 362
ILE A 271
LEU A 287
PHE A 267
 None
 1.06A 1z11B-5w7zA:
undetectable		 1z11B-5w7zA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 5 SER A 354
ASP A 355
PRO A 359
SER A 256
 None
 1.43A 2hdnA-5w7zA:
undetectable
2hdnB-5w7zA:
undetectable
2hdnD-5w7zA:
undetectable		 2hdnA-5w7zA:
8.45
2hdnB-5w7zA:
22.82
2hdnD-5w7zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 5 SER A 256
SER A 354
ASP A 355
PRO A 359
 None
 1.47A 2hdnB-5w7zA:
undetectable
2hdnC-5w7zA:
undetectable
2hdnD-5w7zA:
undetectable		 2hdnB-5w7zA:
22.82
2hdnC-5w7zA:
8.45
2hdnD-5w7zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 7 ARG A 176
PHE A 372
ILE A 362
PHE A 364
 None
 1.01A 2qb4A-5w7zA:
undetectable		 2qb4A-5w7zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 12 LEU A 289
LEU A 294
MET A 266
ARG A 273
LEU A 351
 None
 1.26A 2w8yB-5w7zA:
undetectable		 2w8yB-5w7zA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 12 LEU A 160
LEU A 195
ILE A 130
SER A 238
VAL A 207
 None
 1.28A 3aqiB-5w7zA:
undetectable		 3aqiB-5w7zA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 4 ILE A 217
PHE A 228
ILE A 219
THR A 234
 None
 1.13A 3ia4A-5w7zA:
undetectable		 3ia4A-5w7zA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 8 THR A   8
LEU A  87
LEU A  89
ILE A  99
 None
 0.80A 3nbqB-5w7zA:
undetectable		 3nbqB-5w7zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 8 THR A   8
LEU A  87
LEU A  89
ILE A  99
 None
 0.74A 3nbqC-5w7zA:
undetectable		 3nbqC-5w7zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 12 ILE A 217
ILE A 130
LEU A 184
ILE A 162
LEU A 221
 None
 1.29A 3w67D-5w7zA:
undetectable		 3w67D-5w7zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 6 ILE A 296
ILE A 330
PHE A 267
LEU A 337
 None
 0.97A 4m51A-5w7zA:
undetectable		 4m51A-5w7zA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		7 / 9 ARG A 152
THR A 172
GLY A 174
LEU A 177
PRO A 246
VAL A 373
MET A 375
 None
MRD  A 403 (-3.1A)
MRD  A 403 (-3.8A)
MRD  A 403 ( 4.0A)
None
MRD  A 403 ( 4.7A)
MRD  A 403 ( 4.5A)
 0.96A 4mjrA-5w7zA:
41.7		 4mjrA-5w7zA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 7 PRO A 210
ASP A 209
SER A  20
PHE A  17
 None
 1.32A 4ndnC-5w7zA:
undetectable		 4ndnC-5w7zA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 12 LEU A 195
ALA A 200
THR A 234
ILE A 219
ILE A 217
 None
 1.06A 4o2bB-5w7zA:
undetectable		 4o2bB-5w7zA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 7 PRO A 210
ASP A 209
SER A  20
PHE A  17
 None
 1.24A 4odjA-5w7zA:
undetectable		 4odjA-5w7zA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 12 GLN A  56
LEU A  43
ALA A  18
LEU A  75
ASN A  76
 None
 1.39A 4qdcA-5w7zA:
undetectable		 4qdcA-5w7zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		3 / 3 THR A 293
ASN A 311
SER A 312
 None
 0.77A 4tvtA-5w7zA:
undetectable		 4tvtA-5w7zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		4 / 7 LEU A 155
THR A 172
PRO A 246
MET A 375
 None
MRD  A 403 (-3.1A)
None
MRD  A 403 ( 4.5A)
 0.79A 5fxtA-5w7zA:
38.1		 5fxtA-5w7zA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 8 THR A 172
LEU A 177
PRO A 246
PRO A 359
MET A 375
 MRD  A 403 (-3.1A)
MRD  A 403 ( 4.0A)
None
None
MRD  A 403 ( 4.5A)
 0.68A 5g48A-5w7zA:
37.9		 5g48A-5w7zA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		6 / 9 LEU A 155
THR A 172
LEU A 177
PRO A 246
PRO A 359
MET A 375
 None
MRD  A 403 (-3.1A)
MRD  A 403 ( 4.0A)
None
None
MRD  A 403 ( 4.5A)
 0.77A 5g48B-5w7zA:
10.3		 5g48B-5w7zA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 12 LEU A 195
ALA A 200
THR A 234
ILE A 219
ILE A 217
 None
 1.04A 5mioB-5w7zA:
undetectable		 5mioB-5w7zA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 12 LEU A 108
LEU A  75
SER A  47
SER A  46
LEU A  45
 None
 1.21A 5mwyA-5w7zA:
undetectable		 5mwyA-5w7zA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		5 / 9 VAL A 340
LEU A 337
PHE A 332
VAL A 360
ILE A 362
 None
 1.07A 5om2A-5w7zA:
undetectable
5om2B-5w7zA:
undetectable		 5om2A-5w7zA:
13.68
5om2B-5w7zA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		3 / 3 GLU A 338
TYR A 336
ARG A 176
 None
 0.62A 5uunA-5w7zA:
undetectable		 5uunA-5w7zA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5w7z DNA POLYMERASE III
SUBUNIT BETA
(Rickettsia
conorii) 		3 / 3 GLU A 338
TYR A 336
ARG A 176
 None
 0.56A 5uunB-5w7zA:
undetectable		 5uunB-5w7zA:
23.26