SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		4 / 7 TYR A  48
ASP A  50
ASP A  49
HIS A  20
 MTA  A 301 (-4.8A)
None
None
None
 1.21A 1t03A-5w8dA:
undetectable		 1t03A-5w8dA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		3 / 3 ARG A  69
ARG A  24
ILE A   5
 None
 0.72A 1uobA-5w8dA:
undetectable		 1uobA-5w8dA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		4 / 6 VAL A  64
VAL A  65
GLN A 118
ARG A  63
 None
 0.95A 3bjwF-5w8dA:
undetectable		 3bjwF-5w8dA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		5 / 12 PHE A  83
LEU A  86
PRO A  93
ILE A  98
TRP A 143
 MTA  A 301 (-4.6A)
None
None
None
GOL  A 302 (-3.5A)
 1.36A 5dlvA-5w8dA:
undetectable		 5dlvA-5w8dA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		5 / 12 PHE A  83
LEU A  86
PRO A  93
ILE A  98
TRP A 143
 MTA  A 301 (-4.6A)
None
None
None
GOL  A 302 (-3.5A)
 1.37A 5dlvB-5w8dA:
undetectable		 5dlvB-5w8dA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		3 / 3 ALA A 204
ASN A 207
LEU A 208
 None
 0.38A 5i1oC-5w8dA:
undetectable		 5i1oC-5w8dA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		3 / 3 ALA A 204
ASN A 207
LEU A 208
 None
 0.35A 5i1pA-5w8dA:
undetectable		 5i1pA-5w8dA:
10.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		5 / 12 MET A  78
VAL A  82
SER A 102
ARG A  69
ILE A 138
 MTA  A 301 (-3.6A)
MTA  A 301 (-4.7A)
None
None
MTA  A 301 (-4.2A)
 1.41A 5w8aA-5w8dA:
40.3		 5w8aA-5w8dA:
99.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		12 / 12 TRP A  34
THR A  36
LEU A  37
TYR A  48
MET A  78
VAL A  82
PHE A  83
SER A 102
ARG A 103
ILE A 138
GLU A 164
THR A 168
 MTA  A 301 (-3.8A)
MTA  A 301 (-3.6A)
MTA  A 301 ( 4.9A)
MTA  A 301 (-4.8A)
MTA  A 301 (-3.6A)
MTA  A 301 (-4.7A)
MTA  A 301 (-4.6A)
None
MTA  A 301 ( 3.0A)
MTA  A 301 (-4.2A)
None
MTA  A 301 ( 4.5A)
 0.37A 5w8aA-5w8dA:
40.3		 5w8aA-5w8dA:
99.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		5 / 10 CYH A 127
VAL A  54
VAL A 193
ALA A   4
LEU A  70
 None
 1.09A 6czmA-5w8dA:
undetectable
6czmC-5w8dA:
undetectable		 6czmA-5w8dA:
19.94
6czmC-5w8dA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5w8d AUTOINDUCER SYNTHASE
(Bradyrhizobium
japonicum) 		4 / 5 ARG A  38
ARG A  39
GLY A  42
ASP A  41
 None
 1.27A 6dwjB-5w8dA:
undetectable
6dwjD-5w8dA:
undetectable		 6dwjB-5w8dA:
17.01
6dwjD-5w8dA:
17.01