SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		5 / 12 LEU A  11
ASN A  10
GLY A  40
VAL A  61
LEU A   6
 None
 0.96A 1nhzA-5w8mA:
undetectable		 1nhzA-5w8mA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		5 / 12 LEU A   6
LEU A  51
ILE A  20
THR A 139
LEU A 159
 None
 1.16A 2jn3A-5w8mA:
undetectable		 2jn3A-5w8mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		5 / 11 CYH A  38
LEU A  37
LEU A  51
LEU A   6
ALA A 138
 None
 1.30A 3e22B-5w8mA:
undetectable		 3e22B-5w8mA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		4 / 5 ASP A 145
SER A  95
VAL A  94
GLY A 118
 None
 1.07A 3rxhA-5w8mA:
undetectable		 3rxhA-5w8mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		4 / 7 LEU A  93
VAL A  94
PRO A  98
GLU A 104
 None
 1.09A 4lb2A-5w8mA:
undetectable		 4lb2A-5w8mA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		3 / 3 VAL A 184
TYR A 172
GLN A 173
 None
 0.57A 5qgkA-5w8mA:
undetectable		 5qgkA-5w8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		3 / 3 VAL A 184
TYR A 172
GLN A 173
 None
 0.56A 5qgrA-5w8mA:
undetectable		 5qgrA-5w8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		3 / 3 VAL A 184
TYR A 172
GLN A 173
 None
 0.57A 5qgtA-5w8mA:
undetectable		 5qgtA-5w8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Chaetomium
thermophilum) 		3 / 3 GLY A  86
VAL A 162
MET A 160
 None
 0.63A 5ycpA-5w8mA:
undetectable		 5ycpA-5w8mA:
21.59