SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		3 / 3 PHE A 193
TYR A  31
TYR A  26
 BU4  A 400 (-4.0A)
BU4  A 400 (-4.5A)
None
 1.07A 1x70B-5w8qA:
undetectable		 1x70B-5w8qA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 8 ILE A 218
ALA A 105
LEU A 139
ILE A 119
 None
 0.69A 2w9sE-5w8qA:
undetectable		 2w9sE-5w8qA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		5 / 12 ILE A 234
MET A 278
PHE A 282
LEU A 321
THR A 324
 None
 1.35A 3em0B-5w8qA:
undetectable		 3em0B-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 8 VAL A 184
LEU A 182
ILE A 123
ASP A 136
 None
 0.70A 3wzeA-5w8qA:
undetectable		 3wzeA-5w8qA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		5 / 9 TYR A 260
ALA A 208
ARG A  48
ARG A  53
ILE A  54
 None
 1.31A 4oknB-5w8qA:
undetectable		 4oknB-5w8qA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 6 LEU A 381
PHE A 296
ILE A 368
PHE A 297
 None
 1.25A 4y4dA-5w8qA:
undetectable		 4y4dA-5w8qA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 8 VAL A 249
TYR A 260
GLY A 302
GLY A 335
 None
 0.83A 5e26C-5w8qA:
undetectable
5e26D-5w8qA:
undetectable		 5e26C-5w8qA:
undetectable
5e26D-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 6 ALA A 323
THR A 324
VAL A 327
VAL A 367
 None
 1.01A 5eckD-5w8qA:
undetectable		 5eckD-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 6 ALA A 323
THR A 324
VAL A 327
VAL A 367
 None
 0.90A 5eclA-5w8qA:
undetectable		 5eclA-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 7 HIS A 300
ILE A 342
VAL A 299
ARG A 325
 None
 1.25A 5kkzC-5w8qA:
undetectable
5kkzE-5w8qA:
undetectable		 5kkzC-5w8qA:
undetectable
5kkzE-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 7 HIS A 300
ILE A 342
VAL A 299
ARG A 325
 None
 1.20A 5kkzK-5w8qA:
undetectable
5kkzQ-5w8qA:
undetectable		 5kkzK-5w8qA:
undetectable
5kkzQ-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 4 LEU A  65
MET A 334
ILE A  92
LEU A 100
 BU4  A 400 ( 3.8A)
None
None
None
 1.17A 5nfpA-5w8qA:
undetectable		 5nfpA-5w8qA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		5 / 12 LEU A 143
SER A 215
ALA A  16
ALA A 108
GLY A  18
 None
 1.18A 5tzoB-5w8qA:
undetectable		 5tzoB-5w8qA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_2
(BETA-LACTAMASE)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 4 CYH A 185
ILE A 188
PRO A  98
THR A 338
 None
 1.17A 6b68D-5w8qA:
0.0		 6b68D-5w8qA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		5 / 12 TRP A 292
ASP A 286
ALA A 236
GLY A 365
PHE A 297
 None
 1.24A 6clxA-5w8qA:
undetectable		 6clxA-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 6 VAL A 184
LEU A 139
LEU A 145
LEU A 106
 None
 1.00A 6f6sA-5w8qA:
0.0
6f6sB-5w8qA:
undetectable		 6f6sA-5w8qA:
19.28
6f6sB-5w8qA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 8 ILE A 241
GLN A 239
THR A 164
VAL A 165
 None
 0.86A 6fbvC-5w8qA:
0.3		 6fbvC-5w8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 6 TYR A  26
ASN A  21
TYR A  64
GLU A 103
 None
 1.42A 6gneA-5w8qA:
undetectable		 6gneA-5w8qA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5w8q BIS3 BIPHENYL
SYNTHASE
(Malus
domestica) 		4 / 8 LYS A 177
GLY A 178
GLY A 220
GLU A 224
 None
 0.86A 6mdqA-5w8qA:
undetectable		 6mdqA-5w8qA:
21.11