SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL A  90
LEU A  86
PHE A  83
LEU A  80
TYR A  72
 None
None
MPD  A 405 ( 4.7A)
None
None
 1.36A 1kw0A-5w8uA:
undetectable		 1kw0A-5w8uA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 11 ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
 None
 1.30A 1tw4A-5w8uA:
undetectable		 1tw4A-5w8uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 11 MET A 185
LEU A 218
SER A 247
LEU A 246
ASP A 309
 None
 1.29A 2c12F-5w8uA:
undetectable		 2c12F-5w8uA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 1.00A 2feuB-5w8uA:
undetectable		 2feuB-5w8uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQD_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 4 TYR A 279
ASN A 114
CYH A 111
TYR A 112
 None
None
AYE  A 404 (-1.7A)
None
 1.41A 2kqdA-5w8uA:
0.0		 2kqdA-5w8uA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 1.05A 2zwtA-5w8uA:
undetectable		 2zwtA-5w8uA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 1.04A 3fwjA-5w8uA:
undetectable		 3fwjA-5w8uA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 0.79A 3lm8A-5w8uA:
undetectable
3lm8C-5w8uA:
undetectable		 3lm8A-5w8uA:
19.14
3lm8C-5w8uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 1.00A 3lm8B-5w8uA:
undetectable
3lm8D-5w8uA:
undetectable		 3lm8B-5w8uA:
19.14
3lm8D-5w8uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 1.00A 3wrhA-5w8uA:
undetectable		 3wrhA-5w8uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 1.03A 3wrlA-5w8uA:
undetectable		 3wrlA-5w8uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 1.03A 3wrmA-5w8uA:
undetectable		 3wrmA-5w8uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 LYS A 291
ALA A 282
LEU A 284
VAL A 268
 None
 0.96A 4ik6B-5w8uA:
undetectable		 4ik6B-5w8uA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 6 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 0.95A 4l4cA-5w8uA:
undetectable		 4l4cA-5w8uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 TYR A  26
LEU A  54
VAL A   6
ASP A  46
 None
 0.95A 4l4gA-5w8uA:
undetectable		 4l4gA-5w8uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 5 ARG A 221
ASP A 320
GLU A 189
VAL A 200
 None
 1.28A 4nkvB-5w8uA:
undetectable		 4nkvB-5w8uA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 LYS A  87
ASN A 110
ASP A 147
 MPD  A 405 (-3.1A)
None
MPD  A 405 ( 4.4A)
 0.86A 4o1eA-5w8uA:
undetectable		 4o1eA-5w8uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 PHE A 269
SER A 167
ALA A 166
PRO A 250
 None
 0.89A 5dzkD-5w8uA:
undetectable
5dzkR-5w8uA:
undetectable		 5dzkD-5w8uA:
20.73
5dzkR-5w8uA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 GLY A 230
CYH A 228
CYH A 226
 None
ZN  A 401 (-2.2A)
ZN  A 401 (-2.3A)
 0.98A 5inzB-5w8uA:
undetectable		 5inzB-5w8uA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 6 PHE A 263
VAL A 310
ALA A 265
THR A 119
 None
 0.85A 5t7bA-5w8uA:
undetectable		 5t7bA-5w8uA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5w8u ORF1AB PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 5 LEU A  80
VAL A  10
GLU A  64
LEU A  60
 None
 1.12A 5xooB-5w8uA:
undetectable		 5xooB-5w8uA:
13.79