SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.78A 1c8lA-5w8xA:
undetectable		 1c8lA-5w8xA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.82A 1gfzA-5w8xA:
6.9		 1gfzA-5w8xA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.79A 1l5qA-5w8xA:
undetectable		 1l5qA-5w8xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.76A 1l5qB-5w8xA:
3.3		 1l5qB-5w8xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.80A 1l7xA-5w8xA:
4.8		 1l7xA-5w8xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.83A 1l7xB-5w8xA:
undetectable		 1l7xB-5w8xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		6 / 12 THR A 167
ILE A  26
GLY A  22
GLY A  18
SER A  17
PHE A  38
 None
 1.25A 1vq1B-5w8xA:
3.6		 1vq1B-5w8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 4 VAL A 159
TYR A 157
VAL A 133
SER A 122
 None
 1.38A 2x45B-5w8xA:
undetectable		 2x45B-5w8xA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 140
ILE A 136
GLY A 137
HIS A 119
PRO A 123
 None
 1.22A 2y7kA-5w8xA:
2.2		 2y7kA-5w8xA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 140
ILE A 136
GLY A 137
HIS A 119
PRO A 123
 None
 1.20A 2y7kB-5w8xA:
2.6		 2y7kB-5w8xA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		6 / 12 THR A 140
ILE A 136
GLY A 137
HIS A 119
PRO A 123
ARG A 132
 None
 1.39A 2y7kC-5w8xA:
undetectable		 2y7kC-5w8xA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 140
ILE A 136
GLY A 137
HIS A 119
PRO A 123
 None
 1.29A 2y7pA-5w8xA:
2.6		 2y7pA-5w8xA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  22
GLY A  18
SER A  17
ALA A  42
PHE A  38
 None
 1.07A 2yvlA-5w8xA:
4.2		 2yvlA-5w8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 5 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.78A 3bcrA-5w8xA:
6.2		 3bcrA-5w8xA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.78A 3dd1A-5w8xA:
6.1		 3dd1A-5w8xA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.80A 3dd1B-5w8xA:
undetectable		 3dd1B-5w8xA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.78A 3ddsA-5w8xA:
4.8		 3ddsA-5w8xA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.77A 3ddsB-5w8xA:
4.8		 3ddsB-5w8xA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.77A 3ddwA-5w8xA:
undetectable		 3ddwA-5w8xA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 103
PHE A 102
ALA A  99
GLY A  14
 None
 0.77A 3ddwB-5w8xA:
undetectable		 3ddwB-5w8xA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 6 LEU A 194
SER A 268
ALA A 267
LEU A 226
 None
 0.87A 3rd0A-5w8xA:
undetectable		 3rd0A-5w8xA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 4 SER A 122
ILE A 104
TYR A 154
PRO A 100
 None
 1.48A 4jkuB-5w8xA:
6.1		 4jkuB-5w8xA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_2
(SUGAR KINASE)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 4 SER A 122
ILE A 104
TYR A 154
PRO A 100
 None
 1.48A 4k8pA-5w8xA:
6.4		 4k8pA-5w8xA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_2
(SUGAR KINASE)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 4 SER A 122
ILE A 104
TYR A 154
PRO A 100
 None
 1.48A 4k8pB-5w8xA:
6.1		 4k8pB-5w8xA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_2
(SUGAR KINASE)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 4 SER A 122
ILE A 104
TYR A 154
PRO A 100
 None
 1.49A 4k8tB-5w8xA:
6.2		 4k8tB-5w8xA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_2
(SUGAR KINASE)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 4 SER A 122
ILE A 104
TYR A 154
PRO A 100
 None
 1.48A 4k93A-5w8xA:
6.9		 4k93A-5w8xA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A  79
GLU A 107
PHE A  94
 None
 0.89A 4kszA-5w8xA:
undetectable		 4kszA-5w8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		4 / 4 SER A 122
ILE A 104
TYR A 154
PRO A 100
 None
 1.50A 4lbxB-5w8xA:
6.3		 4lbxB-5w8xA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		5 / 12 CYH A 282
LEU A 273
ALA A 278
ALA A 264
ALA A 271
 None
None
UDP  A 401 ( 3.4A)
None
None
 1.14A 4x1iB-5w8xA:
4.7		 4x1iB-5w8xA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A  27
LYS A  30
ARG A   5
 None
 1.15A 6c06D-5w8xA:
undetectable		 6c06D-5w8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  41
ASP A 101
PHE A 102
PHE A  94
PHE A  86
 None
 1.00A 6iblA-5w8xA:
undetectable		 6iblA-5w8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5w8x LIPID-A-DISACCHARIDE
SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  41
ASP A 101
PHE A 102
PHE A  94
PHE A  86
 None
 0.95A 6iblB-5w8xA:
2.0		 6iblB-5w8xA:
undetectable