SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 SER A 393
GLY B  31
LEU B  32
VAL B  27
PHE A 369
 None
 1.50A 1a27A-5w94A:
undetectable		 1a27A-5w94A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 SER A  33
GLU A  34
GLU A  35
 None
 0.54A 1eqbD-5w94A:
undetectable		 1eqbD-5w94A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 SER A  33
GLU A  34
GLU A  35
 None
 0.54A 1eqbB-5w94A:
undetectable		 1eqbB-5w94A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 184
VAL A 142
TYR A 162
TRP A 194
 None
 1.02A 1lweA-5w94A:
undetectable		 1lweA-5w94A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 8 SER B  53
THR B  52
LEU A  63
GLU A 109
 None
 1.14A 1mxgA-5w94B:
undetectable		 1mxgA-5w94B:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 249
LEU B  26
TYR B  25
LEU A 476
LEU A 471
 None
 1.42A 1p33A-5w94A:
undetectable		 1p33A-5w94A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 249
LEU B  26
TYR B  25
LEU A 476
LEU A 471
 None
 1.44A 1p33B-5w94A:
undetectable		 1p33B-5w94A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 THR A 359
GLU A 352
HIS A 297
 None
 0.91A 1xwfA-5w94A:
undetectable		 1xwfA-5w94A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 THR A 359
GLU A 352
HIS A 297
 None
 0.91A 1xwfB-5w94A:
undetectable		 1xwfB-5w94A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 THR A 359
GLU A 352
HIS A 297
 None
 0.91A 1xwfC-5w94A:
undetectable		 1xwfC-5w94A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 THR A 359
GLU A 352
HIS A 297
 None
 0.90A 1xwfD-5w94A:
undetectable		 1xwfD-5w94A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 164
SER A 180
VAL A 142
LEU A 135
 None
 1.27A 1yajB-5w94A:
undetectable		 1yajB-5w94A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 221
LEU A 218
LEU A 206
LEU A 207
 None
 0.92A 2ab2B-5w94A:
undetectable		 2ab2B-5w94A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 236
GLY A 277
GLY A 230
GLN A 193
 None
 0.89A 2qx6A-5w94A:
undetectable
2qx6B-5w94A:
undetectable		 2qx6A-5w94A:
17.31
2qx6B-5w94A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 411
GLY A 410
GLN A 406
VAL A 405
CYH A 460
 None
 1.08A 3h52B-5w94A:
undetectable		 3h52B-5w94A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU A  35
GLY A  36
ILE A  27
GLY A  32
PHE B  92
 None
 1.24A 3ps9A-5w94A:
undetectable		 3ps9A-5w94A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 544
LEU A 548
THR A 485
LEU A 435
LEU A 489
 None
 1.44A 3q1eB-5w94A:
undetectable
3q1eD-5w94A:
undetectable		 3q1eB-5w94A:
10.29
3q1eD-5w94A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 488
PHE A 492
ILE A 588
TYR B  25
THR A 439
 None
 1.47A 3qg2A-5w94A:
undetectable		 3qg2A-5w94A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 SER A 312
PHE A 324
LYS A 321
 None
 0.85A 3u88A-5w94A:
2.7		 3u88A-5w94A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 483
ARG A 210
ILE A 481
TRP A 482
 None
 1.44A 4cx7C-5w94A:
undetectable
4cx7D-5w94A:
0.0		 4cx7C-5w94A:
22.73
4cx7D-5w94A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 489
LEU A 545
ILE B  15
ILE B  14
LEU A 552
 None
 1.16A 4j24A-5w94A:
undetectable		 4j24A-5w94A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 489
LEU A 545
ILE B  15
ILE B  14
LEU A 552
 None
 1.18A 4j24B-5w94A:
undetectable		 4j24B-5w94A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  17
SER A  47
ARG A  21
TYR A  14
 None
 1.02A 4lv9A-5w94A:
undetectable
4lv9B-5w94A:
undetectable		 4lv9A-5w94A:
22.90
4lv9B-5w94A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  14
ALA A  17
SER A  47
ARG A  21
 None
 1.03A 4lv9A-5w94A:
undetectable
4lv9B-5w94A:
undetectable		 4lv9A-5w94A:
22.90
4lv9B-5w94A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ALA B  17
ILE B  14
GLY B  12
GLY A 589
ILE A 588
 None
 1.01A 4q5mA-5w94B:
undetectable		 4q5mA-5w94B:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 592
ASN A 595
ALA A 599
 None
 0.31A 5n4tB-5w94A:
undetectable		 5n4tB-5w94A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 411
GLY A 410
GLN A 406
VAL A 405
CYH A 460
 None
 0.93A 5uc1A-5w94A:
2.1		 5uc1A-5w94A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 411
GLY A 410
GLN A 406
VAL A 405
CYH A 460
 None
 0.95A 5uc1B-5w94A:
2.1		 5uc1B-5w94A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 563
TYR A 565
ARG A 601
 None
 0.77A 5uunA-5w94A:
1.7		 5uunA-5w94A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 563
TYR A 565
ARG A 601
 None
 0.59A 5uunB-5w94A:
undetectable		 5uunB-5w94A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  79
THR A  80
THR A  69
LEU A 116
 None
 1.47A 5v96A-5w94A:
undetectable		 5v96A-5w94A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  79
THR A  80
THR A  69
LEU A 116
 None
 1.49A 5v96B-5w94A:
undetectable		 5v96B-5w94A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  79
THR A  80
THR A  69
LEU A 116
 None
 1.48A 5v96C-5w94A:
undetectable		 5v96C-5w94A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 4 GLU A  79
THR A  80
THR A  69
LEU A 116
 None
 1.47A 5v96D-5w94A:
undetectable		 5v96D-5w94A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 175
LYS A 469
ARG A 176
 None
 1.38A 6az3C-5w94A:
1.8
6az3L-5w94A:
undetectable
6az3M-5w94A:
undetectable		 6az3C-5w94A:
9.55
6az3L-5w94A:
9.48
6az3M-5w94A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 MET A 294
ILE A 304
LEU A 308
THR A 359
LEU A 246
 None
 1.25A 6b54A-5w94A:
undetectable		 6b54A-5w94A:
16.01