SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 132
GLN A 139
PHE A 130
TRP A  84
 1PE  A 402 (-3.7A)
None
1PE  A 402 (-3.5A)
None
 1.34A 1p6kA-5w95A:
undetectable		 1p6kA-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 290
GLY A 177
GLY A  82
ILE A 270
THR A 244
 1PE  A 401 (-4.4A)
None
None
1PE  A 401 (-4.3A)
None
 1.06A 1p91B-5w95A:
undetectable		 1p91B-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 132
GLN A 139
PHE A 130
TRP A  84
 1PE  A 402 (-3.7A)
None
1PE  A 402 (-3.5A)
None
 1.32A 1rs6A-5w95A:
undetectable		 1rs6A-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 132
GLN A 139
PHE A 130
TRP A  84
 1PE  A 402 (-3.7A)
None
1PE  A 402 (-3.5A)
None
 1.35A 1zzqA-5w95A:
undetectable		 1zzqA-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 11 THR A 246
MET A 245
THR A 231
ALA A 228
VAL A 179
 None
1PE  A 401 ( 4.3A)
None
1PE  A 401 ( 4.0A)
None
 1.39A 2cojA-5w95A:
undetectable
2cojB-5w95A:
undetectable		 2cojA-5w95A:
12.23
2cojB-5w95A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 142
GLY A 227
ALA A 228
LEU A 232
 1PE  A 401 (-4.6A)
None
1PE  A 401 ( 4.0A)
1PE  A 401 ( 4.9A)
 0.88A 2wekB-5w95A:
3.4		 2wekB-5w95A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 6 GLN A  76
ALA A 152
ALA A 155
THR A 158
 None
 1.00A 2xfhA-5w95A:
undetectable		 2xfhA-5w95A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 210
MET A 245
THR A 244
LEU A 243
 None
1PE  A 401 ( 4.3A)
None
None
 1.43A 3ag1J-5w95A:
undetectable		 3ag1J-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 205
ALA A 323
MET A 157
GLN A  76
TYR A 122
 None
 1.45A 3cldA-5w95A:
undetectable		 3cldA-5w95A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 287
PHE A 130
PHE A 278
VAL A 235
ALA A 228
 None
1PE  A 402 (-3.5A)
None
None
1PE  A 401 ( 4.0A)
 1.27A 3nhxA-5w95A:
undetectable		 3nhxA-5w95A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 7 THR A 231
LEU A 232
THR A 286
LEU A 290
 None
1PE  A 401 ( 4.9A)
None
1PE  A 401 (-4.4A)
 0.95A 4z91F-5w95A:
undetectable
4z91G-5w95A:
undetectable
4z91H-5w95A:
undetectable
4z91I-5w95A:
undetectable
4z91J-5w95A:
undetectable		 4z91F-5w95A:
12.30
4z91G-5w95A:
12.30
4z91H-5w95A:
12.30
4z91I-5w95A:
12.30
4z91J-5w95A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 156
ASP A 187
GLY A 182
THR A 246
 None
 1.00A 5btdA-5w95A:
undetectable
5btdC-5w95A:
undetectable
5btdD-5w95A:
3.1		 5btdA-5w95A:
9.20
5btdC-5w95A:
9.20
5btdD-5w95A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 303
TYR A 302
PRO A 297
LEU A 269
 None
 0.98A 5eslA-5w95A:
undetectable		 5eslA-5w95A:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 188
VAL A 203
TYR A 169
VAL A 200
 None
 1.00A 5jwaH-5w95A:
undetectable		 5jwaH-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 4 GLN A  76
THR A 121
THR A 204
LEU A 326
 None
 1.49A 5m5kA-5w95A:
5.6		 5m5kA-5w95A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 210
MET A 245
THR A 244
LEU A 243
 None
1PE  A 401 ( 4.3A)
None
None
 1.36A 5x1fW-5w95A:
undetectable		 5x1fW-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 253
ILE A 180
ALA A 181
LEU A 205
PHE A 278
 None
 1.48A 5zjiA-5w95A:
undetectable
5zjiJ-5w95A:
undetectable		 5zjiA-5w95A:
21.28
5zjiJ-5w95A:
18.75