SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5w99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 5w99 PBTD
(Planobispora
rosea) 		4 / 6 HIS A  38
ARG A 113
GLU A  92
GLN A  93
 None
 1.39A 2qqtA-5w99A:
undetectable		 2qqtA-5w99A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5w99 PBTD
(Planobispora
rosea) 		5 / 11 SER A  55
PHE A  49
ARG A  23
PRO A  24
SER A  33
 None
 1.50A 2trtA-5w99A:
undetectable		 2trtA-5w99A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5w99 PBTD
(Planobispora
rosea) 		4 / 5 SER A 178
TYR A 285
PHE A 179
VAL A 317
 A1V  A 401 (-2.8A)
None
None
None
 1.47A 2x7hB-5w99A:
undetectable		 2x7hB-5w99A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5w99 PBTD
(Planobispora
rosea) 		4 / 6 HIS A  38
ARG A 113
GLU A  92
GLN A  93
 None
 1.36A 3gclA-5w99A:
0.0		 3gclA-5w99A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5w99 PBTD
(Planobispora
rosea) 		4 / 7 LEU A 266
ARG A 180
SER A 279
GLY A 175
 A1V  A 401 (-4.3A)
None
None
A1V  A 401 ( 4.8A)
 1.08A 3hcrB-5w99A:
undetectable		 3hcrB-5w99A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5w99 PBTD
(Planobispora
rosea) 		3 / 3 LEU A 277
ARG A 278
ARG A 283
 None
 0.85A 4yiaB-5w99A:
undetectable		 4yiaB-5w99A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5w99 PBTD
(Planobispora
rosea) 		4 / 5 LEU A  45
LEU A 107
LEU A  25
HIS A  66
 None
 1.01A 5gtrA-5w99A:
undetectable		 5gtrA-5w99A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5w99 PBTD
(Planobispora
rosea) 		4 / 6 HIS A 311
ARG A 202
GLU A 198
TYR A 201
 None
 1.06A 5x7pA-5w99A:
undetectable		 5x7pA-5w99A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5w99 PBTD
(Planobispora
rosea) 		4 / 6 HIS A 311
ARG A 202
GLU A 198
TYR A 201
 None
 1.01A 5x7qA-5w99A:
undetectable		 5x7qA-5w99A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5w99 PBTD
(Planobispora
rosea) 		4 / 6 HIS A 311
ARG A 202
GLU A 198
TYR A 201
 None
 1.01A 5x7qB-5w99A:
undetectable		 5x7qB-5w99A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5w99 PBTD
(Planobispora
rosea) 		4 / 6 HIS A 311
ARG A 202
GLU A 198
TYR A 201
 None
 1.01A 5x7rA-5w99A:
undetectable		 5x7rA-5w99A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5w99 PBTD
(Planobispora
rosea) 		4 / 6 HIS A 311
ARG A 202
GLU A 198
TYR A 201
 None
 1.05A 5x7rB-5w99A:
1.0		 5x7rB-5w99A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5w99 PBTD
(Planobispora
rosea) 		5 / 12 VAL A  62
LEU A 107
LEU A  18
ILE A  19
ALA A  21
 None
 1.32A 5xprA-5w99A:
undetectable		 5xprA-5w99A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5w99 PBTD
(Planobispora
rosea) 		3 / 3 TRP A 197
GLU A 198
GLU A 184
 None
 0.99A 6fhwA-5w99A:
undetectable		 6fhwA-5w99A:
22.08