SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wa0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  99
ALA A 250
PRO A 206
ASN A 209
LEU A 210
 None
 1.39A 1u70A-5wa0A:
undetectable		 1u70A-5wa0A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		6 / 11 SER A 290
VAL A 124
ALA A 344
PHE A 311
ILE A  68
PHE A  64
 None
 1.17A 1uduA-5wa0A:
undetectable		 1uduA-5wa0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		4 / 6 ALA A 111
ASP A  93
GLU A 112
ARG A 106
 None
 1.46A 2ouzA-5wa0A:
undetectable		 2ouzA-5wa0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		4 / 4 SER A 240
GLY A 241
HIS A 386
ASP A 137
 MSS  A 401 ( 4.6A)
MSS  A 401 (-3.9A)
None
None
 1.34A 2oxtC-5wa0A:
undetectable		 2oxtC-5wa0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		3 / 3 VAL A 124
ASN A 130
TRP A 150
 None
 0.72A 2y00B-5wa0A:
undetectable		 2y00B-5wa0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		4 / 8 HIS A 270
GLY A 381
ASN A 380
TYR A 384
 None
 1.20A 3ccfA-5wa0A:
undetectable		 3ccfA-5wa0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		5 / 11 VAL A 236
VAL A 200
ILE A 262
GLN A 263
THR A 258
 None
 1.29A 3elzB-5wa0A:
undetectable		 3elzB-5wa0A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 236
VAL A 200
ILE A 262
GLN A 263
THR A 258
 None
 1.32A 3elzC-5wa0A:
undetectable		 3elzC-5wa0A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		4 / 7 TYR A 384
ASN A 243
GLU A 257
GLN A 280
 None
 1.32A 3ugrA-5wa0A:
undetectable		 3ugrA-5wa0A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		4 / 8 ASN A 380
GLN A 280
LYS A 261
THR A 265
 None
 1.13A 4d1yA-5wa0A:
undetectable
4d1yB-5wa0A:
undetectable		 4d1yA-5wa0A:
20.60
4d1yB-5wa0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		4 / 4 LYS A 133
ARG A 132
GLY A 131
ASP A 137
 None
 1.42A 4ryaA-5wa0A:
undetectable		 4ryaA-5wa0A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		3 / 3 TYR A 267
TYR A  76
GLN A  78
 MSS  A 401 (-4.7A)
MSS  A 401 (-3.3A)
MSS  A 401 (-3.5A)
 0.74A 5jsdA-5wa0A:
undetectable
5jsdB-5wa0A:
undetectable		 5jsdA-5wa0A:
17.77
5jsdB-5wa0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5wa0 PUTATIVE SULFITE
OXIDASE
(Sinorhizobium
meliloti) 		3 / 3 TYR A 267
TYR A  76
GLN A  78
 MSS  A 401 (-4.7A)
MSS  A 401 (-3.3A)
MSS  A 401 (-3.5A)
 0.74A 5jsdB-5wa0A:
undetectable
5jsdC-5wa0A:
undetectable		 5jsdB-5wa0A:
17.77
5jsdC-5wa0A:
17.77