SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wa2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ6_B_CAMB502_0 (CYTOCHROME P450-CAM)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	4 / 5	PHE A 166 TYR A 149 VAL A 182 VAL A 198	None	1.41A	1dz6B-5wa2A: undetectable	1dz6B-5wa2A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PHG_A_MYTA422_1 (CYTOCHROME P450-CAM)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	5 / 11	LEU A 307 VAL A 308 GLY A 309 VAL A 210 ILE A 233	None	1.12A	1phgA-5wa2A: undetectable	1phgA-5wa2A: 11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A1O_B_CAMB2422_0 (CYTOCHROME P450-CAM)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	5 / 9	LEU A 307 VAL A 308 GLY A 309 VAL A 210 ILE A 233	None	1.12A	2a1oB-5wa2A: undetectable	2a1oB-5wa2A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_E_ZPCE1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	4 / 6	GLU A 79 TYR A 191 HIS A 189 PHE A 193	None	1.10A	4a97E-5wa2A: undetectable	4a97E-5wa2A: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H5F_A_SAMA301_1 (PROTEIN ARGININE N-METHYLTRANSFERASE SFM1)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	4 / 5	GLY A 143 PRO A 175 GLN A 240 THR A 138	None	1.17A	5h5fA-5wa2A: undetectable	5h5fA-5wa2A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IM2_A_BEZA401_0 (TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	5 / 12	VAL A 196 PRO A 169 LEU A 173 VAL A 198 PHE A 166	None	1.26A	5im2A-5wa2A: undetectable	5im2A-5wa2A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUD_A_ERMA2001_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	5 / 12	VAL A 194 VAL A 198 MET A 93 LEU A 137 VAL A 119	None	1.13A	5tudA-5wa2A: undetectable	5tudA-5wa2A: 11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCG_A_08YA602_2 (CYTOCHROME P450 3A4)	5wa2	SURFACE ANTIGEN (Toxoplasma gondii)	3 / 3	ARG A 134 ARG A 185 ARG A 132	None	0.90A	5vcgA-5wa2A: undetectable	5vcgA-5wa2A: 10.54

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DZ6_B_CAMB502_0","CYTOCHROME P450-CAM","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",4,"PHE A 166;TYR A 149;VAL A 182;VAL A 198","None","1.41A","1dz6B-5wa2A:undetectable","1dz6B-5wa2A:undetectable"],["1PHG_A_MYTA422_1","CYTOCHROME P450-CAM","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",5,"LEU A 307;VAL A 308;GLY A 309;VAL A 210;ILE A 233","None","1.12A","1phgA-5wa2A:undetectable","1phgA-5wa2A:11.78"],["2A1O_B_CAMB2422_0","CYTOCHROME P450-CAM","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",5,"LEU A 307;VAL A 308;GLY A 309;VAL A 210;ILE A 233","None","1.12A","2a1oB-5wa2A:undetectable","2a1oB-5wa2A:undetectable"],["4A97_E_ZPCE1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",4,"GLU A  79;TYR A 191;HIS A 189;PHE A 193","None","1.10A","4a97E-5wa2A:undetectable","4a97E-5wa2A:13.25"],["5H5F_A_SAMA301_1","PROTEIN ARGININE N-METHYLTRANSFERASE SFM1","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",4,"GLY A 143;PRO A 175;GLN A 240;THR A 138","None","1.17A","5h5fA-5wa2A:undetectable","5h5fA-5wa2A:undetectable"],["5IM2_A_BEZA401_0","TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",5,"VAL A 196;PRO A 169;LEU A 173;VAL A 198;PHE A 166","None","1.26A","5im2A-5wa2A:undetectable","5im2A-5wa2A:undetectable"],["5TUD_A_ERMA2001_1","5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",5,"VAL A 194;VAL A 198;MET A  93;LEU A 137;VAL A 119","None","1.13A","5tudA-5wa2A:undetectable","5tudA-5wa2A:11.03"],["5VCG_A_08YA602_2","CYTOCHROME P450 3A4","5wa2","SURFACE ANTIGEN","Toxoplasma gondii",3,"ARG A 134;ARG A 185;ARG A 132","None","0.90A","5vcgA-5wa2A:undetectable","5vcgA-5wa2A:10.54"]]