SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wa3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		5 / 12 LEU A 181
ILE A 225
ALA A 228
ALA A 231
LEU A 250
 None
 1.10A 1cbsA-5wa3A:
undetectable		 1cbsA-5wa3A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		5 / 11 PHE A 220
ALA A 342
ALA A 343
ALA A 173
LEU A 338
 None
 1.10A 2bxeB-5wa3A:
undetectable		 2bxeB-5wa3A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 4 LEU A 320
THR A 323
ILE A 315
HIS A 191
 None
 1.35A 2jfaB-5wa3A:
1.9		 2jfaB-5wa3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		5 / 9 PHE A 308
ALA A 307
TYR A 311
ALA A 184
GLY A 179
 None
 1.08A 2v7bA-5wa3A:
undetectable		 2v7bA-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		5 / 9 PHE A 308
ALA A 307
TYR A 311
ALA A 184
GLY A 179
 None
 1.10A 2v7bB-5wa3A:
undetectable		 2v7bB-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		5 / 12 PHE A 308
ALA A 343
LEU A 224
ALA A 228
GLY A 179
 None
 0.94A 2ve3A-5wa3A:
undetectable		 2ve3A-5wa3A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 7 TRP A 114
GLY A  17
ASP A  13
ARG A  11
 None
 1.16A 3arrA-5wa3A:
undetectable		 3arrA-5wa3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 5 GLY A 202
ASP A 201
ARG A 199
GLN A 331
 None
 1.32A 3qx3A-5wa3A:
undetectable		 3qx3A-5wa3A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		5 / 12 ALA A 343
SER A 229
TYR A 347
VAL A 183
ALA A 173
 None
 1.20A 3qxvE-5wa3A:
undetectable		 3qxvE-5wa3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		3 / 3 PHE A 333
CYH A 336
HIS A 191
 None
 0.93A 3u9fG-5wa3A:
undetectable		 3u9fG-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		3 / 3 PHE A 333
CYH A 336
HIS A 191
 None
 0.87A 3u9fS-5wa3A:
undetectable		 3u9fS-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 8 ARG A 100
TRP A  47
GLU A 103
GLU A 105
 None
 1.09A 4bqfB-5wa3A:
undetectable		 4bqfB-5wa3A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 8 SER A 233
SER A 229
LEU A 240
SER A 230
 None
 0.92A 4iklA-5wa3A:
undetectable
4iklB-5wa3A:
undetectable		 4iklA-5wa3A:
20.59
4iklB-5wa3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 5 ILE A 164
SER A 147
HIS A 321
ASP A  20
 None
 1.23A 4rzvB-5wa3A:
undetectable		 4rzvB-5wa3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 6 ALA A 342
VAL A 346
TYR A 347
VAL A 170
 None
 0.95A 5eckA-5wa3A:
2.6		 5eckA-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 6 ALA A 342
VAL A 346
TYR A 347
VAL A 227
 None
 0.81A 5eckA-5wa3A:
2.6		 5eckA-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 6 ALA A 342
VAL A 346
TYR A 347
VAL A 170
 None
 1.02A 5eckD-5wa3A:
2.5		 5eckD-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 6 ALA A 342
VAL A 346
TYR A 347
VAL A 227
 None
 0.81A 5eckD-5wa3A:
2.5		 5eckD-5wa3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wa3 PYRIDINE SYNTHASE
TBTD
(Thermobispora
bispora) 		4 / 6 ALA A 342
VAL A 346
TYR A 347
VAL A 227
 None
 0.90A 5eclA-5wa3A:
2.3		 5eclA-5wa3A:
undetectable